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101.
ChandraMohan Ramasamy Biswajit Dubashi J. Sree Rekha Debdatta Basu Ankit Jain Tarun Kumar Dutta 《Indian journal of hematology & blood transfusion》2014,30(1):59-61
We report a case of hairy cell leukemia who improved after cladribine but succumbed to disseminated atypical mycobacterial infection 2 months after completing cladribine. 相似文献
102.
Gabriel Courties Timo Heidt Matthew Sebas Yoshiko Iwamoto Derrick Jeon Jessica Truelove Benoit Tricot Greg Wojtkiewicz Partha Dutta Hendrik B. Sager Anna Borodovsky Tatiana Novobrantseva Boris Klebanov Kevin Fitzgerald Daniel G. Anderson Peter Libby Filip K. Swirski Ralph Weissleder Matthias Nahrendorf 《Journal of the American College of Cardiology》2014
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Danda Sumita Mohan Sony Devaraj Prabavathi Dutta Atanu K. Nampoothiri Sheela Yesodharan Dhanya Phadke Shubha R. Jalan Anil B. Thangaraj K. Verma Ishwar Chandra Danda Debashish Jebaraj Isaac 《Clinical rheumatology》2020,39(9):2743-2749
Clinical Rheumatology - Alkaptonuria (AKU) is a rare metabolic disease. The global incidence is 1:100,000 to 1:250,000. However, identification of a founder mutation in a gypsy population from... 相似文献
105.
Robert A. Allen Wei Wu Mingyi Yao Debaditya Dutta Xinjie Duan Timothy N. Bachman Hunter C. Champion Donna B. Stolz Anne M. Robertson Kang Kim Jeffrey S. Isenberg Yadong Wang 《Biomaterials》2014
The objective of this study was to evaluate the long-term performance of cell-free vascular grafts made from a fast-degrading elastic polymer. We fabricated small arterial grafts from microporous tubes of poly(glycerol sebacate) (PGS) reinforced with polycaprolactone (PCL) nanofibers on the outer surface. Grafts were interpositioned in rat abdominal aortas and characterized at 1 year post-implant. Grafts remodeled into “neoarteries” (regenerated arteries) with similar gross appearance to native rat aortas. Neoarteries mimic arterial tissue architecture with a confluent endothelium and media and adventita-like layers. Patent vessels (80%) showed no significant stenosis, dilation, or calcification. Neoarteries contain nerves and have the same amount of mature elastin as native arteries. Despite some differences in matrix organization, regenerated arteries had similar dynamic mechanical compliance to native arteries in vivo. Neoarteries responded to vasomotor agents, albeit with different magnitude than native aortas. These data suggest that an elastic vascular graft that resorbs quickly has potential to improve the performance of vascular grafts used in small arteries. This design may also promote constructive remodeling in other soft tissues. 相似文献
106.
Gargi Goswami Ratan Kumar Ankan Sinha Soumen Kumar Maiti Babul Chandra Dutta Harendra Singh Debasish Das 《RSC advances》2019,9(67):39011
A low-cost and scalable harvesting process was demonstrated for Chlorella sp. FC2 IITG, which offered an improved process economy for the production of a microalgal biomass feedstock via (i) the utilization of a cheaper commercial grade chemical flocculant; (ii) the recycling of post-harvested nutrient-rich spent water for the successive growth of the FC2 cells and (iii) the modulation of the flocculant dose, resulting in the non-requirement of a pH adjustment of the spent water and separate inoculum development step. Ferrous sulphate and ferric chloride were screened from a pool of four commercial grade flocculants, resulting in high harvesting efficiencies of 99.83% and 99.93% at the lower flocculant doses (g of flocculant g of dry biomass−1) of 2.5 and 3, respectively. The effect of the recycled nutrient-rich spent water and treated non-flocculated microalgal cells after harvesting was evaluated for the growth performance of the FC2 cells in six successive batches. It was found that ferrous sulphate was superior over ferric chloride in terms of the recyclability of the spent water for more number of batches, offering similar growth kinetics and nutrient recovery efficiency as compared with that of the control sample. The scale-up feasibility of the harvesting process was evaluated with a 5 L photobioreactor under indoor conditions and a 350 L open raceway pond under outdoor conditions with a modulated flocculant dose of 1.5 g ferrous sulphate. g dry biomass−1. The harvesting cost of 1 kg biomass using commercial grade ferrous sulphate was estimated to be in the range of 0.17–0.3 USD and was significantly lower as compared to that of analytical grade ferrous sulphate.A low-cost and scalable microalgal harvesting process with high harvesting efficiency has been demonstrated using a commercial flocculant and spent-water recycling. 相似文献
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Shizuka Otsuka Nicolas Melis Matthias M. Gaida Debjani Dutta Roberto Weigert Jonathan D. Ashwell 《The Journal of clinical investigation》2021,131(11)
Inhibitors of calcineurin phosphatase activity (CNIs) such as cyclosporin A (CsA) are widely used to treat tissue transplant rejection and acute graft-versus-host disease (aGVHD), for which inhibition of gene expression dependent on nuclear factor of activated T cells (NFAT) is the mechanistic paradigm. We recently reported that CNIs inhibit TCR-proximal signaling by preventing calcineurin-mediated dephosphorylation of LckS59, an inhibitory modification, raising the possibility of another mechanism by which CNIs suppress immune responses. Here we used T cells from mice that express LckS59A, which cannot accept a phosphate at residue 59, to initiate aGVHD. Although CsA inhibited NFAT-dependent gene upregulation in allo-aggressive T cells expressing either LckWT or LckS59A, it was ineffective in treating disease when the T cells expressed LckS59A. Two important NFAT-independent T cell functions were found to be CsA-resistant in LckS59A T cells: upregulation of the cytolytic protein perforin in tissue-infiltrating CD8+ T cells and antigen-specific T/DC adhesion and clustering in lymph nodes. These results demonstrate that effective treatment of aGVHD by CsA requires NFAT-independent inhibition of TCR signaling. Given that NFATs are widely expressed and off-target effects are a major limitation in CNI use, it is possible that targeting TCR-associated calcineurin directly may provide effective therapies with less toxicity. 相似文献
110.
Metal sulfides are gaining prominence as conversion anode materials for lithium/sodium ion batteries due to their higher specific capacities but suffers from low stability and reversibility issues. In this work, the electrochemical properties of CuS anode material has been successfully enhanced by its composite formation using graphitic carbon nitride (g-C3N4). The CuS nanoparticles are distributed evenly in the exfoliated g-C3N4 matrix rendering higher electronic conductivity and space for volume alterations during the repeated discharge/charge cycles. The 0.8CuS:0.2g-C3N4 composite when used as an anode for lithium ion coin cell exhibits a reversible capacity of 478.4 mA h g−1 at a current rate of 2.0 A g−1 after a run of 1000 cycles which is better than that reported for CuS composites with any other carbon-based matrix. The performance is equally impressive when 0.8CuS:0.2g-C3N4 composite is used as an anode in a sodium ion coin cell and a reversible capacity of 408 mA h g−1 is obtained at a current rate of 2.0 A g−1 after a run of 800 cycles. A sodium ion full cell with NVP cathode and 0.8CuS:0.2g-C3N4 composite anode has been fabricated and cycled for 100 runs at a current rate of 0.1 A g−1. It can be inferred that the g-C3N4 matrix improves the ion transfer properties, alleviates the volume alteration happening in the anode during the discharge/charge process and also helps in preventing the leaching of polysulfides generated during the electrochemical process.Metal sulfides are gaining prominence as conversion anode materials for lithium/sodium ion batteries due to their higher specific capacities but suffers from low stability and reversibility issues. 相似文献