Exposure to nicotine enhances acquisition of ethanol drinking by laboratory rats in a limited access paradigm

 Observations in humans suggest that the initial use of tobacco occurs in close temporal proximity to experimentation with alcohol. There have been relatively few research reports, however, examining possible interactions between these two agents. The present experiments examined the effect of nicotine exposure on the acquisition of ethanol drinking behavior in a limited access procedure. In experiment 1, rats were presented with 1-h access to ethanol solutions of increasing concentration for a period of 20 days. Subcutaneous injections of nicotine (0.6 or 1.2 mg/kg salt) or vehicle were administered 30 min prior to each ethanol presentation. Experiment 2 used a similar method, but rats were presented with water along with ethanol during the 1-h test session. Mecamylamine, a nicotinic receptor antagonist, was administered 30 min prior to the nicotine treatment. Nicotine was seen to produce a dose-dependent increase in ethanol drinking behavior which commenced at the 5% ethanol concentration and continued at 8% and again at 10%. In the second experiment, mecamylamine was observed to block completely the nicotine-induced increase in ethanol drinking behavior. The findings suggest that exposure to nicotine can facilitate the acquisition of ethanol drinking behavior in naive rats and that this effect is mediated by nicotine’s interaction at the nicotinic-cholinergic receptor. Received: 11 June 1998 / Final version: 1 October 1998     

Nicotine dependence and likelihood of quitting smoking

This study examined the hypothesis that high nicotine dependent smokers would have more difficulty with initial cessation of smoking than low dependent smokers as measured by the Fagerstrom Tolerance Questionnaire (FTQ). Two replications of a nicotine-fading smoking program were conducted at different worksites. Significantly less heavily dependent smokers quit smoking during treatment. The correlation between the FTQ and smoking rate at posttreatment remained even when the pretreatment rate of smoking was partialled out. It was concluded that the concept of nicotine dependence should be re-examined especially in the context of improving the quit rates of behavioral programs at the worksite.     

ST Elevation Myocardial Infarction With No Structural Lesions After a Wasp Sting

Background: Acute coronary syndromes after hymenoptera stings and other environmental exposures are referred to as the Kounis syndrome or allergic myocardial ischemia and infarction. Case Report: We report the case of a 58-year-old man with transient inferior ST-segment elevation consistent with myocardial ischemia after a single wasp sting. Urgent cardiac catheterization revealed normal coronary arteries with a normal left ventriculogram. The evaluation and treatment of cardiac ischemia associated with an allergic reaction is discussed. Conclusion: ST elevation myocardial infarction after wasp envenomation is an exceptional and interesting pathology with a partially elucidated pathogenesis. The management of cardiac ischemia in this setting is uncertain.     

The Predictive Validity of Risk Assessment Approaches for Young Australian Offenders

Validation literature on the predictive ability of North American youth violence risk assessment inventories is developing across international settings. Yet no information exists on the utility of the Structured Assessment of Violence Risk in Youth (SAVRY) and the Psychopathy Checklist: Youth Version (PCL:YV),]and little research has been conducted on the Youth Level of Service/Case Management Inventory (YLS/CMI) across Australian young offender populations. The current study investigated the validity of the risk instruments on 213 young people in detention in Victoria, Australia. Findings indicated moderate to strong predictive accuracy for re-offence outcomes across the three inventories for the total sample and for males. The SAVRY was also able to identify the strength of protective factors for young female offenders. The inventories appear to be suitable prediction aides in the Australian youth justice context although further research is required to ascertain their applicability to Australian young female offenders.