全文获取类型
收费全文 | 281篇 |
免费 | 32篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 24篇 |
妇产科学 | 2篇 |
基础医学 | 44篇 |
口腔科学 | 1篇 |
临床医学 | 21篇 |
内科学 | 82篇 |
皮肤病学 | 21篇 |
神经病学 | 24篇 |
特种医学 | 1篇 |
外科学 | 37篇 |
综合类 | 6篇 |
预防医学 | 18篇 |
眼科学 | 2篇 |
药学 | 15篇 |
肿瘤学 | 6篇 |
出版年
2023年 | 2篇 |
2022年 | 4篇 |
2021年 | 7篇 |
2020年 | 4篇 |
2019年 | 10篇 |
2018年 | 11篇 |
2017年 | 8篇 |
2016年 | 6篇 |
2015年 | 2篇 |
2014年 | 10篇 |
2013年 | 9篇 |
2012年 | 21篇 |
2011年 | 14篇 |
2010年 | 16篇 |
2009年 | 5篇 |
2008年 | 11篇 |
2007年 | 7篇 |
2006年 | 15篇 |
2005年 | 18篇 |
2004年 | 14篇 |
2003年 | 5篇 |
2002年 | 6篇 |
2001年 | 6篇 |
2000年 | 9篇 |
1999年 | 9篇 |
1998年 | 3篇 |
1997年 | 2篇 |
1995年 | 4篇 |
1994年 | 2篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 4篇 |
1989年 | 7篇 |
1988年 | 7篇 |
1987年 | 3篇 |
1986年 | 3篇 |
1984年 | 8篇 |
1982年 | 5篇 |
1981年 | 5篇 |
1980年 | 3篇 |
1979年 | 2篇 |
1977年 | 2篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1972年 | 2篇 |
1970年 | 1篇 |
1969年 | 3篇 |
1968年 | 2篇 |
1967年 | 4篇 |
1966年 | 1篇 |
排序方式: 共有313条查询结果,搜索用时 15 毫秒
81.
Mooney JA Helms PJ Jolliffe IT Smail P;Scottish Study Group for the Care of Diabetes in the Young 《Archives of disease in childhood》2004,89(10):970-973
Background: Diagnoses of type 1 insulin dependent diabetes mellitus are generally more common in winter, although this seasonal pattern has not been observed in children of preschool age (0–4 years) or in all countries. Aims: To confirm the persistence of seasonality and the influence of age, holidays, and weekends. Methods: We extracted data on date of birth, date of presentation, age, and sex of children diagnosed with diabetes and registered with the Scottish Study Group for the Care of Diabetes in the Young. Cosinor analysis was applied to monthly and mid-monthly data. Two sample Z tests were used to compare the epochs 1984–1992 and 1993–2001. Results: Some 4517 children between 0 and 14 years of age (2407 male and 2110 female) presented with IDDM between 1 January 1984 and 31 December 2001. Seasonality was evident in children above 4 years of age with amplitudes of 19.5–25.7% and peaks between mid December and mid January. Presentation was strongly influenced by weekends and holiday periods, with reduced presentations in December compared with November and January, and with the lowest presentations in July (the main Scottish holiday month). Using mid-month to mid-month data did not change the overall seasonality but did improve the fits for cosinor analysis. Mondays and Fridays were the most common days for presentation. Conclusion: Initial presentation of IDDM in Scotland follows a stable seasonal pattern in all but the youngest children with lower rates of presentation in holiday periods and at weekends for all age groups. 相似文献
82.
Minville V Pianezza A Asehnoune K Cabardis S Smail N 《European journal of anaesthesiology》2006,23(7):594-597
BACKGROUND AND OBJECTIVE: Out-of-hospital intravenous line placement is used daily. All available studies take place using paramedics, e.g. US-American emergency medical system. The aim of this study was to assess the intravenous line placement feasibility (time and success rate) in the French emergency medical system. METHODS: A prospective observational study was performed by a French out-of-hospital team during 3-month assessing the timing and success rates for intravenous line placement. All patients were enrolled at the emergency medical service of a university hospital in France. Six hundred and sixty-nine consecutive patients were included, 388 (58%) had at least one intravenous line placement in the out-of-hospital setting. RESULTS: Success rate was 76% at the first attempt and 98% at the second attempt. The overall success rate for intravenous line placement was 99.7% (only one failure), and the average successful intravenous line time was 4.4+/-2.8 min. Attempts ranged from 1 to 8. The time for intravenous line placement with blood sampling (58% of patients) is statistically longer than without (4.6+/-2.5 vs. 4.3+/-3 min, P<0.05). Seventeen of the enrolled patients were trauma patients, and 83% were non-trauma patients. Four hundred and twenty-seven intravenous lines were placed, intravenous 10% had more than one intravenous line. Seventy-one percent of the intravenous lines were used to infuse drugs, the others were security intravenous. No significant difference was noticed between trauma and non-trauma patients in regard to the success rate and the time to place the intravenous line. CONCLUSION: The out-of-hospital team was skilled at intravenous line placement (success rate=99.7%), and the time required to performed intravenous line access was short. 相似文献
83.
84.
The photosensitivity of freshly dissociated R3230AC mammary adenocarcinoma cells was examined by measurement of the activities of selected intracellular enzymes after treatment with hematoporphyrin derivative (Hpd) and exposure to light in vitro. Enzymes selected as representative of the cytosolic cell compartment showed no loss in activity, whereas malate dehydrogenase, located in the mitochondrial matrix, displayed a modest decrease (approximately 15%) in activity. In contrast, cytochrome c oxidase and succinate dehydrogenase, enzymes associated with the mitochondrial membrane, demonstrated a very rapid and more marked inhibition of activities, approximately 45% and 25%, respectively. The time-course of inhibition of these mitochondrial membrane enzymes preceded the loss of cell viability, which displayed slower kinetics as seen by a more gradual and progressive pattern of loss in viability. These data suggest that the mitochondria are an early-affected and important intracellular site for Hpd photosensitization. 相似文献
85.
86.
87.
88.
89.
90.
Vladutiu GD Quackenbush EJ Hainline BE Albers S Smail DS Bennett MJ 《The Journal of pediatrics》2002,141(5):734-736
We describe a lethal neonatal form of carnitine palmitoyltransferase II (CPT II) deficiency with compound heterozygosity for 2 truncation mutations (Q413fs and 109AGC --> GCAGC). A new phenotype for a severe late infantile form of CPT II deficiency with hypoglycemia is associated with compound heterozygosity for the severe Q413fs mutation and a mild point mutation (P50H). 相似文献