全文获取类型
收费全文 | 2630篇 |
免费 | 135篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 41篇 |
儿科学 | 241篇 |
妇产科学 | 69篇 |
基础医学 | 252篇 |
口腔科学 | 55篇 |
临床医学 | 132篇 |
内科学 | 411篇 |
皮肤病学 | 57篇 |
神经病学 | 191篇 |
特种医学 | 84篇 |
外科学 | 391篇 |
综合类 | 323篇 |
现状与发展 | 1篇 |
一般理论 | 1篇 |
预防医学 | 96篇 |
眼科学 | 40篇 |
药学 | 167篇 |
1篇 | |
中国医学 | 6篇 |
肿瘤学 | 211篇 |
出版年
2022年 | 27篇 |
2021年 | 57篇 |
2020年 | 28篇 |
2019年 | 35篇 |
2018年 | 53篇 |
2017年 | 36篇 |
2016年 | 48篇 |
2015年 | 71篇 |
2014年 | 68篇 |
2013年 | 87篇 |
2012年 | 122篇 |
2011年 | 138篇 |
2010年 | 139篇 |
2009年 | 116篇 |
2008年 | 138篇 |
2007年 | 154篇 |
2006年 | 135篇 |
2005年 | 133篇 |
2004年 | 115篇 |
2003年 | 91篇 |
2002年 | 81篇 |
2001年 | 78篇 |
2000年 | 68篇 |
1999年 | 65篇 |
1998年 | 45篇 |
1997年 | 51篇 |
1996年 | 41篇 |
1995年 | 28篇 |
1994年 | 28篇 |
1993年 | 12篇 |
1992年 | 38篇 |
1991年 | 30篇 |
1990年 | 25篇 |
1989年 | 22篇 |
1988年 | 34篇 |
1987年 | 21篇 |
1986年 | 20篇 |
1985年 | 22篇 |
1984年 | 15篇 |
1983年 | 17篇 |
1982年 | 20篇 |
1981年 | 14篇 |
1978年 | 24篇 |
1977年 | 23篇 |
1976年 | 16篇 |
1975年 | 11篇 |
1974年 | 21篇 |
1973年 | 15篇 |
1972年 | 16篇 |
1970年 | 12篇 |
排序方式: 共有2770条查询结果,搜索用时 15 毫秒
51.
Surinder K. Singhal Naresh K. Panda S. B. S. Mann Ashim Dass 《Indian journal of otolaryngology and head and neck surgery》1997,49(3):265-268
Basaloid squamous cell carcinoma is a rare variant of squamous cell carcinoma, Larynx has been an uncommon site of this tumour
which is said to have aggressive biological behaviour with high incidence of cervical and distant metastasis along with second
primary. Two cases of laryngeal basaloid squamous cell carcinoma are reported with relevant review of literature. The submucosal
spread of tumour is highlighted alongwith role of preoperative radio therapy. 相似文献
52.
Dibenzo[a,l]pyrene-induced DNA adduction, tumorigenicity, and Ki-ras oncogene mutations in strain A/J mouse lung 总被引:1,自引:0,他引:1
Prahalad AK; Ross JA; Nelson GB; Roop BC; King LC; Nesnow S; Mass MJ 《Carcinogenesis》1997,18(10):1955-1963
Dibenzo[a,l]pyrene (DB[a,l]P), an environmental polycyclic aromatic
hydrocarbon, is the most potent carcinogen ever tested in mouse skin and
rat mammary gland. In this study, DB[a,l]P was examined for DNA adduction,
tumorigenicity, and induction of Ki-ras oncogene mutations in tumor DNA in
strain A/J mouse lung. Groups of mice received a single i.p. injection of
0.3, 1.5, 3.0, or 6.0 mg/kg DB[a,l]P in tricaprylin. Following treatment,
DNA adducts were measured at times between 1 and 28 days, while tumors were
counted at 250 days and analyzed for the occurrence of point mutations in
codons 12 and 61 of the Ki-ras oncogene. DB[a,l]P in strain A/J mouse lung
induced six major and four minor DNA adducts. Maximal levels of adduction
occurred between 5 and 10 days after injection followed by a gradual
decrease. DB[a,l]P-DNA adducts in lung tissue were derived from both anti-
and syn-11,12- dihydroxy-13,14-epoxy-
11,12,13,14-tetrahydrodibenzo[a,l]pyrene (DB[a,l]PDE) and both
deoxyadenosine (dAdo) and deoxyguanosine (dGuo) residues in DNA as revealed
by cochromatography. The major adduct was identified as a product of the
reaction of an anti-DB[a,l]PDE with dAdo in DNA. DB[a,l]P induced
significant numbers of lung adenomas in a dose- dependent manner, with the
highest dose (6.0 mg/kg) yielding 16.1 adenomas/mouse. In
tricaprylin-treated control animals, there were 0.67 adenomas/mouse. Based
on the administered dose, DB[a,l]P was more active than other environmental
carcinogens including benzo[a]pyrene. As a function of time-integrated DNA
adduct levels, DB[a,l]P induced lung adenomas with about the same potency
as other PAHs, suggesting that the adducts formed by DB[a,l]P are similar
in carcinogenic potency to other PAHs in the strain A/J mouse lung model.
Analysis of the Ki- ras mutation spectrum in DB[a,l]P-induced lung tumors
revealed the predominant mutations to be G-->T transversions in the
first base of codon 12, A-->G transitions in the second base of codon
12, and A-->T transversions in the second or third base of codon 61,
concordant with the DNA adduct profile.
相似文献
53.
Twenty-seven patients with idiopathic palmoplanter hyperhidrosis were treated with Iontotherapy over a one year period. In twenty-four cases there was a good response but maintenance therapy was required every 3-4 weeks.KEY WORDS: Iontophoresis, Palmoplanter hyperhidrosis 相似文献
54.
55.
Surinder K. Singhal Ramandeep S. Virk Arjun Dass Bimaljit Singh Sandhu 《Indian journal of otolaryngology and head and neck surgery》2006,58(3):300-302
Tracheoesophageal fistula is a life threatening condition. Patients not managed surgically ultimately die of their disease.
Surgical management is the treatment of choice. We present a case of a patient that developed a tracheoesophageal fistula
after tracheostomy. Surgical repair was done which failed due to infection. The patient was managed with the help of an esophageal
stent and Trichloroacetic Acid cautery. This approach can be used in selected patients, depending upon the size and site of
TEE Larger fistulae and those situated lower down e.g. supra carinal cannot be managed by this technique. 相似文献
56.
57.
Naveen Kumar AK Gadpayle Deepshikha Trisal 《Asian Pacific journal of tropical medicine》2013,6(10):839-840
In last decade, dengue has emerged as one of the most important vector born disease. With increasing cases, uncommon presentations and complications are now commonly recognized. Here, we report two cases of rare pattern of respiratory involvement in dengue: acute respiratory distress syndrome and bronchiolitis with respiratory failure. 相似文献
58.
59.
Swati Kumari Shikha Tewari Nuzhat Husain Akash Agarwal Anshuman Pandey Ashish Singhal Mohtashim Lohani 《Pathology oncology research : POR》2017,23(1):91-97
Gall bladder Carcinoma (GBC) is the fifth most common cancer of the digestive tract and frequently diagnosed in late stage of disease. Estimation of circulating free DNA (cfDNA) in serum has been applied as a “liquid biopsy” in several deep seated malignancies. Its value in diagnosis of gall bladder carcinoma has not been studied. The present study was designed to assess the role of cfDNA in the diagnosis of GBC and correlate levels with the TNM stage. Serum was collected from 34 patients with GBC and 39 age and sex matched controls including 22 cholecystitis and 17 healthy individuals. Serum cfDNA levels were measured through quantitative polymerase chain reaction (qPCR) by amplification of β-globin gene. Performance of the assay was calculated through the receiver operating characteristic (ROC) curve. The cfDNA level was significantly lower in healthy controls and cholecystitis (89.32 ± 59.76 ng/ml, 174.21 ± 99.93 ng/ml) compared to GBC (1245.91 ± 892.46 ng/ml, p = <0.001). The cfDNA level was significantly associated with TNM stage, lymph node involvement and jaundice (0.002, 0.027, and 0.041, respectively). Area under curve of ROC analysis for cancer group versus healthy and cholecystitis group was 1.00 and 0.983 with sensitivity of 100 %, 88.24 % and specificity of 100 % respectively. Quantitative analysis of cfDNA may distinguish cholecystitis and gall bladder carcinoma and may serve as new diagnostic, noninvasive marker adjunct to imaging for the diagnosis of GBC. 相似文献
60.