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981.
982.
Sajeel Chowdhary MD Lisa M. Chalmers PA-C Marc Chamberlain MD 《Journal of neuroimaging》2007,17(1):69-73
In the course of 1 year at a tertiary cancer center, 3 patients (2 men; 1 woman; age 51-75 years) were seen in neurological consultation (1.5% of all consultations). Clinical course in all patients was of a progressive neurologic disorder not consistent with either a primary or secondary malignancy. Magnetic resonance (MR) imaging was most informative with respect to diagnosis and subsequent management. Brain biopsy was performed in all patients to assist in both diagnosis and prognostication. All patients were determined to have progressive multifocal leukoencephalopathy (PML) by brain biopsy. 相似文献
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Claudia Trenkwalder MD Heike Benes MD Ludger Grote MD Svenja Happe MD Birgit Högl MD Johannes Mathis MD Gerda M. Saletu‐Zyhlarz MD Ralf Kohnen PhD CALDIR study group 《Movement disorders》2007,22(5):696-703
We report the first large-scale double-blind, randomly assigned study to compare two active dopaminergic therapies for Restless Legs Syndrome (RLS), the dopamine agonist cabergoline (CAB) and levodopa/benserazide (levodopa). Patients with idiopathic RLS were treated with fixed daily doses of 2 or 3 mg CAB or 200 or 300 mg levodopa for 30 weeks. Efficacy was assessed by changes in the IRLS (International RLS Severity Scale) and by time to discontinuation of treatment due to loss of efficacy or augmentation. 361 of 418 screened patients (age 58 +/- 12 years, 71% females) were randomly assigned and treated (CAB: n = 178; levodopa: n = 183) in 51 centers of four European countries. Baseline IRLS total score was 25.7 +/- 6.8. The baseline-adjusted mean change from baseline to week 6 in IRLS sum score was d = -16.1 in the CAB group and d = -9.5 in the levodopa group (d = -6.6, P < 0.0001). More patients in the levodopa group (24.0%) than in the CAB group (11.9%, P = 0.0029, log-rank test) discontinued because of loss of efficacy (14.2% vs. 7.9%, P = 0.0290) or augmentation (9.8% vs. 4.0%, P = 0.0412). Adverse events (AEs) occurred in 83.1% of the CAB group and in 77.6% of the levodopa group. In both groups, most frequent AEs were gastrointestinal symptoms (CAB: 55.6%, levodopa: 30.6%, P < 0.0001). This first large-scale active controlled study in RLS showed superior efficacy of cabergoline versus levodopa after a 30-week long-term therapy. Tolerability was found more favorable with levodopa than with cabergoline. 相似文献
984.
The effects of cardiovascular disease are substantial in women, yet cardiovascular preventive therapies for women are underused.
The prevalence and impact of many coronary risk factors differ by gender. Coronary risk interventions (eg, using aspirin)
have diverse outcomes in women and men. Results from studies of preventive interventions specific to women (eg, menopausal
hormone therapy) have changed preventive recommendations and clinical practice. 相似文献
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Postprostatectomy incontinence in men is a devastating condition impacting the quality of life profoundly. Various types of
male sling procedures have been introduced over the years. The bone-anchored male sling appears to be effective and safe in
intermediate-term follow-up. It is certainly more effective than collagen implant and may provide an alternative treatment
option in patients with mild to moderate incontinence. In the short term, other novel procedures seem promising. In spite
of new technology, the artificial urinary sphincter continues to provide high patient satisfaction and cure rates. 相似文献