全文获取类型
收费全文 | 1133篇 |
免费 | 85篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 32篇 |
妇产科学 | 61篇 |
基础医学 | 91篇 |
口腔科学 | 9篇 |
临床医学 | 49篇 |
内科学 | 194篇 |
皮肤病学 | 4篇 |
神经病学 | 6篇 |
特种医学 | 69篇 |
外科学 | 630篇 |
综合类 | 26篇 |
预防医学 | 8篇 |
眼科学 | 2篇 |
药学 | 18篇 |
中国医学 | 3篇 |
肿瘤学 | 15篇 |
出版年
2016年 | 6篇 |
2015年 | 6篇 |
2013年 | 10篇 |
2012年 | 6篇 |
2010年 | 5篇 |
2009年 | 5篇 |
2008年 | 10篇 |
2007年 | 15篇 |
2006年 | 13篇 |
2005年 | 12篇 |
2004年 | 9篇 |
2003年 | 9篇 |
2002年 | 13篇 |
2001年 | 21篇 |
2000年 | 31篇 |
1999年 | 46篇 |
1998年 | 23篇 |
1997年 | 22篇 |
1996年 | 20篇 |
1995年 | 27篇 |
1994年 | 21篇 |
1993年 | 33篇 |
1992年 | 71篇 |
1991年 | 119篇 |
1990年 | 92篇 |
1989年 | 77篇 |
1988年 | 60篇 |
1987年 | 48篇 |
1986年 | 36篇 |
1985年 | 39篇 |
1984年 | 21篇 |
1983年 | 22篇 |
1982年 | 7篇 |
1980年 | 11篇 |
1979年 | 17篇 |
1978年 | 13篇 |
1977年 | 17篇 |
1976年 | 6篇 |
1975年 | 12篇 |
1974年 | 9篇 |
1973年 | 14篇 |
1972年 | 17篇 |
1971年 | 21篇 |
1970年 | 24篇 |
1969年 | 12篇 |
1968年 | 17篇 |
1967年 | 11篇 |
1966年 | 11篇 |
1957年 | 6篇 |
1954年 | 5篇 |
排序方式: 共有1219条查询结果,搜索用时 15 毫秒
91.
Starzl TE Murase N Demetris AJ Trucco M Abu-Elmagd K Gray EA Eghtesad B Shapiro R Marcos A Fung JJ 《Transplantation》2004,77(6):926-929
Although the reductionist approach has served science well for 400 years, the accumulation of details can obscure the truth if the original premise is incorrect. One such premise has been that successful organ transplantation and bone marrow engraftment are fundamentally different outcomes involving separate and distinct mechanisms. Some historical clinical observations pointed to a different conclusion almost from the beginning and included clues about how to induce tolerance with the aid of immunosuppression. 相似文献
92.
Pregnancy after liver transplantation with tacrolimus immunosuppression: a single center's experience update at 13 years 总被引:11,自引:0,他引:11
Jain AB Reyes J Marcos A Mazariegos G Eghtesad B Fontes PA Cacciarelli TV Marsh JW de Vera ME Rafail A Starzl TE Fung JJ 《Transplantation》2003,76(5):827-832
BACKGROUND: Chronic liver disease often leads to amenorrhea in women of childbearing age. There are several reports of successful pregnancy after liver transplantation (LTx) with cyclosporine A immunosuppression. Tacrolimus has been increasingly used in solid-organ transplantation, and the effect of the drug on pregnancy is still of interest to clinicians. This study updates our single-center experience. METHODS: All pregnancies after LTx with tacrolimus immunosuppression were followed prospectively. Patients' clinical courses during pregnancy and labor along with gestational period and birth weight were catalogued. Changes in liver function, renal function, and immunosuppression also were recorded. The birth weight percentile was calculated on the basis of the gestational period using a standard chart. RESULTS: Thirty-seven mothers delivered 49 babies. Three mothers delivered three times, and six mothers delivered two times. Thirty-six mothers (97%) survived the pregnancy, and 36 allografts (97%) survived. The one death and graft loss was in a patient who demonstrated infra-aortic arterial graft, which clotted by the gravid uterus during labor. The patient developed a gangrenous liver and died before she could undergo retransplantation. The mean gestational period was 36.4+/-3.2 weeks, excluding two premature deliveries at 23 and 24 weeks gestation. Twenty-two babies (46.9%) were delivered by cesarean section, and the other babies were delivered vaginally. In addition to the two premature babies, one baby, who was born to a mother with Alagille syndrome, died from congenital birth defects. The rest of the newborns survived. The mean birth weight was 2,797+/-775 g, with 38 babies (78%) weighing more than 2,000 g. The mean birth weight percentile to gestational period was 54+/-23. Four babies (8.5%) had a birth weight percentile of less than 25, and 28 babies (59.6%) had a birth weight percentile greater than 50. Twelve patients demonstrated an increase in hepatic enzymes without jaundice during the pregnancy. All of them responded to augmentation of immunosuppression. CONCLUSION: The present report reconfirms the safety of tacrolimus during pregnancy after LTx. Preterm delivery and low birth weight seem to be a persistent problem in all solid-organ transplantation under any form of immunosuppression. However, toxemia of pregnancy and new onset of hypertension seem to be have a low occurrence with the use of tacrolimus. 相似文献
93.
94.
95.
96.
97.
BP O’Neill TM Habermann TE Witzig M Rodriguez 《Medical oncology (Northwood, London, England)》1999,16(3):211-215
Five patients at risk for primary central nervous system lymphoma (PCNSL) recurrence were treated with high-dose methylprednisolone (HDMP) to prevent 'trafficking' of malignant lymphocytes into the central nervous system (CNS). HDMP was chosen because of its ability to stabilize the 'blood brain barrier (BBB)'. Three men with newly diagnosed PCNSL, ages 62, 76 and 78y, whose survival was projected to be 6.6 months, began treatment after achieving complete response (CR) to initial radiation therapy alone and survived 27, 37 and 59 months after treatment. In none was death from recurrent disease in CNS but one patient did die of systemic non-Hodgkin's lymphoma (NHL) five years after PCNSL diagnosis. A 20 y old man was treated with HDMP after successful combined modality therapy and is alive 75+ months after initial diagnosis without evidence of disease recurrence. A 34 y old man relapsed after combined modality initial treatment and failed to respond to HDMP when treatment was begun after unsuccessful salvage therapy; he died of disease 12 months after initial diagnosis. There were no treatment complications. The promising results in this pilot study from the basis for a North Central Cancer Treatment Group (NCCTG) 96-73-51, a Phase 2 clinical trial of brain radiotherapy and HDMP for PCNSL patients 70y of age and older, a group of patients at high risk for toxicity from intensive combined modality therapy. 相似文献
98.
A G Tzakis R D Gordon L Makowka C O Esquivel S Todo S Iwatsuki T E Starzl 《Radiologic clinics of North America》1987,25(2):289-297
Progress in immunosuppression, surgical techniques, and perioperative care has promoted orthotopic liver transplantation from an experimental procedure to an accepted clinical treatment. Orthotopic liver transplantation, in turn, has changed the treatment of terminal liver disease from care that is largely treatment of symptoms and support to cure, but at the price of major surgery and life-long immunosuppression. This article reviews the current status of liver transplantation as practiced at the University of Pittsburgh. 相似文献
99.
100.
Biliary tract complications in human orthotopic liver transplantation 总被引:11,自引:0,他引:11
J Lerut R D Gordon S Iwatsuki C O Esquivel S Todo A Tzakis T E Starzl 《Transplantation》1987,43(1):47-51
The results of 393 consecutive orthotopic liver transplants in 313 patients were reviewed to determine the incidence of primary biliary tract complications. There were 52 biliary tract complications in 393 grafts (13.2%), and 5 directly related deaths. Choledochojejunostomy over an internal stent to a Roux-en-Y limb of proximal jejunum (RYCJ-S) was the most frequently used technique (175 cases) and the most successful with only 9 technical failures (5.2%). Choledochocholedochostomy over a T tube (CC-T) was used in 159 cases and was successful in all but 20 cases (12.6%). Other methods of reconstruction were associated with high failure rates or technical complexity that do not justify their use. Biliary leak and obstruction were the most common complications. Leakage after CC-T at the T tube exit site was usually directly repaired, but anastomotic leakage required conversion to RYCJ-S. Obstruction may be relieved by percutaneous balloon dilatation but definitive treatment also usually required conversion to RYCJ-S. The most common complication after RYCJ-S is functional obstruction by a retained stent, which has a low morbidity but may necessitate surgical removal. Anastomotic leaks, which occurred in 2 cases, were successfully managed by revision of the choledochojejunostomy. 相似文献