Texture segregation with luminance and chromatic contrast

Preattentive texture discrimination was investigated using low spatial frequency texture elements. The contrast between the texture elements and the background was either purely luminance or purely chromatic, or some combination of both these types of contrast. The threshold to discriminate correctly the location of a different textured region was obtained from each subject, as was each subject's threshold to detect the elements of the texture. Using the ratio of texture to element detection as a measure of the effectiveness of texture discrimination, little difference could be found between the perception of luminance or chromatic texture. However, there were large and significant variations among subjects with otherwise normal colour vision.     

Comparative visual performance of three presbyopic contact lens corrections.

We compared the visual performance of a soft diffractive (DIFF) bifocal contact lens, a near center (CN) concentric bifocal design, and monovision (MV), using a comprehensive vision testing protocol. Fifteen presbyopic subjects who were successfully wearing DIFF bifocal contact lenses participated in the study. Of the three systems tested, MV provided best visual acuity at distance and near; less than one line of acuity was lost relative to best spectacle acuity under all lighting and contrast conditions, and there was less disturbance of a point source of light. Both bifocal corrections gave similar visual acuity performance, with more lines of acuity lost relative to spectacles at near compared to distance. However, the concentric bifocal induced more ghosting at near than the other two systems. Stereopsis was compromised at distance with MV correction, but all systems performed worse than spectacles at near. An understanding of the strengths and weaknesses of presbyopic contact lens options allows the clinician to improve management of the presbyope who wishes to wear contact lenses.     

Cross tolerance or tachyphylaxis among various psychotomimetic agents on cats

DOM, 2,5-dimethoxy-4-methylamphetamine, a perception-distorting psychotomimetic agent, has been demonstrated to elicit a marked behavioral syndrome in cats. This syndrome is antagonized by a pretreatment of DOM. This tachyphylaxis has been examined to determine the ability of various other types of psychotomimetic agents to antagonize the DOM-induced syndrome. Mescaline and d-LSD but not 1-LSD could prevent the occurrence of the DOM-induced behavior. Ditran, tryptamine and d-amphetamine did not antagonize DOM. Thus it appears that the perception-distorting psychotomimetic agents exhibit either cross tachyphylaxis or cross tolerance and may share a common mechanism of action.     

Pheochromocytoma and the normal adrenal medulla: improved visualization with I-123 MIBG scintigraphy

The radiopharmaceutical iodine 131 metaiodobenzylguanidine (I-131 MIBG) has been shown to locate pheochromocytomas scintigraphically with a false-negative rate of approximately 13%. To improve image quality and reduce the false-negative rate, I-123 was examined as a radioactive label for MIBG, as it has many advantages over I-131, including superior dosimetry and better detection efficiency. Diagnostic doses of 0.5 mCi (18.5 MBq) I-131 MIBG and 10.0 mCi (370.0 MBq) I-123 MIBG with nearly equivalent radiation dosimetries were compared in 18 patients with known or suspected pheochromocytomas. Images of superior quality were obtained with I-123 MIBG in 18 of 18 patients, and in eight cases lesions not visualized on I-131 MIBG scintigraphy were portrayed. A further advantage of I-123 MIBG is that it permits single photon emission computed tomography (SPECT). This was performed in six cases and provided additional information in three cases. The adrenal medullae were definitely visualized using I-123 scintigraphy in eight of 14 patients still possessing adrenal glands, whereas I-131 MIBG images portrayed the adrenal medulla in only one of 14 cases. Five remaining patients had multiple abdominal tumor deposits that were difficult to differentiate from normal adrenal medullae.