全文获取类型
收费全文 | 157762篇 |
免费 | 32852篇 |
国内免费 | 2459篇 |
专业分类
耳鼻咽喉 | 5200篇 |
儿科学 | 5594篇 |
妇产科学 | 2449篇 |
基础医学 | 4171篇 |
口腔科学 | 1665篇 |
临床医学 | 27106篇 |
内科学 | 49360篇 |
皮肤病学 | 7524篇 |
神经病学 | 15406篇 |
特种医学 | 6716篇 |
外国民族医学 | 1篇 |
外科学 | 42508篇 |
综合类 | 258篇 |
现状与发展 | 72篇 |
预防医学 | 7132篇 |
眼科学 | 3511篇 |
药学 | 1575篇 |
中国医学 | 36篇 |
肿瘤学 | 12789篇 |
出版年
2024年 | 516篇 |
2023年 | 4815篇 |
2022年 | 1260篇 |
2021年 | 3221篇 |
2020年 | 6099篇 |
2019年 | 2255篇 |
2018年 | 7484篇 |
2017年 | 7432篇 |
2016年 | 8564篇 |
2015年 | 8575篇 |
2014年 | 15673篇 |
2013年 | 15827篇 |
2012年 | 5830篇 |
2011年 | 5888篇 |
2010年 | 10581篇 |
2009年 | 14457篇 |
2008年 | 6178篇 |
2007年 | 4505篇 |
2006年 | 6876篇 |
2005年 | 4236篇 |
2004年 | 3498篇 |
2003年 | 2509篇 |
2002年 | 2526篇 |
2001年 | 3976篇 |
2000年 | 3167篇 |
1999年 | 3396篇 |
1998年 | 3797篇 |
1997年 | 3589篇 |
1996年 | 3502篇 |
1995年 | 3334篇 |
1994年 | 2043篇 |
1993年 | 1666篇 |
1992年 | 1507篇 |
1991年 | 1561篇 |
1990年 | 1194篇 |
1989年 | 1309篇 |
1988年 | 1135篇 |
1987年 | 959篇 |
1986年 | 989篇 |
1985年 | 812篇 |
1984年 | 629篇 |
1983年 | 588篇 |
1982年 | 562篇 |
1981年 | 449篇 |
1980年 | 407篇 |
1979年 | 355篇 |
1978年 | 375篇 |
1977年 | 443篇 |
1975年 | 317篇 |
1972年 | 330篇 |
排序方式: 共有10000条查询结果,搜索用时 203 毫秒
11.
12.
13.
Two Janus-associated kinase inhibitors (JAKi) (initially ruxolitinib and, more recently, fedratinib) have been approved as treatment options for patients who have intermediate-risk and high-risk myelofibrosis (MF), with pivotal trials demonstrating improvements in spleen volume, disease symptoms, and quality of life. At the same time, however, clinical trial experiences with JAKi agents in MF have demonstrated a high frequency of discontinuations because of adverse events or progressive disease. In addition, overall survival benefits and clinical and molecular predictors of response have not been established in this population, for which the disease burden is high and treatment options are limited. Consistently poor outcomes have been documented after JAKi discontinuation, with survival durations after ruxolitinib ranging from 11 to 16 months across several studies. To address such a high unmet therapeutic need, various non-JAKi agents are being actively explored (in combination with ruxolitinib in first-line or salvage settings and/or as monotherapy in JAKi-pretreated patients) in phase 3 clinical trials, including pelabresib (a bromodomain and extraterminal domain inhibitor), navitoclax (a B-cell lymphoma 2/B-cell lymphoma 2-xL inhibitor), parsaclisib (a phosphoinositide 3-kinase inhibitor), navtemadlin (formerly KRT-232; a murine double-minute chromosome 2 inhibitor), and imetelstat (a telomerase inhibitor). The breadth of data expected from these trials will provide insight into the ability of non-JAKi treatments to modify the natural history of MF. 相似文献
14.
Raymond J. Chan RN PhD Vivienne E. Milch MBBS MHPol Fiona Crawford-Williams PhD Oluwaseyifunmi Andi Agbejule BRadTherapy Ria Joseph MNutrDiet Jolyn Johal BND Narayanee Dick BSc Matthew P. Wallen PhD Julie Ratcliffe PhD Anupriya Agarwal MBBS Larissa Nekhlyudov MD Matthew Tieu PhD Manaf Al-Momani BPharm Scott Turnbull PhD Rahul Sathiaraj MPH Dorothy Keefe MBBS MD Nicolas H. Hart PhD 《CA: a cancer journal for clinicians》2023,73(6):565-589
Patient navigation is a strategy for overcoming barriers to reduce disparities and to improve access and outcomes. The aim of this umbrella review was to identify, critically appraise, synthesize, and present the best available evidence to inform policy and planning regarding patient navigation across the cancer continuum. Systematic reviews examining navigation in cancer care were identified in the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, Cumulative Index of Nursing and Allied Health (CINAHL), Epistemonikos, and Prospective Register of Systematic Reviews (PROSPERO) databases and in the gray literature from January 1, 2012, to April 19, 2022. Data were screened, extracted, and appraised independently by two authors. The JBI Critical Appraisal Checklist for Systematic Review and Research Syntheses was used for quality appraisal. Emerging literature up to May 25, 2022, was also explored to capture primary research published beyond the coverage of included systematic reviews. Of the 2062 unique records identified, 61 systematic reviews were included. Fifty-four reviews were quantitative or mixed-methods reviews, reporting on the effectiveness of cancer patient navigation, including 12 reviews reporting costs or cost-effectiveness outcomes. Seven qualitative reviews explored navigation needs, barriers, and experiences. In addition, 53 primary studies published since 2021 were included. Patient navigation is effective in improving participation in cancer screening and reducing the time from screening to diagnosis and from diagnosis to treatment initiation. Emerging evidence suggests that patient navigation improves quality of life and patient satisfaction with care in the survivorship phase and reduces hospital readmission in the active treatment and survivorship care phases. Palliative care data were extremely limited. Economic evaluations from the United States suggest the potential cost-effectiveness of navigation in screening programs. 相似文献
15.
16.
17.
18.
Susumu Shibasaki Koichi Suda Masaya Nakauchi Kenichi Nakamura Kenji Kikuchi Kazuki Inaba Ichiro Uyama 《World journal of gastroenterology : WJG》2020,26(11):1172-1184
BACKGROUND Minimally invasive surgery for gastric cancer(GC) has gained widespread use as a safe curative procedure especially for early GC.AIM To determine risk factors for postoperative complications after minimally invasive gastrectomy for GC.METHODS Between January 2009 and June 2019, 1716 consecutive patients were referred to our division for primary GC. Among them, 1401 patients who were diagnosed with both clinical and pathological Stage Ⅲ or lower GC and underwent robotic gastrectomy(RG) or laparoscopic gastrectomy(LG) were enrolled. Retrospective chart review and multivariate analysis were performed for identifying risk factors for postoperative morbidity.RESULTS Morbidity following minimally invasive gastrectomy was observed in 7.5% of the patients. Multivariate analyses demonstrated that non-robotic minimally invasive surgery, male gender, and an operative time of ≥ 360 min were significant independent risk factors for morbidity. Therefore, morbidity was compared between RG and LG. Accordingly, propensity-matched cohort analysis revealed that the RG group had significantly fewer intra-abdominal infectious complications than the LG group(2.5% vs 5.9%, respectively; P = 0.038), while no significant differences were noted for other local or systemic complications.Multivariate analyses of the propensity-matched cohort revealed that non-robotic minimally invasive surgery [odds ratio = 2.463(1.070–5.682); P = 0.034] was a significant independent risk factor for intra-abdominal infectious complications.CONCLUSION The findings showed that robotic surgery might improve short-term outcomes following minimally invasive radical gastrectomy by reducing intra-abdominal infectious complications. 相似文献
19.
20.