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41.
Nils K. Raabe Rolf Kaaresen Sophie D. Fossaa 《Breast cancer research and treatment》1997,43(3):225-235
A retrospective review is presented of 1353 consecutivepatients with histopathologically confirmed invasive breast carcinoma treatedradically with curative intent during the decade 1980–89.None had received adjuvant systemic therapy with hormonesor prolonged chemotherapy. The distribution of lymph-node negative(N–) and lymph-node positive (N+) patients was 75%and 25%, respectively.The treatment and outcome were analysed as regardsconventional prognostic parameters, in particular considering the axillarylymph-node status and the responsible hospital category (GeneralMunicipal Hospitals (MH)) versus Comprehensive Cancer Center (CC)).The most striking difference was detected as regardsthe number of examined lymph nodes. The mediannumber of nodes described at the MH was7, as compared to 14 at the CC(p < 0.001). In patients with pT1 tumoursthe highest rate of lymph-node positivity was observedwhen 10 or more axillary nodes were removed.Adjuvant radiotherapy reduced the loco-regional recurrence rate inthe N– patients, whereas only the regional recurrenceswere reduced among the N+ patients. The five-and 10-year tumor-related survival rates were 86% and76%, respectively, with no difference between the MHand the CC.As life-prolonging adjuvant hormone therapy and chemotherapy isnow available for patients with axillary lymph nodemetastases, it is important that patients with breastcancer are operated adequately with the aim toremove at least 10 axillary lymph nodes. Athorough examination of the axillary content should beperformed by the pathologist, and the number ofresected lymph nodes and metastases should be reported.The establishment of nation-wide standard criteria for themanagement of breast cancer is recommended. 相似文献
42.
43.
Zimmermann M Seifert V Trantakis C Kühnel K Raabe A Schneider JP Dietrich J Schmidt F 《Acta neurochirurgica》2000,142(2):177-186
Summary ? Objectives. A number of different image-guided surgical techniques have been developed during the past decade. None of these methods
can provide the surgeon with information about the dynamic changes that occur intra-operatively. The development of open configurated
MRI-scanners leads to new perspectives in the intra-operative management and resection control of intracranial tumours.
Material and Method. Using a vertical open 0.5 T MRI-scanner for intra-operative MR image guided neurosurgery, forty-four patients (20 female/24
male) with different intracranial tumours have been operated on since August 1997. The patients ranged in age from 20 to 70
years (mean±standard deviation=47.2±15.9 ys).
Results. In 36 (82%) of 44 patients the tumours were completely removed with the aid of MR image-guidance. In 8 cases (18%) complete
removal was not achieved. Postoperatively 6 (14%) of 44 patients developed neurological deficits which were transient in 5
cases (paresis, dysphasia). In these patients the tumours were located in or near eloquent brain areas (sensorimotor cortex/speech
center).
Conclusion. Intra-operative MRI is helpful for navigation as well as determining of tumour margins to achieve a complete and safe resection
of intracranial lesions. Complications related to the surgical procedure are reduced and the risk of neurological deterioration
due to tumour removal and postoperative complications is minimized. It can be concluded that the intra-operative application
of interventional MRI technology may represent a major step foreward in the field of neurosurgery. 相似文献
44.
Cvirn G Cimenti C Kutschera J Ferstl U Wagner T Muntean W Jurgens G Gallistl S Koestenberger M 《European journal of pediatrics》2007,166(5):427-431
In the present study, we comparatively evaluated the anticoagulant efficacy of the new direct thrombin inhibitor melagatran
in cord vs. adult plasma. In contrast to heparin, melagatran does not require antithrombin as a cofactor. Thus, anticoagulant
treatment with melagatran is of special interest in neonatal patients, whose plasma is relatively deficient in antithrombin.
We evaluated the anticoagulant action of increasing amounts of melagatran (0.1–2.0 μmol/l) in both cord and adult plasma by
means of calibrated automated thrombography (CAT) with respect to the lag time until the onset of thrombin formation, time
to thrombin peak maximum (TTP), endogenous thrombin potential (ETP), and thrombin peak height. Melagatran exhibited approximately
the same ability to prolong lag times or TTPs in both cord and adult plasma. Similar concentrations (IC50) of melagatran were required to double the lag times (0.44±0.04 μmol/l vs. 0.52±0.05 μmol/l) or to double the TTPs (0.91±0.08 μmol/l
vs. 1.06±0.09 μmol/l) in cord vs. adult plasma. Melagatran exhibited a higher ability to suppress ETPs or thrombin peak heights
in cord vs. adult plasma. Markedly lower concentrations (IC50) of melagatran were required to suppress ETPs (0.27±0.03 μmol/l vs. 0.70±0.06 μmol/l) or thrombin peak heights by 50% (0.29±0.03 μmol/l
vs. 0.53±0.04 μmol/l) in cord vs. adult plasma. We conclude that our results suggest a higher ability of melagatran to suppress
thrombin formation in cord vs. adult plasma. Thus, lower amounts of melagatran might be required in neonates undergoing antithrombotic
therapy. 相似文献
45.
Ali Cheloee Darabi Shima Rastgordani Mohammadreza Khoshbin Vinzenz Guski Siegfried Schmauder 《Materials》2023,16(1)
A comprehensive approach to understand the mechanical behavior of materials involves costly and time-consuming experiments. Recent advances in machine learning and in the field of computational material science could significantly reduce the need for experiments by enabling the prediction of a material’s mechanical behavior. In this paper, a reliable data pipeline consisting of experimentally validated phase field simulations and finite element analysis was created to generate a dataset of dual-phase steel microstructures and mechanical behaviors under different heat treatment conditions. Afterwards, a deep learning-based method was presented, which was the hybridization of two well-known transfer-learning approaches, ResNet50 and VGG16. Hyper parameter optimization (HPO) and fine-tuning were also implemented to train and boost both methods for the hybrid network. By fusing the hybrid model and the feature extractor, the dual-phase steels’ yield stress, ultimate stress, and fracture strain under new treatment conditions were predicted with an error of less than 1%. 相似文献
46.
47.
Prof. Dr. Bruno Karitzky Siegfried Raabe Ilse Ugi 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1949,263(3-4):246-260
Zusammenfassung Die Wasserstoffzahl des Schweißes, der Gehalt an freien Wasserstoffionen, sagt nichts aus über die vorhandenen Säuren und Basen. Die Titrationsacidität, der gehalt des Schweißes an sauren und alkalischen Molekülen, wird durch Titration festgestellt. Wasserstoffzahl und Titrationsacidität im Spontanschweiß von Kranken unterscheiden sich wesentlich von PH und Titrationsacidität im Wärmeschweiß von Gesunden. Der Spontanschweiß enthält bedeutend mehr Säure und alkalische Substanz; sein PH bewegt sich in stätker sauren Bereichen und liegt oft tiefer als im Harn. Die Schweißfunktion ist eine Stoffwechselfunktion. Ursache der Schweißsekretion ist eine Stoffwechselstörung. Durch Schwitzen wird bei Bedarf das Stoffwechselgleichgewicht wiederhergestellt. Maßgebend für den Verlauf der Schweiß-PH-Kurve ist die Intensität des schweißtreibenden Reizes und die Wirksamkeit des inneren Schwitzeffektes. Maßgebend für die Titrationsacidität ist der Allgemeinzustand, insbesondere die Leistungsfähigkeit der übrigen Stoffwechselorgane. Aus Qualität und Quantität des Schweißes können zuverlässige Schlüsse auf die vegetative Gesamtlage gezogen werden. Plötzlicher Absturz und ungewöhnlich hoher Anstieg der PH-Kurve zeigen kritische Wendepunkte im Krankheitsverlaufe an. Kritische Schweiße und Nachtschweiße enthalten als titrierbare Substanz vorwiegend Säure, Todesschweiße und andere Erstickungsschweiße vorwiegend alkalische Stoffe in hoher Konzentration. Im einstündigen kritischen Schweiß können von Kranken mehr Säuren ausgeschwitzt werden, als im 24 Stundenharn durch die Nieren abgegeben werden. An der Heilwirkung der Schweißfunktion bei Krankheiten hat neben dem inneren Schwitzeffekt, der Vernichtung von Stoffwechselprodukten und Giften im Körper, der äußere Schwitzeffekt, die Ausscheidung von Säure, Toxin, Wasser und Salzen entscheidenden Anteil.Mit 10 Textabbildungen. 相似文献
48.
Dozent Dr. med. habil. Siegfried Mallow 《Archives of gynecology and obstetrics》1942,172(3):601-618
49.
50.