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Rengin Çetin Güvenç Nurgül Ceran Tolga Sinan Güvenç Hacer Ceren Tokgöz Yalçin Velibey 《Journal of cardiac failure》2018,24(9):583-593
Background
Involvement of right-sided heart chambers (RSHCs) in patients infected with human immunodeficiency virus (HIV) is common and is usually attributed to pulmonary arterial or venous hypertension (PH). However, myocardial involvement in patients with HIV is also common and might affect RSHCs even in the absence of overt PH. Our aim was to define morphologic and functional alterations in RSHC in patients with HIV and without PH.Methods and Results
A total of 50 asymptomatic patients with HIV and 25 control subjects without clinical or echocardiographic signs for PH were included in the study. Transthoracic echocardiography was used to obtain measurements. Patients with HIV had significantly increased right ventricular end-diastolic diameter (RVEDD) and right ventricular free wall thickness (RVFWT), as well as increased right atrial area and pulmonary arterial diameter, compared with control subjects. After adjustment for age, sex, and body surface area, RVFWT (average 1.81 mm, 95% confidence interval [CI] 0.35–3.26 mm) and RVEDD (average 6.82 mm, 95% CI 2.40–11.24 mm) were significantly higher in subjects infected with HIV. More patients with right ventricular hypertrophy were on antiretroviral treatment, and RVFWT was on average 1.3 mm higher (95% CI 0.24–2.37 mm) in patients on antiretroviral treatment after adjustment for confounders.Conclusions
These findings suggest that alterations in RSHCs were present in patients with HIV without PH. 相似文献45.
Neslihan Duruturk Eda Tonga Metin Karatas Ersin Doganozu 《Journal of Physical Therapy Science》2015,27(7):2023-2028
[Purpose] To describe the functional consequences of patients with cardiac diseases and
analyze associations between activity limitations and quality of life. [Subjects and
Methods] Seventy subjects (mean age: 60.1±12.0 years) were being treated by Physical
Medicine and Rehabilitation and Cardiology Departments were included in the study.
Activity limitations and participation restrictions as perceived by the individual were
measured by the Canadian Occupational Performance Measure (COPM). The Nottingham Extended
Activities of Daily Living (NEADL) Scale was used to describe limitations in daily living
activities. To detect the impact of activity limitations on quality of life the Nottingham
Health Profile (NHP) was used. [Results] The subjects described 46 different types of
problematic activities. The five most identified problems were walking (45.7%), climbing
up the stairs (41.4%), bathing (30%), dressing (28.6%) and outings (27.1%). The
associations between COPM performance score with all subgroups of NEADL and NHP; total,
energy, physical abilities subgroups, were statistically significant. [Conclusion] Our
results showed that patients with cardiac diseases reported problems with a wide range of
activities, and that also quality of life may be affected by activities of daily living.
COPM can be provided as a patient-focused outcome measure, and it may be a useful tool for
identifying those problems.Key words: Activity limitation, Cardiac diseases, Quality of life 相似文献
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Zafer Elbasan Mustafa Gür Sinan Kırım Selahattin Akyol Osman Kuloğlu 《Clinical and experimental hypertension (New York, N.Y. : 1993)》2014,36(3):153-158
N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts cardiovascular events and mortality in hypertensive patients. Relationship between NT-proBNP level and left ventricular (LV) hypertrophy is well known in hypertensive patients. However, the studies investigating relationship between LV geometric patterns and serum NT-proBNP level have conflicting results and are in a limited number. The goal of the present study is to investigate relation between NT-proBNP and abnormal LV geometric patterns in untreated hypertensive patients. Measurements were obtained from 273 patients with untreated essential hypertension (mean age?=?51.7?±?5.8 years) and 44 healthy control subjects (mean age; 51.3?±?4.7). Four different geometric patterns (NG: normal geometry; CR: concentric remodelling; EH: eccentric hypertrophy; CH: concentric hypertrophy) were determined according to LV mass index (LVMI) and relative wall thickness. NT-proBNP and other biochemical markers were measured in all subjects. The highest NT-proBNP levels were determined in the CH group compared with the control group and other geometric patterns (p?0.05). NT-proBNP levels of all geometric patterns were higher than the control group (p?0.05, for all). NT-proBNP levels were similar between CR and NG groups (p?>?0.05). NT-proBNP was independently associated with LV geometry (β?=?0.304, p?=?0.003) and LVMI (β?=?0.266, p?=?0.007) in multiple linear regression analysis. Serum NT-proBNP level was independently associated with LVMI and LV geometry in untreated hypertensive patients with preserved ejection fraction. 相似文献
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