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21.
de Gonzalo-Calvo D Fernández-García B de Luxán-Delgado B Rodríguez-González S García-Macia M Suárez FM Solano JJ Rodríguez-Colunga MJ Coto-Montes A 《Age (Dordrecht, Netherlands)》2012,34(3):761-771
The objective of the present study was to investigate the changes in a large panel of emergent geriatric biomarkers in long-term
trained elderly men to analyze the effects of long-term exercise on an aged population. We collected blood samples from two
groups of male volunteers older than 65 years who maintain a measure of functional independence: one group of sedentary subjects
without a history of regular physical activity and the other of subjects who have sustained training, starting during adulthood
(mean training time = 49 ± 8 years). We studied morbidity, polypharmacy, cellular and serological inflammatory parameters,
and endocrine mediators. After adjusting for confounding factors, we observed reduced medication intake per subject and lower
number of diseases per subject with statistical differences nearly significant in the long-term exercise group. We showed
that long-term training was associated with lower levels of white blood cell counts, neutrophil counts, interleukin-6, interleukin-10,
interleukin-1 receptor antagonist, and soluble TNF receptor-I. Furthermore, we noted an increase in the concentrations of
insulin-like growth factor-1 and dehydroepiandrosterone in the long-term training group. We concluded that long-term exercise
training from adulthood to old age is clearly associated with a healthy profile of emergent geriatric biomarkers. Long-term
training could improve the inflammatory–endocrine imbalance associated with disease, frailty, functional decline, and mortality
in elderly men. Our results point to the benefits of prolonged exercise from adulthood to old age. 相似文献
22.
Sanz J Boluda JC Martín C González M Ferrá C Serrano D de Heredia CD Barrenetxea C Martinez AM Solano C Sanz MA Sanz GF 《Bone marrow transplantation》2012,47(10):1287-1293
Attempts to optimize outcomes in cord blood transplantation (CBT) by using new conditioning regimens and standardization of cord blood unit selection are warranted. In all, 88 patients (18 children and 70 adults) with hematological malignancy from nine Spanish institutions underwent a single-unit CBT after an i.v. BU-based myeloablative conditioning regimen. All evaluable patients except one engrafted. The overall cumulative incidence (CI) of myeloid engraftment was 94% at a median time of 19 days. In multivariate analysis, nonadvanced disease stage was the only factor with a favorable impact on myeloid engraftment. The CI of acute GVHD grades II-IV and chronic extensive GVHD were 24% each. The CI of nonrelapse mortality at 100 days, 180 days and 5 years was 14, 23 and 44%, respectively. The 5-year CI of relapse was 18%, whereas disease-free survival (DFS) was 46%, 39% and 11% for patients transplanted in early, intermediate and advanced stages of the disease, respectively. Our study shows high rates of engraftment with fast neutrophil recovery in patients undergoing single-unit CBT using a BU-based conditioning regimen. Long-term DFS can be achieved in a substantial number of patients with high-risk hematological malignancies, particularly when transplanted in an early stage of the disease. 相似文献
23.
Jae-Young Hong Seung-Woo Suh Easwar TR Suk Joo Hong Yong-Chul Yoon Hyung-Jin Kang 《The spine journal》2013,13(11):1510-1520
Background contextFew accurate analyses of clinically useful vertebral anatomy have been conducted, and most have focused on thoracic idiopathic scoliosis.PurposeTo evaluate the different anatomic characteristics in scoliosis by disease type and level.Study designObservational cohort study.Patient sampleForty-eight patients with scoliosis were included in this study.Outcome measuresSubjects underwent computed tomography (CT) of the whole spine.MethodsForty-eight patients with scoliosis were included in this study: 15 adolescent idiopathic, 11 cerebral palsy (CP), 10 muscular dystrophy (MD), and 12 congenital (CG) scoliosis patients with similar demographics. Subjects underwent CT of the whole spine, preoperatively. Eight anatomic parameters were measured in multiplanar reconstructive CT images, and statistical analysis was performed to investigate differences.ResultsIn general, values in the anatomic parameters were similar for the four diseases. Each parameter showed the unique change pattern according to the spinal level regardless of curvature shape, direction, or magnitude. In particular, chord length (CL) in MD and CG scoliosis was lower than in adolescent idiopathic scoliosis (AIS) and CP, and pedicle rib unit length was lower in CG scoliosis than in the other diseases (p<.05). Comparisons of convex and concave anatomies in AIS showed that inner pedicle width (PWI) and outer pedicle width (PWO) were wider for convex side, CL, pedicle width, and transverse pedicle angle were greater for concave side (p<.05), and differences were more significant at apices. However, in CP, PWI and PWO were similar between convex and concaves sides (p>.05). Although PWI and PWO were wider for convex sides and CL and pedicle length were greater for concave sides in MD (p<.05), differences were less significant at apices. Particularly, CG scoliosis showed severely deformed anatomy, with differences of seven parameters at apical vertebrae (p<.05).ConclusionClinical anatomies of vertebrae in scoliosis were found to differ significantly at different levels and in terms of convexity and disease type. 相似文献
24.
Effectiveness of a red cell antigen‐matching transfusion protocol in sickle cell disease patients 下载免费PDF全文
25.
Solano L Pepe L Donati V Persichetti S Laudani G Colaci A 《Journal of clinical psychology》2007,63(4):357-369
The aim of this study was to assess the effects of the writing technique on postoperative course in interaction with different levels of risk. Participants were 40 urologic inpatients waiting to undergo transurethral resection of the prostate, with different levels of surgical risk as assessed with the Goldman Preoperative Risk Index (L. Goldman et al., 1978). Only 20 participants wrote for 3 days about the experience of being in the hospital. Measures were days of stay in the hospital after the operation, the Symptom Check List (SCL-90; L. R. Derogatis, 1977; Italian version: G. Magni, C. Messina, D. De Leo, A. Mosconi, & M. Carli, 1983) scores, and a medical evaluation of postoperative course. A significant positive effect of writing on all three dependent variables emerged only in low-risk participants. High-risk writing participants showed a nonsignificantly worse postoperative course on all parameters than did high-risk nonwriting participants. In highly stressful conditions, writing therefore should be employed only with caution. 相似文献
26.
Courtin F Jamonneau V Duvallet G Garcia A Coulibaly B Doumenge JP Cuny G Solano P 《Tropical medicine & international health : TM & IH》2008,13(3):334-344
Objective To review the geography and history of sleeping sickness (Human African trypanosomiasis; HAT) over the past 100 years in West Africa, to identify priority areas for sleeping sickness surveillance and areas where HAT no longer seems active. Method History and geography of HAT were summarized based on a review of old reports and recent publications and on recent results obtained from medical surveys conducted in West Africa up to 2006. Results/conclusions Active HAT foci seem to have moved from the North to the South. Endemic HAT presently appears to be limited to areas where annual rainfall exceeds 1200 mm, although the reasons for this remain unknown. There has also been a shift towards the south of the isohyets and of the northern distribution limit of tsetse. Currently, the most severely affected countries are Guinea and Ivory Coast, whereas the northern countries seem less affected. However, many parts of West Africa still lack information on HAT and remain to be investigated. Of particular interest are the consequences of the recent political crisis in Ivory Coast and the resulting massive population movements, given the possible consequences on HAT in neighbouring countries. 相似文献
27.
Caballero Beatriz Rubio-González Adrián Potes Yaiza Martínez-Reig Marta Sánchez-Jurado Pedro Manuel Romero Luis Solano Juan José Abizanda Pedro Coto-Montes Ana 《Age (Dordrecht, Netherlands)》2014,36(2):851-867
GeroScience - Herein we considered the role of oxidative stress on deficiencies of functional physical performance that could affect a future pre-frailty condition. Using principal component... 相似文献
28.
Sharat Damodar Prashantha Bhat Praveen Kumar Rajesh TR Ratan Gupta 《Indian journal of hematology & blood transfusion》2014,30(1):64-67
Acute leukemia, secondary myelodysplasia and paroxysmal nocturnal hemoglobinuria evolving from severe aplastic anemia (AA) following immunosuppressive therapy are well recognized. However, severe AA occurring after complete remission of acute promyelocytic leukemia (APL) has been documented only once in 2009. We report a case of 30-year-old male diagnosed with APL who achieved complete cytogenetic remission with all-trans retinoic acid based induction regimen and developed severe AA few months later during maintenance therapy. 相似文献
29.
30.
Effect of the IL28B Rs12979860 C/T polymorphism on the incidence and features of active cytomegalovirus infection in allogeneic stem cell transplant patients 下载免费PDF全文