全文获取类型
收费全文 | 1527篇 |
免费 | 57篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 40篇 |
妇产科学 | 21篇 |
基础医学 | 228篇 |
口腔科学 | 12篇 |
临床医学 | 93篇 |
内科学 | 209篇 |
皮肤病学 | 26篇 |
神经病学 | 92篇 |
特种医学 | 52篇 |
外科学 | 391篇 |
综合类 | 17篇 |
预防医学 | 281篇 |
眼科学 | 20篇 |
药学 | 41篇 |
肿瘤学 | 52篇 |
出版年
2023年 | 10篇 |
2022年 | 20篇 |
2021年 | 39篇 |
2020年 | 19篇 |
2019年 | 26篇 |
2018年 | 32篇 |
2017年 | 25篇 |
2016年 | 22篇 |
2015年 | 21篇 |
2014年 | 41篇 |
2013年 | 70篇 |
2012年 | 102篇 |
2011年 | 113篇 |
2010年 | 62篇 |
2009年 | 51篇 |
2008年 | 81篇 |
2007年 | 101篇 |
2006年 | 108篇 |
2005年 | 89篇 |
2004年 | 75篇 |
2003年 | 75篇 |
2002年 | 78篇 |
2001年 | 43篇 |
2000年 | 35篇 |
1999年 | 37篇 |
1998年 | 10篇 |
1996年 | 5篇 |
1995年 | 4篇 |
1994年 | 10篇 |
1992年 | 11篇 |
1991年 | 5篇 |
1990年 | 15篇 |
1989年 | 16篇 |
1988年 | 13篇 |
1987年 | 17篇 |
1986年 | 13篇 |
1985年 | 13篇 |
1984年 | 4篇 |
1983年 | 6篇 |
1982年 | 4篇 |
1979年 | 7篇 |
1974年 | 6篇 |
1973年 | 5篇 |
1972年 | 7篇 |
1971年 | 10篇 |
1970年 | 3篇 |
1969年 | 3篇 |
1968年 | 3篇 |
1967年 | 3篇 |
1965年 | 3篇 |
排序方式: 共有1588条查询结果,搜索用时 46 毫秒
151.
The incidence of phlebitis with intravenous amiodarone at guideline dose recommendations 总被引:1,自引:0,他引:1
Postoperative atrial fibrillation following cardiothoracic surgery is common and frequently managed with intravenous (IV) amiodarone. Phlebitis is the most common complication with peripheral infusion of this agent. Current practice guidelines for peripheral IV administration of <2 mg/mL amiodarone were established to reduce the risk of phlebitis. The present study examines the incidence of phlebitis in a postoperative patient population given current dose recommendations. A total of 273 patient charts were reviewed. The incidence of phlebitis in patients given IV amiodarone (n = 36) was 13.9% (95% confidence interval, 2.6-25.2%; p = 0.001). Logistic regression analysis with backward elimination of other therapeutic risk factors suggests that the odds ratio for phlebitis using current dose regimens without IV filters is 19-fold greater than baseline risk in this population. Phlebitis remains a significant complication associated with peripheral infusion of amiodarone within recommended dosing limits. 相似文献
152.
Cuff S DiRusso S Sullivan T Risucci D Nealon P Haider A Slim M 《The Journal of trauma》2007,63(1):172-7; discussion 177-8
153.
154.
Léonard?Fourn Slim?Haddad Pierre?Fournier Roméo?Gansey 《BMC international health and human rights》2009,9(Z1):S14
Background
Despite the efforts of health authorities, vaccination coverage of targeted child populations is still poor in many regions. Parents' reticence has been identified as one cause of this situation. However, there is little data to explain the phenomenon that could support decision-making.Objective
The objective of the study was to uncover the determinants of this reticence toward vaccination among the religious population of the cities of Parakou and Cotonou in Benin.Methods
This was an exploratory study using a qualitative survey of 12 pastors and 30 faithful from churches that are vaccination-reticent and a control group of the same number of faithful belonging to other churches, all Christian. Individual and group interviews were carried out in the local language using a pre-established and pre-tested guide. The data collected underwent discourse content analysis focused on specific themes.Results
Analysis of the data reveals an erroneous perception of child vaccination. Those who are reticent say vaccination goes against the will of God, that it is a poison from the "white witch doctor", and that those who vaccinate their children are committing a sin. Members of the control group argued against this, but without conviction. They adhere to the principle of obedience to authority, a biblical precept invoked when the vaccinators oblige them to vaccinate their children. Other factors were identified that could explain the reticence, such as the tactlessness of the vaccinators, parents' previous experiences and false rumours about vaccination.Conclusion
The reasons for reticence are mainly related to parents' beliefs in religious principles that are sometimes poorly understood. To limit the spread of this phenomenon, more detailed information and negotiation between the health authorities and the pastors of these churches are essential.Abstract in French
See the full article online for a translation of this abstract in French.155.
Anthony S. Ham Marilyn R. Cost Alexandra B. Sassi Charlene S. Dezzutti Lisa Cencia Rohan 《Pharmaceutical research》2009,26(3):502-511
Purpose Nanoparticles formulated from the biodegradable co-polymer poly(lactic-co-glycolic acid) (PLGA), were investigated as a drug
delivery system to enhance tissue uptake, permeation, and targeting for PSC-RANTES anti-HIV-1 activity.
Materials and Methods PSC-RANTES nanoparticles formulated via a double emulsion process and characterized in both in vitro and ex vivo systems to determine PSC-RANTES release rate, nanoparticle tissue permeation, and anti-HIV bioactivity.
Results Spherical, monodisperse (PDI = 0.098 ± 0.054) PSC-RANTES nanoparticles (d = 256.58 ± 19.57 nm) with an encapsulation efficiency of 82.23 ± 8.35% were manufactured. In vitro release studies demonstrated a controlled release profile of PSC-RANTES (71.48 ± 5.25% release). PSC-RANTES nanoparticle
maintained comparable anti-HIV activity with unformulated PSC-RANTES in a HeLa cell-based system with an IC50 of approximately 1pM. In an ex vivo cervical tissue model, PSC-RANTES nanoparticles displayed a fivefold increase in tissue uptake, enhanced tissue permeation,
and significant localization at the basal layers of the epithelium over unformulated PSC-RANTES.
Conclusions These results indicate that PSC-RANTES can readily be encapsulated into a PLGA nanoparticle drug delivery system, retain its
anti-HIV-1 activity, and deliver PSC-RANTES to the target tissue. This is crucial for the success of this drug candidate as
a topical microbicide product. 相似文献
156.
Bearden CE Soares JC Klunder AD Nicoletti M Dierschke N Hayashi KM Narr KL Brambilla P Sassi RB Axelson D Ryan N Birmaher B Thompson PM 《Journal of the American Academy of Child and Adolescent Psychiatry》2008,47(5):515-525
ObjectiveEarly-onset bipolar disorder is thought to be a particularly severe variant of the illness. Continuity with the adult form of illness remains unresolved, but preliminary evidence suggests similar biological underpinnings. Recently, we observed localized hippocampal decreases in unmedicated adults with bipolar disorder that were not detectable with conventional volumetric measures. Using the same three-dimensional mapping methods, we sought to investigate whether a similar pattern exists in adolescents with bipolar disorder.MethodHigh-resolution brain magnetic resonance images were acquired from 16 adolescents meeting DSM-IV criteria for bipolar disorder (mean age 15.5 ± 3.4 years, 50% female) and 20 demographically matched, typically developing control subjects. Three-dimensional parametric mesh models of the hippocampus were created from manual tracings of the hippocampal formation.ResultsControlling for total brain volume, total hippocampal volume was significantly smaller in adolescent patients with bipolar disorder relative to controls (by 9.2%). Statistical mapping results, confirmed by permutation testing, revealed significant localized deformations in the head and tail of the left hippocampus in adolescents with bipolar disorder, relative to normal controls. In addition, there was a significant positive correlation between hippocampal size and age in patients with bipolar disorder, whereas healthy controls showed an inverse relation.DiscussionLocalized hippocampal deficits in adolescent patients with bipolar disorder suggest a possible neural correlate for memory deficits observed in this illness. Moreover, age-related increases in hippocampal size in patients with bipolar disorder, not observed in healthy controls, may reflect abnormal developmental mechanisms in bipolar disorder. This possibility must be confirmed by longitudinal studies. 相似文献
157.
158.
Cioni G Lodesani M Pascale R Coluccini M Sassi S Paolicelli PB Perazza S Ferrari A 《European journal of physical and rehabilitation medicine》2008,44(2):203-211
Recent proposals of classification for cerebral palsy (CP), mainly revised for epidemiological purposes, suggest to abandon the use of the term diplegia. Conversely, in this paper data are presented to support the proposal to maintain the distinction between spastic tetraplegia and diplegia, and to subdivide this latter according to four main clinical patterns of walking observable in these children. This proposal of classification was validated by testing a group of 467 subjects with CP, of whom 213 with diplegia and 115 with tetraplegia, consecutively admitted between January 2005 and December 2006 to two national reference centers for this disability. The results were compared with findings obtained by other methods of classifying gross and fine motor function and associated disorders. The subjects with tetraplegia strongly differ from those of diplegia, both for motor functions and for other disabilities. The four main walking patterns of spastic diplegia were easily recognizable and observers were able to assign most of the subjects to one form of the classification. Significant correlations between walking forms of diplegia and distribution of Gross Motor Function Classification System (GMFCS) levels were found. Some of the forms significantly differ also for fine motor and mental disability. These findings suggest that in clinical practice the category of diplegia not only can be kept as a separate form of CP, but it may be enhanced, through the identification of different subcategories of children, divided according to their walking patterns. 相似文献
159.
Ceravolo R Borghetti D Kiferle L Tognoni G Giorgetti A Neglia D Sassi N Frosini D Rossi C Petrozzi L Siciliano G Murri L 《Brain research bulletin》2008,76(1-2):80-84
One major goal of drug development would be the establishment of biomarkers as objective indicators of normal biological and pathogenetic processes, or pharmacological response to a therapeutic intervention. A potential approach is to investigate proteins in CSF linked to key neuropathological features of Alzheimer's disease (AD). Recently CSF phosphorylated-Tau (p-Tau) levels have been reported to reflect neurofibrillary changes within the brain of patients with AD, however the use of serial CSF investigations in order to monitor the disease progression is not applicable. PET with FDG reveals characteristic patterns in AD patients, however so far no correlation between in vivo metabolic information and pathological features has been reported.
In the present study, we tested whether CSF Tau levels correlate with metabolic rate for glucose consumption in a cohort of 28 AD patients. We found a statistically significative correlation between both CSF total and p-TAU protein and relative metabolic indexes obtained from 18FDG-PET scans in parietal, temporal and occipital lobes bilaterally. These results indicate the existence of a correlation between impairment of cerebral metabolism, estimated throughout FDG-PET, and CSF Tau protein levels. 相似文献
160.
This evidence-based review of the literature aims to answer two questions regarding inguinal hernia repair: 1. should a prosthetic patch be used routinely? 2. Which approach is better - laparoscopic or open surgery? After a comprehensive search of electronic databases we retained only meta-analyses (n=14) and/or randomised clinical trials (n=4). Review of this literature suggests with a good level of evidence that prosthetic hernia repair is the gold standard; the laparoscopic approach has very few proven benefits and may involve more serious complications when performed outside expert centers. The role of laparoscopy for the repair of bilateral or recurrent hernias needs better evaluation. 相似文献