How does accelerometry-measured arm elevation at work influence prospective risk of long-term sickness absence?

ObjectiveElevated arm work is prevalent in many jobs. Feasible device-based methods are available to measure elevated arm work. However, we lack knowledge on the association between device-measured elevated arm work and prospective risk of long-term sickness absence (LTSA). We aimed to investigate this association.MethodsAt baseline, 937 workers wore accelerometers on the right arm and thigh over 1–5 workdays to measure work time spent with elevated arms in an upright position. Between baseline and 4-year prospective follow-up in the national registers, we obtained information on the individuals’ first event of LTSA (≥6 consecutive weeks). We performed compositional Cox proportional hazard analyses to model the association between work time with arm elevation >30°, >60°, or >90° and the probability of LTSA.ResultsWorkers spent 21% of their work time with >30° arm elevation, 4% with >60° arm elevation, and 1% with >90° arm elevation; in the upright body position. We found a positive dose–response association between work time spent with elevated arm work and the risk of LTSA. Specifically, we found that increasing two minutes of work time spent with arm elevation at (i) >90° increased the risk of LTSA by 14% [hazard ratio (HR) 1.14, 95% confidence intervals (95% CI 1.04–1.25)] (ii) >60° increased the LTSA risk by 3% (HR 1.03, 95% CI 1.03–1.06), and (iii) >30° increased the LTSA risk by 1% (HR 1.01, 95% CI 1.00–1.02).ConclusionDevice-measured elevated arm work is associated with increased prospective LTSA. This information ought to be brought into preventive workplace practice by accessible and feasible device-based methods of elevated arm work.     

子宫内膜异位症患者血清细胞因子水平的测定

子宫内膜异位症患者血清细胞因子水平的测定程凯灵令狐华子宫内膜异位症（ＥＭＳ）是妇科常见病。国内外学者的研究表明，免疫学的变化在该病的病理生理学中有重要意义。本研究通过酶联免疫吸附试验（ＥＬＩＳＡ），对ＥＭＳ患者血清细胞因子［白细胞介素（ＩＬ）－６、Ｉ...     

江苏省经济较发达地区老年福利机构收住老年人35年动态调查

为今后制定我国老年社会福利工作规划提供信息，对江苏省经济较发达地区老年福利机构的现状及35年来收住老人的动态变化作回顾性调查．结果显示，自我国改革开放以来老年社会福利事业得到较快的发展，80年代后老人人院数大幅度增加，人院老人中70岁以上老人占77．3％，女性多于男性，单身老人多于双居老人，较高文化层次的老人逐年增加，因子女照顾困难而人院者占人院总数的60．2％。     

社区与住院精神病人的精神残疾调查

本文用社会功能缺陷筛选表对890名社区精神病人，用住院精神病人社会功能评定量表对203名长期住院的慢性精神病人进行了评定，划分出各自的精神残疾等级并进行对照分析。结果表明，住院与社区病人的残疾等级分布一致，极重度（一级）与轻度（四级）所占比例较高，并反映残疾等级与疾病的种类、病程、家庭照顾、治疗及劳动能力等因素有关。住院病人在性别、婚姻等方面与社区病人有差异。     

瘦素与肝纤维化

瘦素最初被认为是一种由脂肪细胞分泌的蛋白,能抑制食欲,增加耗能。近年来研究发现肝星状细胞也能分泌瘦素,而且肝星状细胞、窦内皮细胞、枯否细胞等肝脏间质细胞均有瘦素受体表达,瘦素通过受体发挥其生物学效应。窦内皮细胞和枯否细胞是瘦素促进肝纤维化的靶细胞,再进一步活化肝星状细胞,而肝星状细胞的活化是肝纤维化发生发展的中心环节,因此瘦素与肝问质细胞的关系成为肝纤维化研究的热点,本文就这方面作一综述。     

行为方式与青中年脑梗塞的关系

目的：探讨行为方式与青中年脑梗塞的相关性。方法：选择５０例青中年脑梗塞患者与性别、年龄、职业、文化背景、经济状况相近似的３５例非脑血管病患者作对照，两组均回答Ａ型行为类型问卷及自制生活习性问卷。结果：在Ａ型行为、中、重度吸烟及饮酒、频繁在外就餐等习性，肥胖及舒张压偏高、血脂测定等诸方面两组差异有显著性（Ｐ＜０．０５）。结论：调整行为方式及饮食结构是预防青中年缺血性脑血管病的重要举措     

注意缺损多动障碍与5-HT_(2a)受体基因多态性的相关分析

目的：探讨注意缺损多动障碍（ＡＤＨＤ）与５－ＨＴ２ａ受体基因多态性之间的相互关系。方法：应用聚合酶链式反应（ＰＣＲ）和限制性片段长度多态性（ＲＦＬＰ）方法。在７４例ＡＤＨＤ儿童及其父母和８１例正常成人中观察５－ＨＴ２ａ受体基因多态性的分布。采用单体型相对风险分析方法研究ＡＤＨＤ与５－ＨＴ２ａ受体基因间的遗传关联。结果：经基于基因型的单体型相对风险（ＧＨＲＲ）和基于单体型的单体型相对风险（ＨＨＲＲ）分析表明，ＡＤＨＤ与５－ＨＴ２ａ受体基因各等位基因及基因型之间并不存在关联（Ｐ＞０．０５）。结论：ＡＤＨＤ与５－ＨＴ２ａ受体基因多态性之间无关联     

RP-HPLC法检测大鼠血浆大黄酸含量的经时变化

目的：观察大鼠口服清热解毒方后,其有效成分大黄酸在大鼠血浆中的经时变化规律。方法：采用RP-HPLC法,色谱柱Kromasil C18（250mm×4.6mm,5μm）,以甲醇-0.1%磷酸（85∶15）为流动相,流速1.0mL/min,检测波长254nm,柱温35℃。结果：大鼠口服清热解毒方后,血浆中大黄酸1h达峰值,之后缓慢下降,于12h内基本代谢完全。结论：采用反相高效液相色谱法检测大鼠体内药物含量简便、快捷,适合于研究中药类成分的代谢特征。