The theatrical dimension of suicide]

"Theatrical" is a term that in psychiatry mostly has a discredited connotation and that is often disparaged. This work means to assign to suicide's and attempted suicide's "theatrical dimension", a different side, showing theatricality as a very important communicative, creative and vital force.     

Case report: Treatment failure using propanolol for treatment of focal subglottic hemangioma

Subglottic hemangioma is a rare, potentially life threatening tumor of infancy which poses serious treatment challenges. A number of medical and surgical therapies over the years have met with variable success, and are associated with numerous potential morbidities. A potential windfall in the management of infantile hemangiomas has arisen with the recent identification of propanolol as a highly efficacious and relatively safe new treatment modality. At least five reports in the literature have described the rapid, successful treatment of airway hemangiomas with oral propanolol. We describe the first reported treatment failure with propanolol for subglottic hemangioma in an infant who initially responded dramatically to the medication.     

Physicians' views on resource availability and equity in four European health care systems

Background  

In response to limited resources, health care systems have adopted diverse cost-containment strategies and give priority to differing types of interventions. The perception of physicians, who witness the effects of these strategies, may provide useful insights regarding the impact of system-wide priority setting on access to care.     

Basal progesterone level as the main determinant of progesterone elevation on the day of hCG triggering in controlled ovarian stimulation cycles

Purpose

Modest increases of serum progesterone at human chorionic gonadotrophin (hCG) administration in controlled ovarian hyperstimulation (COH) cycles have been shown to have a negative impact on pregnancy outcomes. The aim of this study was to identify early predictors of progesterone elevation at hCG.

Design

Pregnancy outcome of 303 consecutive patients undergoing COH and fresh day-3 embryo transfer was analysed. Considering the non-linear relationship between progesterone at hCG triggering and pregnancy outcomes, partial area under the curve (pAUC) analysis was used to implement marker identification potential of receiver operating characteristic (ROC) curve analysis. Multivariate logistic analysis was then performed to identify predictors of progesterone rise.

Results

Pregnancy outcomes could be predicted by pAUC analysis (pAUC = 0.58, 95 % CI 0.51–0.66, p = 0.02) and a significant detrimental cut-off could be calculated (progesterone at hCG > 1.35 ng/ml). Total dose of rFSH administered, E₂ level at hCG but mostly basal progesterone level (OR = 12.21, 95 % CI 1.82–81.70) were predictors of progesterone rise above the cut-off.

Conclusion

Basal progesterone is shown to be the main prognostic factor for progesterone elevation. This observation should be taken into consideration in the clinical management of IVF/ICSI cycles to improve pregnancy outcomes.     

An experimental investigation into the effect of periodic motion on proton dosimetry using polymer gel dosimeters and a programmable motion platform

Organ motion in proton therapy affects treatment dose distribution during both double-scattering (DS) and uniform-scanning (US) deliveries. We investigated the dosimetric impact of target motion using three-dimensional polymer gel dosimeters and a programmable motion platform. A simple one-beam treatment plan with 16 cm range and 6 cm modulation was generated from the treatment planning system (TPS) in both the DS and US modes. One gel dosimeter was irradiated with a stationary DS beam. Two other gel dosimeters were irradiated with the DS and US beams while they moved in the same sinusoidal motion profile using a programmable motion platform. The dose distribution of the stationary DS delivery agreed with the TPS plan. Dosimetric comparisons between DS motion delivery and the MATLAB-based motion model showed insignificant differences. Dose-volume histograms of a cylindrical target volume inside the gel dosimeters showed target coverage degradation caused by motion. A three-dimensional gamma index calculation (3% and 3 mm) confirmed different dosimetric impacts from DS and US with the same target motion. This polymer-gel-dosimeter-based study confirmed the dosimetric impact of intrafraction target motion and its interplay with temporal delivery of different energy layers in US proton treatments.     

On the Etiology of Type 1 Diabetes: A New Animal Model Signifying a Decisive Role for Bacteria Eliciting an Adverse Innate Immunity Response

The cause of type 1 diabetes (T1D) remains unknown; however, a decisive role for environmental factors is recognized. The increased incidence of T1D during the last decades, as well as regional differences, is paralleled by differences in the intestinal bacterial flora. A new animal model was established to test the hypothesis that bacteria entering the pancreatic ductal system could trigger β-cell destruction and to provide new insights to the immunopathology of the disease. Obtained findings were compared with those present in two patients dying at onset of T1D. Different bacterial species, present in the human duodenum, instilled into the ductal system of the pancreas in healthy rats rapidly induced cellular infiltration, consisting of mainly neutrophil polymorphonuclear cells and monocytes/macrophages, centered around the pancreatic ducts. Also, the islets of Langerhans attracted polymorphonuclear cells, possibly via release of IL-6, IL-8, and monocyte chemotactic protein 1. Small bleedings or large dilatations of the capillaries were frequently found within the islets, and several β-cells had severe hydropic degeneration (ie, swollen cytoplasm) but with preserved nuclei. A novel rat model for the initial events in T1D is presented, revealing marked similarities with the morphologic findings obtained in patients dying at onset of T1D and signifying a decisive role for bacteria in eliciting an adverse innate immunity response. The present findings support the hypothesis that T1D is an organ-specific inflammatory disease.Our understanding of the etiology of type 1 diabetes (T1D) remains limited and originates to a large extent from two animal models: the nonobese diabetic mouse and the BioBreeding-diabetes prone rat.¹ In both models a progressive T-cell–mediated destruction of the β-cells occurs; however, the immunopathologic findings reveal limited similarities with the human disease.^2–5 In human pancreatic specimens, insulitis is discrete, affects only a few islets, and is heterogeneously distributed within the gland. In a recent meta-analysis, insulitis was reported in only 29% of patients with onset between 15 and 39 years of age and with a disease duration of <1 month.⁶ At the time of diagnosis, autoantibodies were only present in approximately 70% to 80% of affected patients.⁷ Likewise, attempts to prevent disease progression with immunosuppression^8–11 or immunointerventions^12–14 cause no or only transient preservation of β-cell function.The fact that the exocrine pancreas gets affected in patients with T1D is underappreciated, and several studies have found autoantibodies in the exocrine cells before the onset of T1D.^15–18 Mild to moderate exocrine pancreatic insufficiency is an early event in T1D,¹⁹ and a substantial reduction (32%) in pancreatic volume is already present 3 to 4 months after onset.²⁰ Also, in the classic report by Gepts,⁴ lesions of the acinar tissue were reported to occur frequently in patients with recent onset of T1D. The findings comprised mostly focal or diffuse lesions of acute pancreatitis with accumulation of leukocytes, often centered around the excretory canals.^2–5 In a more recent study of patients with long-term T1D, 40% had periductal fibrosis and 60% of cases had periductal fibrosis that extended to the interlobular pancreas.²¹ Collectively, these observations suggest that the injurious process that causes T1D affects both the exocrine and endocrine components of the pancreas and challenge the view that T1D is a β-cell–specific autoimmune disease.The low concordance rate for the development of T1D in identical twins and the current rapid increase in incidence of T1D argue against a decisive role for genetic factors. Notably, there is a close to sixfold gradient in the incidence of T1D between Russian and Finland Karelia, although the population is homogenous and the predisposing HLA genotypes are equally frequent.²² In addition, children born in Finland by immigrants from Somalia, a low incidence country for T1D, acquire the same risk for T1D as the native Finish population.²³ On the basis of these and similar observations, it is generally assumed that environmental factors may act as triggers of T1D. For decades different enteroviruses have been implicated in the pathogenesis of T1D²⁴; however, evidence of causality remains missing.Bacterial colonization of the infantile gut is influenced by environmental factors and has changed markedly in developed countries during the last decades.²⁵ Interestingly, the increased incidence of T1D²⁶ and the difference in incidence of T1D in Sweden, Italy, and Africa^26–28 are paralleled by reported frequencies of intestinal Staphylococcus aureus.^29–32 Bacteria entering the ductal system of the pancreas would be exposed to the pancreatic juice–containing substances, with marked antibacterial effects initiating release of bacterial components, such as lipopolysaccharide (LPS), lipoteichoic acid (LTA), and various toxins. Notably, these substances have been implicated in the etiology of neurogenerative diseases and neural cell death because they stimulate microglia to produce proinflammatory cytokines (IL-1b, IL-6, tumor necrosis factor-α), nitric oxide, and reactive oxygen species, causing significant cell death in neighboring neural cells.³³The present study was conducted to establish an animal model for the initial events in T1D to test the hypothesis that bacteria entering into the ductal system of the pancreas could elicit an adverse innate immunity response. Different bacterial species present transiently or continuously in the human duodenum were instilled into the ductal system of the pancreas in healthy rats. To examine the clinical relevance of the experimental model, obtained findings were compared with those present in the pancreases of two patients dying at onset of T1D.