全文获取类型
| 收费全文 | 334564篇 |
| 免费 | 11260篇 |
| 国内免费 | 1242篇 |
专业分类
| 耳鼻咽喉 | 3419篇 |
| 儿科学 | 9559篇 |
| 妇产科学 | 6845篇 |
| 基础医学 | 40547篇 |
| 口腔科学 | 4903篇 |
| 临床医学 | 27439篇 |
| 内科学 | 61119篇 |
| 皮肤病学 | 5107篇 |
| 神经病学 | 28358篇 |
| 特种医学 | 16804篇 |
| 外科学 | 50285篇 |
| 综合类 | 4478篇 |
| 现状与发展 | 5篇 |
| 一般理论 | 81篇 |
| 预防医学 | 27466篇 |
| 眼科学 | 7197篇 |
| 药学 | 22447篇 |
| 中国医学 | 2237篇 |
| 肿瘤学 | 28770篇 |
出版年
| 2023年 | 1006篇 |
| 2022年 | 2802篇 |
| 2021年 | 4911篇 |
| 2020年 | 2565篇 |
| 2019年 | 3685篇 |
| 2018年 | 25789篇 |
| 2017年 | 20168篇 |
| 2016年 | 23211篇 |
| 2015年 | 6626篇 |
| 2014年 | 7812篇 |
| 2013年 | 9260篇 |
| 2012年 | 19606篇 |
| 2011年 | 32886篇 |
| 2010年 | 25659篇 |
| 2009年 | 17337篇 |
| 2008年 | 28339篇 |
| 2007年 | 30335篇 |
| 2006年 | 8980篇 |
| 2005年 | 10178篇 |
| 2004年 | 10489篇 |
| 2003年 | 10524篇 |
| 2002年 | 7854篇 |
| 2001年 | 4659篇 |
| 2000年 | 4453篇 |
| 1999年 | 3445篇 |
| 1998年 | 1524篇 |
| 1997年 | 1206篇 |
| 1996年 | 1055篇 |
| 1995年 | 970篇 |
| 1994年 | 851篇 |
| 1993年 | 706篇 |
| 1992年 | 1634篇 |
| 1991年 | 1688篇 |
| 1990年 | 1502篇 |
| 1989年 | 1336篇 |
| 1988年 | 1222篇 |
| 1987年 | 1086篇 |
| 1986年 | 1051篇 |
| 1985年 | 925篇 |
| 1984年 | 678篇 |
| 1983年 | 600篇 |
| 1982年 | 429篇 |
| 1981年 | 381篇 |
| 1980年 | 378篇 |
| 1979年 | 528篇 |
| 1978年 | 417篇 |
| 1977年 | 397篇 |
| 1976年 | 355篇 |
| 1974年 | 380篇 |
| 1973年 | 330篇 |
排序方式： 共有10000条查询结果，搜索用时 15 毫秒
11.
12.
Bo Gyeong Lee Ok Kyung Ham Soo Hyun Kim Eun Jin Lee Hee Sun Kang Duckhee Chae 《Women & health》2020,60(8):887-898
ABSTRACT The present study investigated the concomitants of menopause-specific quality of life among premenopausal and postmenopausal women. Based on the Wilson and Cleary model of quality of life, this cross-sectional study recruited 329 women of age 40–65 years following operational convenience. The study was conducted in the office of the Korea Population, Health and Welfare Association (KPHWA) in Incheon, South Korea. Data collected on sociodemographic characteristics, social support, biological/physiological characteristics, the Pittsburgh Sleep Quality Index (PSQI-K), and self-rated health. Menopause-specific quality of life questionnaire (MENQOL) was used in this study. Hierarchical multiple linear regression analysis was performed. The study found that social support and self-rated health were negatively correlated with MENQOL in premenopausal women, while the income level and self-rated health were negatively associated with MENQOL in postmenopausal women. Sleep quality was positively correlated with MENQOL in both premenopausal and postmenopausal women. The study results indicate the need for tailored approaches based on menopausal status. Especially, social support may help improve the MENQOL of premenopausal women, while in postmenopausal women, improved sleep quality may enhance their menopause-specific quality of life. 相似文献
13.
Hanna Lee Mary K. Tan Andrew T. Yan Paul Angaran Paul Dorian Claudia Bucci Jean C. Gregoire Alan D. Bell Martin S. Green Peter L. Gross Allan Skanes Charles R. Kerr L. Brent Mitchell Jafna L. Cox Vidal Essebag Brett Heilbron Krishnan Ramanathan Carl Fournier Shaun G. Goodman 《The Canadian journal of cardiology》2019,35(2):160-168
Background
Physicians treating nonvalvular atrial fibrillation (AF) assess stroke and bleeding risks when deciding on anticoagulation. The agreement between empirical and physician-estimated risks is unclear. Furthermore, the association between patient and physician sex and anticoagulation decision-making is uncertain.Methods
We pooled data from 2 national primary care physician chart audit databases of patients with AF (Facilitating Review and Education to Optimize Stroke Prevention in Atrial Fibrillation and Coordinated National Network to Engage Physicians in the Care and Treatment of Patients with Atrial Fibrillation Chart Audit) with a combined 1035 physicians (133 female, 902 male) and 10,927 patients (4567 female and 6360 male).Results
Male physicians underestimated stroke risk in female patients and overestimated risk in male patients. Female physicians estimated stroke risk well in female patients but underestimated the risk in male patients. Risk of bleeding was underestimated in all. Despite differences in risk assessment by physician and patient sex, > 90% of patients received anticoagulation across all subgroups. There was modest agreement between physician estimated and calculated (ie, CHADS2 score) stroke risk: Kappa scores were 0.41 (0.35-0.47) for female physicians and 0.34 (0.32-0.36) for male physicians.Conclusions
Our study is the first to examine the association between patient and physician sex influences and stroke and bleeding risk estimation in AF. Although there were differences in agreement between physician estimated stroke risk and calculated CHADS2 scores, these differences were small and unlikely to affect clinical practice; further, despite any perceived differences in the accuracy of risk assessment by sex, most patients received anticoagulation. 相似文献14.
K.-C. Sung D.-C. Seo S.-J. Lee M.-Y. Lee S.H. Wild C.D. Byrne 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2019,29(5):489-495
Background and aims
It is not known whether non alcoholic fatty liver disease (NAFLD) is a risk factor for diabetes in non obese, non centrally-obese subjects. Our aim was to investigate relationships between fatty liver, insulin resistance and a biomarker score for liver fibrosis with incident diabetes at follow up, in subjects who were neither obese nor centrally-obese.Methods and results
As many as 70,303 subjects with a body mass index (BMI) < 25 kg/m2 and without diabetes were followed up for a maximum of 7.9 years. At baseline, fatty liver was identified by liver ultrasound, insulin resistance (IR) by homeostatic model assessment of insulin resistance (HOMA-IR) ≥2.0, and central obesity by waist circumference (waist circumference ≥90 cm (men) and ≥85 cm (women). The Fibrosis-4 (FIB-4 score) was used to estimate extent of liver fibrosis. Cox proportional hazards models adjusted for confounders were used to estimate hazard ratios (aHRs) for incident diabetes. As many as 852 incident cases of diabetes occurred during follow up (median [IQR] 3.71 [2.03] years). Mean ± SD BMI was 22.8 ± 1.8 and 21.7 ± 2.0 kg/m2 in subjects with and without diabetes at follow up. In subjects without central obesity and with fatty liver, aHRs (95% CI) for incident diabetes at follow up were 2.17 (1.56, 3.03) for men, and 2.86 (1.50,5.46) for women. Similar aHRs for incident diabetes occurred with fatty liver, IR and the highest quartile of FIB-4 combined, in men; and there was a non significant trend toward increased risk in women.Conclusions
In normal weight, non-centrally obese subjects NAFLD is an independent risk factor for incident diabetes. 相似文献15.
K.A. Lee M.T.A. Sharabiani D. Tumino J. Wadsley V. Gill G. Gerrard R. Sindhu M.N. Gaze L. Moss K. Newbold 《Clinical oncology (Royal College of Radiologists (Great Britain))》2019,31(6):385-390
Aims
To obtain an overview of the management and outcomes of children aged 18 years or younger diagnosed with differentiated thyroid carcinoma of follicular cell origin across the UK, by collecting and analysing data from the limited number of centres treating these patients. This multicentre data might provide a more realistic perspective than single-institution series.Materials and methods
Six centres submitted data extracted from historical records on patients aged 18 years or younger, diagnosed between 1964 and 2017. The univariate and multivariable Cox proportional hazard model was used to identify potential predictors of progression-free survival, using national data as a control.Results
Data on 166 patients were available for analysis. Females (74%) were predominant, and the age ranged from 3 to 19 years at diagnosis, mean 14.1 years. Nodal metastases were present in 51%; 12% had distant metastases. After surgery, 95% received radioactive iodine (39% on more than one occasion) and 4% received external beam radiotherapy. With a median follow-up duration of 5 years, 69% are alive with no evidence of disease; 20% are alive with a raised thyroglobulin level as the only evidence of residual disease; 6% have residual structural disease detectable on imaging; 2% have died, from cerebral metastases.Conclusion
Despite most patients having advanced disease at presentation, outcomes are very good. A national prospective registry should allow systematic collection of good-quality data and may facilitate research to further improve outcomes. 相似文献16.
17.
18.
19.
20.