健胃愈疡颗粒对消化性溃疡大鼠胃黏膜PS2和PAF表达的影响

目的研究健胃愈疡颗粒对溃疡的影响，并探讨其机制。方法以Okabe改良法复制大鼠实验性胃溃疡，观察其对溃疡指数和胃黏膜血流的影响，并用RT—PCR观察乳癌相关肽PS2和血小板活化因子（PAF）表达的变化。结果健胃愈疡颗粒能提高PS2mRNA和下调PAFmRNA的表达，明显降低溃疡指数，促进溃疡愈合。结论健胃愈疡颗粒可通过提高PS2mRNA和下调PAFmRNA的表达，通过影响胃黏膜疏水性，加强黏液凝胶层稳定性，从而防止溃疡的产生和复发，这可能是其促进溃疡愈合的机制之一。     

关于中药血清药理学方法的再思考

血清的形成与凝血及其相关过程（纤溶与补体系统活化）的蛋白酶级联反应以及血小板和白细胞活化有关，这些过程直接影响血标本的组成，并可能也影响中药成分；但这些过程可用抗凝剂而加以避免。因此，血浆的组成较血清能更好地反映生理、病理状况和吸收进入循环血中药物变化。根据已有报道，药物浓度与反应物质在血浆与血清中可能存在差异，故倡导在中药半体内实验中采用血浆药理学方法。由于不同抗凝剂的作用机制各异，究竟哪一抗凝剂适用于哪类半体内实验，需要进一步开展研究。我们建议在大多数中药半体内实验中，可以采取含药血浆与含药血清平行观察，除非事先对该试验的干扰已有充分了解。     

徐金合剂治疗白塞氏病眼部病变106例临床分析

自1972年,我科用中药徐金合剂治疗白塞氏病并发眼病106例,多数为中青年,眼并发症主要有葡萄膜炎和视网膜血管病变(77.68％),近期疗效的有效率和显效率各占86.79％和57.55％,长期持续治疗有效率93.44％,显效率为75.41％,失明率3.28％,与停药对照组比较有显著差异。     

人工肝的研究进展

叙述了人工肝研究情况     

HIV-1 subtype J recombinant viruses in Spain

Genetic characterization of HIV-1 was carried out in two women who originated in Cameroon and Equatorial Guinea, respectively, and who were diagnosed more recently as HIV-1 seropositive in Madrid, Spain. Phylogenetic studies showed that the protease-encoding gene from both individuals clustered with subtype J sequences with a high bootstrap. However, env sequences clustered with subtypes A and C, respectively. This work represents the first characterization of HIV-1 containing subtype J-like genomic regions in Spain.     

Strategies to identify disease genes

The correlation between genes and disease began in earnest in the early 1900s with the identification of Mendelian-like inheritance of "inborn errors of metabolism." Since then, the ever-broadening field of genetics has been established as one of the most important and groundbreaking branches of science and medicine to date. With the announcement of a "working draft" sequence of the human genome in 2001, the vast array of both genomic and expressed sequence information available in the public databases alone has meant that the concept of hunting for genes is evolving. Nowadays, researchers can substitute many labor-intensive hours in the lab for less time searching on the World Wide Web. Specialization within genetics has been continuously providing subsets of the genre such as genomics, pharmacogenetics, chemogenomics, gene therapy, proteomics and functional genomics, all of which are based on the fundamental starting block, the gene. This review aims to summarize both traditional and current strategies for identifying susceptibility and monogenetic disease genes and describes how these strategies have evolved in tune with the ever-expanding wealth of information now available at our fingertips.     

抓住重点 不断创新 进一步深化卫生人事制度改革

论述了卫生干部制度改革、事业单位人事制度改革和专业人才队伍建设的思路和措施。指出,要以“三个代表”重要思想为指导,突出党政干部制度改革、事业单位人事制度改革和专业人才队伍建设三个重点,着力解决人员出口和工资分配制度两个难点问题。同时主动配合支援西部和农村卫生的重点工作,稳步推进农村和西部人才资源开发,大力推进卫生人才市场建设。     

Continuity and quality of care in type 2 diabetes: a Residency Research Network of South Texas study

OBJECTIVE: We investigated the relationship between continuity of care and the quality of care received by patients with type 2 diabetes mellitus. STUDY DESIGN: We used a cross-sectional patient survey and medical record review. POPULATION: Consecutive patients with an established diagnosis of type 2 diabetes mellitus presented to 1 of 6 clinics within the Residency Research Network of South Texas, a network of 6 family practice residencies affiliated with the University of Texas Health Science Center at San Antonio. OUTCOMES MEASURED: Continuity was measured as the proportion of visits within the past year to the patient's usual primary care provider. A quality of care score was computed based on the American Diabetes Association's Provider Recognition Program criteria from data collected through medical record review and patient surveys. Each patient was awarded points based on the presence or absence of each criterion. RESULTS: The continuity score was associated significantly with the quality of care score in the anticipated direction (r =.15, P =.04). Patients who had seen their usual providers within the past year were significantly more likely to have had an eye examination, a foot examination, 2 blood pressure measurements, and a lipid analysis. CONCLUSIONS: Continuity of care is associated with the quality of care received by patients with type 2 diabetes mellitus. Continuity of care may influence provider and patient behaviors in ways that improve quality. Further research on how continuity contributes to improved quality is needed.