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71.
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Miyamoto M Kotani K Okada K Fujii Y Konno K Ishibashi S Taniguchi N 《Acta diabetologica》2012,49(1):63-68
The clinical significance of the diameter of the common carotid artery (CCA) measured ultrasonographically in diabetic practice
has not been sufficiently established. The objective of this study was to investigate the relationship of the ultrasonic CCA
diameter with atherosclerotic measures and diabetic retinopathy as a microvascular complication in patients with type 2 diabetes
mellitus (T2DM). This hospital-based cross-sectional study included 102 patients with T2DM (men: 65%, mean age: 57 years)
who had no apparent carotid arterial stenosis and no history of cardiovascular or severe renal disease. The current smoking
status, body mass index, blood pressure, hemoglobin A1c, serum low-density lipoprotein cholesterol, and ultrasonic measures
of carotid arteries (CCA diameter, intima-media thickness (IMT), plaque score) were measured. The cardio-ankle vascular index
(CAVI) and the presence of diabetic retinopathy were also assessed. The CCA diameter showed a significant positive correlation
with the mean IMT or plaque score. The CAVI had a significant positive correlation with the mean IMT, plaque score, and CCA
diameter, while diabetic retinopathy had a significant positive correlation with the CCA diameter, but not the mean IMT or
plaque score. These results were unaltered after adjusting for multiple confounders. The CCA diameter may serve as a useful
marker for atherosclerosis and diabetic retinopathy, and in particular, may be a marker associated with diabetic retinopathy
more clearly than the carotid IMT and plaque score, in patients with T2DM. 相似文献
74.
75.
Coronary artery calcium score (CACS) measured by multi-detector computed tomography, carotid plaque score (CPS) measured by carotid artery ultrasound, and brachial-ankle pulse wave velocity (baPWV) are noninvasive screening tools for coronary artery disease. The aim of this study was to determine whether the combination of CACS, CPS, and baPWV improves the prognostic value for future cardiac events. CACS, CPS, and baPWV were assessed in 77 patients (mean age, 65 years, 49 males) undergoing invasive coronary angiography. ECG-triggered MSCT was used to assess CACS. CPS was defined as the sum of all plaque heights in bilateral carotid arteries. The highest baPWV was used for analysis. Cardiac events were defined as cardiac death, nonfatal myocardial infarction, or coronary revascularization. Thirty-two cardiac events (41.6%) occurred during follow-up (23.6 ± 20.8 months), consisting of 28 PCIs and 4 CABGs. The best cutoff values of positive CACS, CPS, and baPWV for predicting cardiac events were ≥ 50, ≥ 5, and ≥1.6 m/second, respectively. For the combination of the 3 modalities, the positive test was defined as having at least 1 positive result by each method. The negative predictive value of all 3 modalities combined was better than that of CACS alone. The event-free rate was higher in patients with negative results for all 3 parameters compared with those that were positive (100% versus 44.8%, P < 0.0001). The prognostic value of using combined assessment of CACS, CPS, and baPWV is more effective for predicting cardiac events than CACS alone. 相似文献
76.
Tatsuro Misu Romana Höftberger Kazuo Fujihara Isabella Wimmer Yoshiki Takai Shuhei Nishiyama Ichiro Nakashima Hidehiko Konno Monika Bradl Ferenc Garzuly Yasuto Itoyama Masashi Aoki Hans Lassmann 《Acta neuropathologica》2013,125(6):815-827
Neuromyelitis optica (NMO) is an autoimmune disease targeting aquaporin 4 (AQP4), localized mainly at the astrocytic foot processes. Loss of AQP4 and glial fibrillary acidic protein (GFAP) was reported, but the pathological significance of astrocytopathy is still controversial. Here we show that active lesions in NMO display a wide spectrum of pathology even within a single tissue block of an individual patient. We have distinguished six different lesion types. The first reflects complement deposition at the surface of astrocytes, associated with granulocyte infiltration and astrocyte necrosis and followed by demyelination, global tissue destruction and the formation of cystic, necrotic lesions (lesion type 2). Such destructive lesions lead to Wallerian degeneration in lesion-related tracts (lesion type 3). Around active NMO lesions AQP4 may selectively be lost in the absence of aquaporin 1 (AQP1) loss or other structural damage (lesion type 4). Another pattern is characterized by clasmatodendrosis of astrocytes, defined by cytoplasmic swelling and vacuolation, beading and dissolution of their processes and nuclear alterations resembling apoptosis, which was associated with internalization of AQP4 and AQP1 and astrocyte apoptosis in the absence of complement activation. Such lesions give rise to extensive astrocyte loss, which may occur in part in the absence of any other tissue injury, such as demyelination or axonal degeneration (lesion type 5). Finally, lesions with a variable degree of astrocyte clasmatodendrosis are found, which show plaque-like primary demyelination that is associated with oligodendrocyte apoptosis, but with preservation of axons (lesion type 6). In active multiple sclerosis (MS) lesions astrocytes reveal changes of reactive protoplasmatic or fibrillary gliosis. Only in a subset of lesions, in patients with aggressive disease, loss of AQP4 is observed in the initial stage of their formation, which is associated with retraction of astrocyte processes in the absence of complement deposition, granulocyte infiltration or loss of AQP1 or astrocytes. Our data underline the primary assault of astrocytes in NMO lesions, but also indicate that different mechanisms of tissue injury operate in parallel in the same patient and even within the same lesion. 相似文献
77.
Tanaka K Shirakawa H Okada K Konno M Nakagawa T Serikawa T Kaneko S 《Neuroscience letters》2007,426(2):75-80
The ataxic groggy rat (strain name; GRY) is an autosomal recessive neurological mutant found in a closed colony of Slc:Wistar rats. Recent genetic analysis has identified the missense (M251K) mutation in the alpha(1) subunit of the Ca(V)2.1 (P/Q-type) voltage-dependent Ca(2+) channel gene (Cacna1a) of GRY rat. In this study, we found that high-voltage-activated (HVA) Ca(2+) channel currents in acutely dissociated Purkinje cells of GRY rats showed increased (not decreased) current density and depolarizing shift of the activation and inactivation curves compared with those of normal Wistar rats. In contrast low-voltage-activated (LVA) Ca(2+) channel currents of GRY rats showed no significant changes. These results suggest that functional alteration of Ca(2+) channel currents in cerebellar Purkinje cells of GRY rats is attributed to the change of HVA Ca(2+) channel currents, and that increased HVA Ca(2+) channel function underlies the cerebellar dysfunction and ataxic phenotype of GRY rats. 相似文献
78.
Mana Tomiyama Saki Takayama Hiroko Konno Takeshi Murakoshi Masafumi Koga Momoko Nakamura Yasuhiro Yamashiro Tadashi Matsubayashi 《Pediatric blood & cancer》2023,70(12):e30666
Case 1 presented with severe anemia and received an intrauterine blood cell transfusion at 33 weeks of gestation. The anemia spontaneously improved in early infancy. Case 2, the father of Case 1, had an uneventful birth with no evidence of anemia, though microcytic anemia was observed during childhood. The genetic analysis of the β-globin gene cluster identified a novel heterozygous deletion of DNA extending from the Gγ-globin gene downstream to the β-globin gene, confirming a diagnosis of (GγAγδβ)0-thalassemia. In cases where thalassemia is suspected based on blood tests, a genetic diagnosis should be performed for the sake of the offspring. 相似文献
79.
H. Ishida K. Konno Y. Hamashima T. Komatsuda H. Naganuma Y. Asanuma J. Ishida O. Masamune 《Abdominal imaging》1998,23(4):354-357
Two cases of small bowel (S-B) varices associated with portal hypertension, one with liver cirrhosis and one with portal
thrombus, are reported. Detection of S-B varices has been a challenging task and several invasive diagnostic techniques have
been used for this purpose. However, in our cases, color Doppler sonography revealed the S-B varices supplied by the superior
mesenteric vein and draining to the iliac (one case) or ovarian vein (other case), which helped to establish an early appropriate
diagnostic and treatment plan.
Received: 19 March 1997/Accepted: 14 May 1997 相似文献
80.
Katsutaka Yamada Yoichi Aota Takayuki Higashi Ko Ishida Takanori Nimura Tomoyuki Konno Tomoyuki Saito 《European spine journal》2014,23(3):504-507