全文获取类型
收费全文 | 4641篇 |
免费 | 338篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 148篇 |
妇产科学 | 108篇 |
基础医学 | 713篇 |
口腔科学 | 128篇 |
临床医学 | 359篇 |
内科学 | 1115篇 |
皮肤病学 | 216篇 |
神经病学 | 534篇 |
特种医学 | 44篇 |
外科学 | 324篇 |
综合类 | 21篇 |
预防医学 | 396篇 |
眼科学 | 144篇 |
药学 | 370篇 |
中国医学 | 33篇 |
肿瘤学 | 327篇 |
出版年
2023年 | 35篇 |
2022年 | 52篇 |
2021年 | 169篇 |
2020年 | 101篇 |
2019年 | 163篇 |
2018年 | 178篇 |
2017年 | 127篇 |
2016年 | 147篇 |
2015年 | 156篇 |
2014年 | 216篇 |
2013年 | 253篇 |
2012年 | 439篇 |
2011年 | 422篇 |
2010年 | 239篇 |
2009年 | 189篇 |
2008年 | 341篇 |
2007年 | 288篇 |
2006年 | 271篇 |
2005年 | 285篇 |
2004年 | 255篇 |
2003年 | 222篇 |
2002年 | 230篇 |
2001年 | 12篇 |
2000年 | 9篇 |
1999年 | 30篇 |
1998年 | 29篇 |
1997年 | 24篇 |
1996年 | 21篇 |
1995年 | 13篇 |
1994年 | 8篇 |
1993年 | 12篇 |
1992年 | 9篇 |
1991年 | 7篇 |
1990年 | 4篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 6篇 |
1986年 | 6篇 |
1983年 | 2篇 |
1982年 | 5篇 |
1981年 | 4篇 |
1980年 | 2篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1974年 | 2篇 |
1973年 | 1篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有4999条查询结果,搜索用时 15 毫秒
81.
82.
Pino Cidad Ana Boto Almudena Del Hierro Maria Capote Susana Noval Amanda Garcia Susana Santiago 《Korean journal of ophthalmology : KJO》2014,28(3):278-283
We studied three patients who developed left unilateral punctate keratitis after suffering left-sided Wallenberg Syndrome. A complex evolution occurred in two of them. In all cases, neurophysiological studies showed damage in the trigeminal sensory component at the bulbar level. Corneal involvement secondary to Wallenberg syndrome is a rare cause of unilateral superficial punctate keratitis. The loss of corneal sensitivity caused by trigeminal neuropathy leads to epithelial erosions that are frequently unobserved by the patient, resulting in a high risk of corneal-ulcer development with the possibility of superinfection. Neurophysiological studies can help to locate the anatomical level of damage at the ophthalmic branch of the trigeminal nerve, confirming the suspected etiology of stroke, and demonstrating that prior vascular involvement coincides with the location of trigeminal nerve damage. In some of these patients, oculofacial pain is a distinctive feature. 相似文献
83.
84.
85.
Sandra Leal Lídia Rocha Ana Silva Juliana Faria Ricardo Jorge Dinis-Oliveira Susana I. Sá 《Pathology, research and practice》2018,214(12):2115-2120
Tamoxifen (TAM) therapy is the better treatment for breast cancer and the drug use the prophylaxis of this disease in young premenopausal women. Yet, the effects associated with this therapy are unknown. To better understand the extension of this problem, we developed an animal model to mimic this therapy, aiming to evaluate its potential biochemical and histopathological changes in the liver. Young cycling female rats were treated with TAM for one, two and three months and toxicological biomarkers and liver histomorphometry were evaluated. Starting at two months, TAM-treatment prevented the normal age-dependent increase in body weight, without inducing changes in food intake. Serum levels of cholesterol and of the metabolic enzymes creatine kinase and aspartate aminotransferase were reduced in all TAM treatment periods. Serum levels of the metabolic enzymes alkaline phosphatase and lactate dehydrogenase were increased after the first month but returned to control levels upon 3 months of drug exposition. Moderate microvesicular steatosis, classified only at the first month of TAM treatment, was reduced afterwards. Our model showed an adaptive response of liver upon 3 months of treatment, suggesting that at the stated conditions, TAM will not promote hepatotoxicity. In this way, the present model may be useful in the study of possible key endocrine effects of TAM use and the search for better clinical outcomes. 相似文献
86.
87.
José Saura Llamas María Nieves Martínez Garre María Elena Sebastián Delgado María Ángeles Martínez Navarro Mariano Leal Hernández Susana Blanco Sabio Antonio Martínez Pastor 《Atencion primaria / Sociedad Espa?ola de Medicina de Familia y Comunitaria》2013,45(6):297-306
ObjectiveTo evaluate the performance and quality of the 10 groups of training tasks envisaged in the portfolio training model undertaken by all residents of the Primary Care Teaching Unit in Murcia.DesignA cross-sectional study was conducted on the portfolios provided and completed by all residents in May 2011.ParticipantsAll residents who were in training at that time (131).MethodTen groups of training tasks were established from those recommended by the National Commission for the specialty. The performance of each one in each of the portfolios was evaluated, and the compliance for each training task was calculated. The quality of the performance of each of the tasks was given a score, 0 points (very poor) to 10 points (excellent).ResultsAs regards compliance, the tasks that were most performed were: filling in the Resident book correctly and using the resident skills guide, both with 99.24%, followed by reflection reports on the training visits. All tasks had a compliance rate higher than 67%. The mean percentage of compliance was 86.49%. All tasks obtained an average score greater than 7 (outstanding). The overall mean score was 7,8 points.ConclusionsThe level of perfomance of the tasks set out in the portfolio by the residents was very satisfying. It is necessary to continue working on improving the performance of the portfolio. 相似文献
88.
Lars Penke Maria C. Valdés Hernandéz Susana Muñoz Maniega Alan J. Gow Catherine MurrayJohn M. Starr Mark E. Bastin Ian J. Deary Joanna M. Wardlaw 《Neurobiology of aging》2012,33(3):510-517
A novel analysis of magnetic resonance imaging (MRI) scans based on multispectral image fusion was used to quantify iron deposits in basal ganglia and microbleeds in 143 nondemented subjects of the generally healthy Lothian Birth Cohort, who were tested for general cognitive ability (intelligence) at mean ages of 11, 70, and 72 years. Possessing more iron deposits at age 72 was significantly associated with lower general cognitive ability at age 11, 70, and 72, explaining 4% to 9% of the variance. The relationships with old age general cognitive ability remained significant after controlling for childhood cognition, suggesting that iron deposits are related to lifetime cognitive decline. Most iron deposits were in the basal ganglia, with few microbleeds. While iron deposits in the general population have so far been dismissed in the literature, our results show substantial associations with cognitive functioning. The pattern of results suggests that iron deposits are not only a biomarker of general cognitive ability in old age and age-related cognitive decline, but that they are also related to the lifelong-stable trait of intelligence. 相似文献
89.
José Mesquita Bastos MD Susana Bertoquini PsychD Jorge Polónia MD PhD 《Journal of clinical hypertension (Greenwich, Conn.)》2010,12(7):508-515
J Clin Hypertens(Greenwich). 2010;12:508–515. © 2010 Wiley Periodicals, Inc. To evaluate the long-term prognostic significance of different ranges of the percentage fall in nighttime blood pressure (BP) of the nondipping pattern, 1200 hypertensive patients (645 women, age 51±12 years) underwent ambulatory BP monitoring under stabilized therapy. The occurrence of cardiovascular (CV) events was followed for 9833 patient-years and analyzed by the Cox hazard model. There were 152 CV fatal/nonfatal events (79 strokes, 51 coronary events, 22 others) during the 15.2 years of follow-up. According to nighttime BP fall (%) the authors noted: <0% (reverse-dippers [RD], n=83); 0%–4.9% (nondippers 1 [ND1], n=207); 5%–9.9% (nondippers 2 [ND2], n=311), 10%–19.9% (dippers [D], n=523); and ≥20% (extreme dippers [ED], n=76). After adjustment for confounding variables, hazard ratios (95% confidence interval) of CV event and stroke in RD vs D were 2.29 (1.31–3.99) and 2.46 (1.11–5.49); of ND1 vs D were 1.42 (1.12–1.79) and 1.62 (1.17–2.23); and of ND1 vs ND2 were 2.24 (1.33–3.75) and 2.30 (1.15–4.58). No differences were found in RD vs ND1 and ND2 vs D. Nondippers have a higher CV risk than dippers but only for a nighttime BP fall <5% suggesting that the limits for nondipping should be redefined for a stratification of CV risk. 相似文献
90.