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TA Stupina VD Makushin MA Stepanov 《Bulletin of experimental biology and medicine》2012,153(2):289-293
The articular cartilage was studied under conditions of experimental osteoarthrosis with tunnelization of the subchondral
zone and injection of autologous bone marrow into the channels. Histomorphological studies showed that tunnelization of the
subchondral zone with injection of autologous bone marrow into the channels stimulated reparative regeneration of the chondral
tissue by inhibiting destruction of the joints. 相似文献
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The kinetics of the association and dissociation of the tritium-labeled selective and potent dopamine transporter inhibitor N-(3-iodoprop-2E-enyl)-2β-carbo-[3H]methoxy-3β-(4′-methylphenyl)nortropane ([3H]PE2I) with the transporter of mouse striatal membranes was studied. The analysis revealed that the specific binding of [3H]PE2I occurs within a homogeneous population of binding sites in these membranes. The relatively slow binding process was characterized by the pseudo-first-order rate constant kobs. The plot of these rate constants versus free radioligand concentration was hyperbolic, demonstrating that at least two kinetically distinguishable steps can be identified in the interaction of dopamine transporter with this inhibitor. The fast and reversible binding step, characterized by dissociation constant KA = 51 ± 23 nM, is followed by a slow but also reversible isomerization step of the complex, characterized by the isomerization rate constant ki = (7 ± 2)10−2 s−1 and by the rate constant k−i = (3.9 ± 0.5)10−3 s−1 for the reverse process. This isomerization step increases the apparent affinity of the ligand and probably consists of a conformational transition of the transporter protein, induced by the inhibitor molecule. 相似文献
117.
Baranskaia EK Ivashkin VT Lapshin AV Stepanov EV Zyrianov PV 《Klinicheskaia meditsina》2006,84(8):47-50
The authors present the results of laser-based 13C-urea breath test (13C-UBT) application in diagnostics of Helicobacter pylori-associated diseases (chronic gastritis, duodenitis, and peptic ulcer). 13C-UBT data distribution before and after eradication therapy, as well as age distribution, were obtained. Correlations between the nosological forms and the rate of contamination were established. 相似文献
118.
A. V. Shvetsov E. G. Batotsyrenova S. V. Stepanov M. B. Ivanov 《Neurochemical Journal》2016,10(4):308-311
The markers of impairments of the nervous system were evaluated in rats at various time points after a sodium thiopental injection at the LD50 using biochemical and immunohistochemical methods. The thiopental coma state was associated with a decrease in the levels of superoxide dismutase 6 h after the injection, glucose-6-phosphate dehydrogenase 24 and 72 h after the injection, and pigment epithelium-derived factor 6?2 h after the injection, as well an increase in the levels of glutathione peroxidase 72 h after the injection and caspase-3 6 h after the injection in the blood plasma of rats. Immunohistochemical study of caspase-3 in the brain tissue revealed increased expression of the enzyme in the sensorimotor cortex and hippocampus 3 days after the thiopental injection. 相似文献
119.
Novel sensitive analytical agents that can be used for simple, affordable, and rapid analysis of mycotoxins are urgently needed in scientific practice, especially for the screening of perspective bio-destructors of the toxic contaminants. We compared the characteristics of a rapid quantitative analysis of different mycotoxins (deoxynivalenol, ochratoxin A, patulin, sterigmatocystin, and zearalenone) using acetyl-, butyrylcholinesterases and photobacterial strains of luminescent cells in the current study. The best bioindicators in terms of sensitivity and working range (μg/mL) were determined as follows: Photobacterium sp. 17 cells for analysis of deoxynivalenol (0.8–89) and patulin (0.2–32); Photobacterium sp. 9.2 cells for analysis of ochratoxin A (0.4–72) and zearalenone (0.2–32); acetylcholinesterase for analysis of sterigmatocystin (0.12–219). The cells were found to be more sensitive than enzymes. The assayed strains of photobacterial cells ensured 44%–83% lower limit of detection for deoxynivalenol and sterigmatocystin as compared to the previously known data for immobilized luminescent cells, and the range of working concentrations was extended by a factor of 1.5–3.5. Calibration curves for the quantitative determination of patulin using immobilized photobacteria were presented in this work for the first time. This calibration was applied to estimate the enzyme efficiency for hydrolyzing mycotoxins using zearalenone and His6-tagged organophosphorus hydrolase as examples. 相似文献
120.
Konstantinos?Chiotis Per?Stenkrona Ove?Almkvist Vladimir?Stepanov Daniel?Ferreira Ryosuke?Arakawa Akihiro?Takano Eric?Westman Andrea?Varrone Nobuyuki?Okamura Hitoshi?Shimada Makoto?Higuchi Christer?Halldin Agneta?NordbergEmail author 《European journal of nuclear medicine and molecular imaging》2018,45(9):1605-1617