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21.
Observations in humans suggest that the initial use of tobacco occurs in close temporal proximity to experimentation with
alcohol. There have been relatively few research reports, however, examining possible interactions between these two agents.
The present experiments examined the effect of nicotine exposure on the acquisition of ethanol drinking behavior in a limited
access procedure. In experiment 1, rats were presented with 1-h access to ethanol solutions of increasing concentration for
a period of 20 days. Subcutaneous injections of nicotine (0.6 or 1.2 mg/kg salt) or vehicle were administered 30 min prior
to each ethanol presentation. Experiment 2 used a similar method, but rats were presented with water along with ethanol during
the 1-h test session. Mecamylamine, a nicotinic receptor antagonist, was administered 30 min prior to the nicotine treatment.
Nicotine was seen to produce a dose-dependent increase in ethanol drinking behavior which commenced at the 5% ethanol concentration
and continued at 8% and again at 10%. In the second experiment, mecamylamine was observed to block completely the nicotine-induced
increase in ethanol drinking behavior. The findings suggest that exposure to nicotine can facilitate the acquisition of ethanol
drinking behavior in naive rats and that this effect is mediated by nicotine’s interaction at the nicotinic-cholinergic receptor.
Received: 11 June 1998 / Final version: 1 October 1998 相似文献
22.
Nicotine dependence and likelihood of quitting smoking 总被引:3,自引:0,他引:3
Rodger P. Pinto David B. Abrams Peter M. Monti Stephane I. Jacobus 《Addictive behaviors》1987,12(4):371-374
This study examined the hypothesis that high nicotine dependent smokers would have more difficulty with initial cessation of smoking than low dependent smokers as measured by the Fagerstrom Tolerance Questionnaire (FTQ). Two replications of a nicotine-fading smoking program were conducted at different worksites. Significantly less heavily dependent smokers quit smoking during treatment. The correlation between the FTQ and smoking rate at posttreatment remained even when the pretreatment rate of smoking was partialled out. It was concluded that the concept of nicotine dependence should be re-examined especially in the context of improving the quit rates of behavioral programs at the worksite. 相似文献
23.
Sofiene Rekik Stephane AndrieuFalah Aboukhoudir MD Pierre BarnayGonzalo Quaino MD Michel PansieriJean Lou Hirsch MD 《The Journal of emergency medicine》2012
Background: Acute coronary syndromes after hymenoptera stings and other environmental exposures are referred to as the Kounis syndrome or allergic myocardial ischemia and infarction. Case Report: We report the case of a 58-year-old man with transient inferior ST-segment elevation consistent with myocardial ischemia after a single wasp sting. Urgent cardiac catheterization revealed normal coronary arteries with a normal left ventriculogram. The evaluation and treatment of cardiac ischemia associated with an allergic reaction is discussed. Conclusion: ST elevation myocardial infarction after wasp envenomation is an exceptional and interesting pathology with a partially elucidated pathogenesis. The management of cardiac ischemia in this setting is uncertain. 相似文献
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Stephane M Shepherd Stefan Luebbers James R. P. Ogloff Rachael Fullam 《Psychiatry, Psychology and Law》2013,20(5):801-817
Validation literature on the predictive ability of North American youth violence risk assessment inventories is developing across international settings. Yet no information exists on the utility of the Structured Assessment of Violence Risk in Youth (SAVRY) and the Psychopathy Checklist: Youth Version (PCL:YV),]and little research has been conducted on the Youth Level of Service/Case Management Inventory (YLS/CMI) across Australian young offender populations. The current study investigated the validity of the risk instruments on 213 young people in detention in Victoria, Australia. Findings indicated moderate to strong predictive accuracy for re-offence outcomes across the three inventories for the total sample and for males. The SAVRY was also able to identify the strength of protective factors for young female offenders. The inventories appear to be suitable prediction aides in the Australian youth justice context although further research is required to ascertain their applicability to Australian young female offenders. 相似文献
26.
Eva Compérat Stéphane Larré Morgan Roupret Yann Neuzillet Géraldine Pignot Hervé Quintens Nadine Houéde Catherine Roy Xavier Durand Justine Varinot Dimitri Vordos Mathieu Rouanne Mohammed Adnan Bakhri Priscilla Bertrand Stephane Calin Jeglinschi Olivier Cussenot Michel Soulié Christian Pfister 《Virchows Archiv : an international journal of pathology》2015,466(5):589-594
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Red and far‐red fluorescent dyes for the characterization of head and neck cancer at the cellular level
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