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11.
Primary angiitis of CNS : neuropathological study of three autopsied cases with brief review of literature 总被引:5,自引:0,他引:5
Primary angiitis of CNS(PACNS) or granulomatous angiitis of CNS is a rare inflammatory disease of small blood vessels mostly confined to the CNS. The clinical and pathological features of 3 autopsied cases are described. Clinically all the three PACNS patients were young males, age ranging from 19 to 31 years. All presented with varied neurological manifestations. There was no evidence of systemic disease in any of the cases. The ESR was normal and CSF analysis showed chronic meningitic pattern. The cerebral angiogram in one case was normal and the CT scan done in another case showed multiple intracerebral haematoma due to vasculitis. Brain biopsy was not done. Diagnosis was made at post-mortem examination. Histology showed characteristic but variable degree of granulomatous and non-granulomatous angiitis of small vessels. Venulitis with parenchymal haemorrhages was the predominant feature and in one case phlebitis with thrombosis was noted. Since the disease responds to steroids and immunosuppressive therapy, establishing antemortem diagnosis is important. In view of the association of angiitis of CNS with bacteria and viral infections, their role in the evolution of the disease needs to be investigated. 相似文献
12.
Surinder K. Singhal Naresh K. Panda S. B. S. Mann Ashim Dass 《Indian journal of otolaryngology and head and neck surgery》1997,49(3):265-268
Basaloid squamous cell carcinoma is a rare variant of squamous cell carcinoma, Larynx has been an uncommon site of this tumour
which is said to have aggressive biological behaviour with high incidence of cervical and distant metastasis along with second
primary. Two cases of laryngeal basaloid squamous cell carcinoma are reported with relevant review of literature. The submucosal
spread of tumour is highlighted alongwith role of preoperative radio therapy. 相似文献
13.
Jaimanti Naresh K. Panda Suresh Sharma Ashok K. Gupta S. B. S. Mann 《Indian journal of otolaryngology and head and neck surgery》2004,56(2):99-104
Conclusion Patients with stage I and II tumors had the best results with radical radiotherapy alone 5 years survival for patients with
stage I and stage II tumors was 90-95% and 75-85% respectively Patients with advanced stage III & IV disease were treated
Unoperable stage IV cancer patients had poor outcome and received only palliative treatment 相似文献
14.
Arunaloke Chakrabarti Ashim Das Naresh K Panda 《Indian journal of otolaryngology and head and neck surgery》2004,56(4):251-258
The incidence of fungal rhinosinusitis has increased to such extent in recent years that fungal infection should be considered
in all patients with chronic rhino sinusitis. In India though the disease was reported earlier only from northern regions
of this country, nowadays the disease is increasingly diagnosed from other parts as well. The disease has been categorized
with possible five types: acute necrothing (fulminant), chronic invasive, chronic granulomatous invasive, fungal hall (sinus
mycetoma), allergic. The first three types are tissue-invasive and the last two are non-invasive fungal rhinosinusitis. However,
the categorization is still controversial and open to discussion. Chronic fungal rhinosinusitis can occur in otherwise healthy
host and Aspergillus flavus is the common etiological agent in Indian scenario. The pathophys iologic mechanism of the disease
remains unclear. It may represent an allergic IgE response, a cell-mediated reaction, or a combination of two. Early diagnosis
may prevent multiple surgical procedures and lead to effective treatment. Histopathology and radio-imaging techniques help
to distinguish different types and delineate extension of disease process. Culture helps to identify the responsible etiological
agent. The presence or absence oj precipitating antibody correlates well with disease progression or recovery. The most immediate
need regarding management is to establish the respective roles of surgery and antifungal therapy. Non-invasive disease requires
surgical debridement and sinus ventilation only, though, additional oral or local corticosterold therapy may be beneficial
in allergie type. For invasive disease, the adjuvant medical therapy is recommended to prevent recurrence and further extension.
Itraconazole has been found as an effective drug in such situation. Patients with acute neerotizing type require radical surgery
and amphotericin B therapy. 相似文献
15.
Jaimanti Bakshi Naresh K. Panda Suresh C. Sharma Ashok Gupta S. B. S. Mann 《Indian journal of otolaryngology and head and neck surgery》2005,57(2):103-107
Carcinoma of larynx is a common disease in North Indian population. It is seen commonly in smokers and alcoholics. It poses a serious health problem due to its tendency to cause airway obstruction and to make the patient aphonic if total larynxgectomy is done for curing this cancer. We conducted a retrospective analysis in 690 cases of carcinoma larynx presenting to Nehru Hospital, Postgraduate Institute of Medical Education and Research, Chandigarh. Various aspects of this disease like predisposing factors, patterns of spread, histological types, various treatment modalities, their complications and response of this disease to these therapeutic options were studied in detail. 相似文献
16.
Naresh K. Panda Ekambar C. E. Reddy Rajiv J. Bapuraj 《Indian journal of otolaryngology and head and neck surgery》2005,57(2):150-152
Two cases of spontaneous cessation of cerebrospinal fluid (CSF) rhinorrhea following iohexol computerized tomographic (CT) cisternography are presented. This report contradicts the current thinking about conservative treatment in CSF rhinorrhea. We propose that iohexol CT cisternography may have a therapeutic role in the management of spontaneous CSF rhinorrhea. 相似文献
17.
Sharmeen Fatma Zeenat Iqbal Amulya Kumar Panda Lalit Mohan Negi Dinesh Giri Goswami 《Drug delivery》2016,23(2):500-511
AbstractA receptor level interaction of etoposide with P-glycoprotein (P-gp) and subsequent intestinal efflux has an adverse effect on its oral absorption. The present work is aimed to enhance the bioavailability of etoposide by co-administering it with quercetin (a P-gp inhibitor) in dual-loaded polymeric nanoparticle formulation. Poly-lactic-co-glycolic acid (PLGA) nanoparticles were optimized for various parameters like o/w phase volume ratio, poly-vinyl alcohol concentration, PLGA concentration and sonication time. The cytotoxicity studies (MTT assay) revealed a 9- and 11-fold decrease in the IC 50 values for etoposide-loaded nanoparticles (ENP) and etoposide?+?quercetin dual-loaded nanoparticles (EQNP) when compared to that of free etoposide, respectively, and the results were further supported by florescent-activated cell sorter studies. The confocal imaging of the intestinal sections treated with ENP and EQNP containing fluorescent probe (rhodamine) showed the superiority of the EQNP to permeate deeper. Furthermore, pharmacokinetic studies on rats revealed that EQNP exhibited a 2.4-fold increase in bioavailability of etoposide than ENP with no quercetin. The developed loaded nanoparticles have the high potential to enhance the bioavailability of the etoposide and sensitize the resistant cells. 相似文献
18.
S. Panda 《Pharmaceutical biology》2013,51(7):479-482
AbstractAn investigation was made to evaluate the effects of water and ethanol extracts of Piper nigrum L. fruits in the alteration of the serum thyroid hormone concentrations and tissue lipid peroxidation in liver, the main target organ of many drugs. The alcohol extract, at a dose of 4.0 mg/kg for 15 days, caused thyrotoxicosis as evidenced by increased concentrations of thyroxine and triiodothyronine. A concomitant increase in hepatic lipid peroxidation with a decrease in superoxide dismutase and/or catalase activities also indicated its peroxidative effect. However, a trial with the aqueous extract did not exhibit any toxic effect either on thyroid or in liver functions. Rather, the latter extract appeared to be antithyroidic and antiperoxidative in nature as it could decrease serum thyroid hormone concentrations and hepatic lipid peroxidation, respectively. It is suggested that the aqueous extract of Piper nigrum may be preferred over the alcohol extract for therapeutic uses. 相似文献
19.
Panda S 《Phytotherapy research : PTR》2008,22(12):1695-1697
An investigation was made to evaluate the role of Anethum graveolens L. (dill) leaf extract in the regulation of corticosteroid-induced type 2 diabetes mellitus in female rats. In dexamethasone-treated animals (1 mg/kg for 22 days) an increase in serum concentration of insulin and glucose and in hepatic lipid peroxidation (LPO) was observed. However, there was a decrease in serum concentration of thyroid hormones and in the endogenous antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) in liver. In animals treated with an equivalent amount of dexamethasone for a similar period (22 days) when received the leaf extract (100 mg/kg b.wt/d.) for last 15 days a decrease in the concentration of both serum glucose and insulin was observed, indicating the potential of the plant extract in the regulation of corticosteroid-induced diabetes. Dexamethasone-induced alterations in the levels of thyroid hormones as well as in hepatic LPO, SOD, CAT and GSH were also reversed by the plant extract. 相似文献
20.