Postoperative Complications Associated with Laparoscopy-assisted Colectomy

Abstract: The intraoperative and postoperative complications of laparoscopic colectomy were analyzed in a consecutive series of 69 cases in our experience. The final histological diagnosis of these patients was adenoma of the colon in eight, carcinoma of the colon and rectum in 59, leiomyoma of the colon in one and Crohn's disease in one. The TIMM staging of the carcinomas in our series was Tis in four, T1 in 20, T2 in 10 and T3 in 25 cases. Conversion to open surgery was necessary in four of the 69 cases. The reasons for conversion were bleeding in two, adhesion in one and malignant invasion to the bladder in one. Major postoperative complications occurred in the four cases in whom a reoperation was carried out. These included perforation of the colon, pancreatic fistula, ileus and bleeding. Among the 11 minor postoperative complications, wound infection was the most frequent and occurred in six cases. There were no operative or postoperative deaths. The postoperative observation period ranged from one month to 4¹/₂ years. There was only one case with a possible local recurrence who had a CEA level of 34 ng/ml. In this patient, no findings of port site recurrence were detected. We thus consider laparoscopic-assisted colectomy, when done by technically well experienced surgeons, to be an effective and curative procedure for the treatment of colorectal carcinoma. However, in view of our complication rate, both sufficient training and experience with the techniques required to perform a laparoscopic colectomy are important for the future development of this procedure.     

Basaloid-squamous cell carcinoma of the oral mucosa: Report of two cases and study of the proliferative activity

Two cases of basalold-squamous cell carcinoma (BSC) of the oral mucosa are described. The first case occurred at the floor of the mouth in a 58-year-old man, and the second case occurred at the mandibular gingiva in a 79-year-old woman. The laboratory data of the first case showed a positive response to hepatitis C virus antibody. in the first case, the tumor mass measured 4 times 4 cm in size, and was i-texl at the lingual side of the median mandible beside the sublingual gland. In the second case, the tumor mass measured 25 times 15 mm In size, and was located in the alveolar mucosa of the right mandible. Histologically, both tumors showed a neoplastic epithelium arranged in a solid pattern with evidence of peripheral palisading, central necrosis, and some squamous differentiation. The pro-ilferathfe activities of the BSC were compared with conventional squamous cell carcinomas (SCC) in the oral floor and gingiva, respectively, by employing a sensitive argy-rophillc nuclear organizer region (AgNOR) staining method. The number of AgNOR per nucleus of the BSC was higher than that of any other SCC cases. The results support the opinion that BSC of the oral mucosa has a worse prognosis than conventional SCC.     

茶多酚自由基清除及抗脂蛋白氧化作用研究

目的:研究茶多酚体外清除氧自由基与抗脂蛋白氧化作用。方法:体解对ROO·、O2·-及OH·的清除作用采用化学发光法测定,H2O2的清除作用采用比色法测定。14名健康受试者空腹食用茶多酚后抽取静脉血,采用序列超速离心法分离血浆极低密度脂蛋白(VLDL)、低密度脂蛋白(LDL)和高密度脂蛋白(HDL),并观察各血浆脂蛋白过氧化程度以及氧化易感性的变化。结果:茶多酚对ROO·、O2·-、OH·及H2O2均有清除作用;食用茶多酚后受试者VLDL、LDL和HDL过氧化脂质(LPO)水平明显降低;在体外进行氧化修饰时,LDL氧化延滞时间明显延长,提示LDL氧化易感性下降。结论:茶多酚可增强血浆抗氧化能力,因此能够起到预防心血管疾病和延缓衰老的积极作用。