全文获取类型
收费全文 | 41201篇 |
免费 | 3539篇 |
国内免费 | 173篇 |
专业分类
耳鼻咽喉 | 374篇 |
儿科学 | 1347篇 |
妇产科学 | 941篇 |
基础医学 | 5865篇 |
口腔科学 | 528篇 |
临床医学 | 4761篇 |
内科学 | 9098篇 |
皮肤病学 | 937篇 |
神经病学 | 4305篇 |
特种医学 | 1144篇 |
外国民族医学 | 1篇 |
外科学 | 5445篇 |
综合类 | 306篇 |
一般理论 | 37篇 |
预防医学 | 3762篇 |
眼科学 | 655篇 |
药学 | 2521篇 |
中国医学 | 104篇 |
肿瘤学 | 2782篇 |
出版年
2023年 | 181篇 |
2022年 | 412篇 |
2021年 | 892篇 |
2020年 | 677篇 |
2019年 | 1140篇 |
2018年 | 1261篇 |
2017年 | 1014篇 |
2016年 | 1038篇 |
2015年 | 1310篇 |
2014年 | 1619篇 |
2013年 | 2183篇 |
2012年 | 2765篇 |
2011年 | 3015篇 |
2010年 | 1861篇 |
2009年 | 1678篇 |
2008年 | 2573篇 |
2007年 | 2653篇 |
2006年 | 2528篇 |
2005年 | 2531篇 |
2004年 | 2365篇 |
2003年 | 2345篇 |
2002年 | 2403篇 |
2001年 | 359篇 |
2000年 | 278篇 |
1999年 | 365篇 |
1998年 | 446篇 |
1997年 | 399篇 |
1996年 | 314篇 |
1995年 | 359篇 |
1994年 | 287篇 |
1993年 | 280篇 |
1992年 | 191篇 |
1991年 | 206篇 |
1990年 | 175篇 |
1989年 | 149篇 |
1988年 | 157篇 |
1987年 | 168篇 |
1986年 | 151篇 |
1985年 | 142篇 |
1984年 | 159篇 |
1983年 | 127篇 |
1982年 | 184篇 |
1981年 | 183篇 |
1980年 | 159篇 |
1979年 | 98篇 |
1978年 | 107篇 |
1977年 | 99篇 |
1976年 | 77篇 |
1975年 | 65篇 |
1972年 | 70篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
Philippe Nickers Luc Coppens Jean de Leval Nicolas Jansen Jean-Marie Deneufbourg 《Radiotherapy and oncology》2006,79(3):329-334
BACKGROUND AND PURPOSE: To evaluate on 201 locally advanced prostatic cancers prospectively treated in a phase II trial, the efficacy of a combination of external beam radiotherapy (39.6 Gy) and (192)Ir low dose rate brachytherapy (Bt) (40-45 Gy). PATIENTS AND METHODS: Sixty-four patients were included in the intermediate prognosis group with only one of the following adverse factors (PSA > 10 ng/ml, Gleason score > or = 7 or clinical stage > or =T2b) and 137 in the unfavourable group when at least two of these factors were present. RESULTS: The actuarial 4 years biochemical no evidence of disease is 82.8% for the entire population. It is, respectively, 97 and 76% in the intermediate and unfavourable prognosis groups (P < 0.0001). Grade > or =3 late urinary complications occurred in 13 patients (6.5%). Eight patients (4%) presented late grade 2 rectal complications but no grades 3-5 was observed. CONCLUSIONS: Even if an alpha/beta of 1.5-3 Gy theoretically favours the use of a high dose rate mode of irradiation, the early results presented here are as good as those reported for similar groups of patients with high dose rate treatments. Late toxicity is identical but our urinary toxicity is within the less favourable and rectal toxicity within the most favourable results. We can postulate that while inducing very high hyperdosage regions (V150) mainly focused on the peripheral zone, most of the Bt techniques consist of a more ablative treatment. Many of the radiobiological studies on Bt did not in fact take into account the heterogeneity of irradiation inside the CTV. This study highlights the need to explore pulsed dose rate therapies, permanent implant and new available radioisotopes such as (169)Ytterbium that will offer the safety of low and lower dose rates. The actual late toxicity of the different Bt techniques is not yet inexistent indeed. 相似文献
12.
Kathleen Pierson Donald Addington Jean Addington Scott Patten 《Revue canadienne de psychiatrie》2006,51(11):715-718
OBJECTIVE: To assess whether pharmacokinetic drug interactions occur when sertraline is added to antipsychotic medications. METHOD: Forty-eight patients with remitted DSM-IV schizophrenia and comorbid major depression were randomized to placebo for 6 weeks or sertraline 50 mg for 4 weeks followed by sertraline 50 mg to 100 mg for 2 weeks for nonresponders. Treatment with the patients' usual antipsychotic continued. Weekly clinical outcome assessments occurred for 6 weeks, and serum samples for drug monitoring were collected at Weeks 1, 5, and 6. Serum concentrations of sertraline and antipsychotics were measured with standard assays. RESULTS: In both placebo- and sertraline-treated groups, most patients displayed minor fluctuations in antipsychotic serum levels over 6 weeks. There was no clinical evidence of drug interactions in the sertraline-treated group. CONCLUSIONS: Clinically significant adverse effects did not occur despite variable antipsychotic serum levels with or without sertraline. Concern about pharmacokinetic interactions should not deter the use of sertraline for depression in individuals with schizophrenia. 相似文献
13.
Regina Gershkovich David Sacks Abraham Chlibovsky Sonia Yudaev Asher Korzets 《Nephrology, dialysis, transplantation》2006,21(2):539-540
Case report A 28-year-old female patient was admitted because of painlessmacroscopic haematuria. Past history included severe mentalretardation and nystagmus. At age 17, a computed tomography(CT) scan of the brain showed an absent cerebellar vermis andcerebellar hypoplasia. There was no 相似文献
14.
15.
To examine the prevalence of Internet sex networking among men who have sex with men (MSM) in Hong Kong and risk behaviors associated with the behavior, a telephone survey of 15,230 Hong Kong Chinese men aged 18-60 was conducted. Of the 283 active MSM (having engaged in some MSM behaviors in the last 6 months) identified, 17.7% had networked for MSM partners via the Internet in the last 6 months. Younger age (odds ratio [OR] for age < or = 25 vs. age >25 = 4.67, 95% confidence interval [CI] = 2.35-9.28) and being an anal-sex MSM (OR = 4.72, 95% CI=2.36-9.44) were independent predictors of Internet sex networking. Being an Internet sex networker was associated with some risk behaviors such as having contracted a sexually transmitted disease (adjusted OR = 4.79, 95% CI = 1.34-17.11), having had > or = 3 MSM partners (adjusted OR = 4.74, 95% CI = 2.20-10.23), and having engaged in anal sex (adjusted OR = 3.95, 95% CI = 1.89-8.23). HIV prevention programs for MSM should thereby include Internet-based interventions. 相似文献
16.
17.
18.
19.
Jean Marie Jully Marie Christine Béné Gérard Martin Gilbert Faure 《Journal of clinical periodontology》1986,13(3):223-227
The cellular infiltrate present in human diseased gingiva was analyzed in biopsies from 12 patients with gingivitis or periodontitis. The samples studied had been obtained in the course of surgery at inflammatory sites remaining after institution of periodontal treatment. Histological and immunological techniques were used to identify macrophages, B-cells, plasma-cells, T-cells and T cell subsets, as well as cells expressing class II HLA membrane antigens. T-cells appeared as the predominant population, but plasma-cells were also visualized in nearly all samples. Both OKT4+ and OKT8+ cells were seen in all cases, the latter being more numerous in periodontitis patients. Interdigitating-like cells were observed, positively labelled for class II antigens, as well as macrophages which were more numerous in periodontitis patients. These results suggest the participation of all components of the immune response in gingival disease, in a way resembling chronic recurrent inflammatory diseases. 相似文献
20.
As the biological width is established around neighboring implants, there is a flattening of the interimplant bone and a change in the position of the soft tissue. As a result, a normal progression of papilla from natural teeth through the adjacent implant area is lost. This presentation describes various techniques and strategies to improve the aesthetic outcome of anterior implant restorations, together with the use of a scalloped implant designed to sustain the interdental bony peaks, and in doing so, maintain the interimplant papillae. 相似文献