全文获取类型
收费全文 | 593篇 |
免费 | 17篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 24篇 |
妇产科学 | 18篇 |
基础医学 | 76篇 |
口腔科学 | 15篇 |
临床医学 | 25篇 |
内科学 | 106篇 |
皮肤病学 | 3篇 |
神经病学 | 83篇 |
特种医学 | 14篇 |
外科学 | 65篇 |
预防医学 | 85篇 |
眼科学 | 7篇 |
药学 | 59篇 |
肿瘤学 | 39篇 |
出版年
2023年 | 3篇 |
2022年 | 8篇 |
2021年 | 14篇 |
2020年 | 12篇 |
2019年 | 7篇 |
2018年 | 7篇 |
2017年 | 6篇 |
2016年 | 7篇 |
2015年 | 9篇 |
2014年 | 13篇 |
2013年 | 19篇 |
2012年 | 32篇 |
2011年 | 43篇 |
2010年 | 27篇 |
2009年 | 19篇 |
2008年 | 40篇 |
2007年 | 49篇 |
2006年 | 40篇 |
2005年 | 42篇 |
2004年 | 44篇 |
2003年 | 30篇 |
2002年 | 32篇 |
2001年 | 6篇 |
2000年 | 15篇 |
1999年 | 7篇 |
1998年 | 6篇 |
1997年 | 6篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1992年 | 5篇 |
1991年 | 7篇 |
1990年 | 4篇 |
1989年 | 4篇 |
1988年 | 3篇 |
1987年 | 6篇 |
1986年 | 4篇 |
1985年 | 12篇 |
1984年 | 2篇 |
1981年 | 2篇 |
1978年 | 1篇 |
1977年 | 4篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1968年 | 1篇 |
1967年 | 4篇 |
1966年 | 2篇 |
1961年 | 1篇 |
排序方式: 共有620条查询结果,搜索用时 9 毫秒
11.
Edina A. Wappler Péter Antal Szabolcs Várbíró Béla Székács Andrea Simon Zoltán Nagy Emil Monos György L. Nádasy 《Mechanisms of ageing and development》2013,134(7-8):307-313
AimsTo identify the geometrical alterations in the age-remodeled rat coronary artery network and to develop a useful technique to analyze network properties in the rat heart.Methods and resultsWe analyzed the networks of the left anterior descendent coronary arteries on in situ perfused hearts of young (3 months) and old (18 months) male rats. All segments and branching over >80 μm diameter were analyzed using 50 μm long cylindrical ring units of the networks. Arterial widening and paucity, increased tortuosity were typical features in the old network. In addition, axis angles deviated more from the mother branches in the old, whereas the diameters of daughter branches fit the Murray law in both groups. The detected changes in the old network resulted in a longer blood flow route for the same direct distance.ConclusionWe developed a useful method to investigate arterial network property changes in the rat heart. Ageing resulted in longer, more tortuous flow route in the LAD network that might be hemodynamically disadvantageous. 相似文献
12.
13.
Jamese J. Hilliard Vivekananda Datta Christine Tkaczyk Melissa Hamilton Agnieszka Sadowska Omari Jones-Nelson Terrence O'Day William J. Weiss Szabolcs Szarka Vien Nguyen Laszlo Prokai JoAnn Suzich C. Kendall Stover Bret R. Sellman 《Antimicrobial agents and chemotherapy》2015,59(1):299-309
Alpha-toxin (AT) is a major virulence determinant in Staphylococcus aureus skin and soft tissue infection models. We previously demonstrated that prophylactic administration of 2A3, an AT-neutralizing monoclonal antibody (MAb), prevents S. aureus disease in a mouse dermonecrosis model by neutralizing AT-mediated tissue necrosis and immune evasion. In the present study, MEDI4893*, an affinity-optimized version of 2A3, was characterized for therapeutic activity in the dermonecrosis model as a single agent and in combination with two frontline antibiotics, vancomycin and linezolid. MEDI4893* postinfection therapy was found to exhibit a therapeutic treatment window similar to that for linezolid but longer than that for vancomycin. Additionally, when combined with either vancomycin or linezolid, MEDI4893* resulted in reduced tissue damage, increased neutrophil and macrophage infiltration and abscess formation, and accelerated healing relative to those with the antibiotic monotherapies. These data suggest that AT neutralization with a potent MAb holds promise for both prophylaxis and adjunctive therapy with antibiotics and may be a valuable addition to currently available options for the treatment of S. aureus skin and soft tissue infections. 相似文献
14.
15.
16.
17.
18.
Szabolcs Kéri Helga Nagy Einat Levy‐Gigi Oguz Kelemen 《The European journal of neuroscience》2013,38(11):3650-3658
There is widespread evidence that dopamine is implicated in the regulation of reward and salience. However, it is less known how these processes interact with attention and recognition memory. To explore this question, we used the attentional boost test in patients with Parkinson's disease (PD) before and after the administration of dopaminergic medications. Participants performed a visual letter detection task (remembering rewarded target letters and ignoring distractor letters) while also viewing a series of photos of natural and urban scenes in the background of the letters. The aim of the game was to retrieve the target letter after each trial and to win as much virtual money as possible. The recognition of background scenes was not rewarded. We enrolled 26 drug‐naïve, newly diagnosed patients with PD and 25 healthy controls who were evaluated at baseline and follow‐up. Patients with PD received dopamine agonists (pramipexole, ropinirole, rotigotine) during the 12‐week follow‐up period. At baseline, we found intact attentional boost in patients with PD: they were able to recognize target‐associated scenes similarly to controls. At follow‐up, patients with PD outperformed controls for both target‐ and distractor‐associated scenes, but not when scenes were presented without letters. The alerting, orienting and executive components of attention were intact in PD. Enhanced attentional boost was replicated in a smaller group of patients with PD (n = 15) receiving l ‐3,4‐dihydroxyphenylalanine (L‐DOPA). These results suggest that dopaminergic medications facilitate attentional boost for background information regardless of whether the central task (letter detection) is rewarded or not. 相似文献
19.
Tamas Papp Angela Polyak Krisztina Papp Zoltan Meszar Roza Zakany Eva Meszar-Katona Palne Terdik Tünde Chang Hwa Ham Szabolcs Felszeghy 《International journal of oral science》2016,8(1):24-31
Although several heat shock proteins have been investigated in relation to tooth development, no available information is available about the spatial and temporal expression pattern of heat shock protein 60 (Hsp 60). To characterize Hsp 60 expression in the structures of the developing tooth germ, we used Western blotting, immunohistochemistry and in situ hybridization. Hsp 60 was present in high amounts in the inner and outer enamel epithelia, enamel knot (EK) and stratum intermedium (SI). Hsp 60 also appeared in odontoblasts beginning in the bell stage. To obtain data on the possible effect of Hsp 60 on isolated lower incisors from mice, we performed in vitro culturing. To investigate the effect of exogenous Hsp 60 on the cell cycle during culturing, we used the 5-bromo-2- deoxyuridine (BrdU) incorporation test on dental cells. Exogenously administered Hsp 60 caused bluntness at the apical part of the 16.5-day-old tooth germs, but it did not influence the proliferation rate of dental cells. We identified the expression of Hsp 60 in the developing tooth germ, which was present in high concentrations in the inner and outer enamel epithelia, EK, SI and odontoblasts. High concentration of exogenous Hsp 60 can cause abnormal morphology of the tooth germ, but it did not influence the proliferation rate of the dental cells. Our results suggest that increased levels of Hsp 60 may cause abnormalities in the morphological development of the tooth germ and support the data on the significance of Hsp during the developmental processes. 相似文献
20.
Dunckley T Huentelman MJ Craig DW Pearson JV Szelinger S Joshipura K Halperin RF Stamper C Jensen KR Letizia D Hesterlee SE Pestronk A Levine T Bertorini T Graves MC Mozaffar T Jackson CE Bosch P McVey A Dick A Barohn R Lomen-Hoerth C Rosenfeld J O'connor DT Zhang K Crook R Ryberg H Hutton M Katz J Simpson EP Mitsumoto H Bowser R Miller RG Appel SH Stephan DA 《The New England journal of medicine》2007,357(8):775-788