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71.
72.
Fujiwara A Kobayashi H Masuya M Maruyama M Nakamura S Ibata H Fujimoto H Ohnishi M Urawa M Naito M Takagi T Kobayashi T Gabazza EC Takei Y Taguchi O 《Respirology (Carlton, Vic.)》2012,17(4):693-698
Background and objective: Interstitial lung diseases (ILD) are characterized by progressive interstitial pulmonary fibrosis and a decline in lung function. Fibrocytes are bone marrow‐derived mesenchymal progenitor cells that may play a role in the pathogenesis of pulmonary fibrosis. Circulating fibrocyte numbers have been correlated with the prognosis of patients with idiopathic pulmonary fibrosis. The aim of the present study was to evaluate the relationship between circulating fibrocytes, and parameters of disease activity and progression in several groups of patients with ILD. Methods: The study population comprised 41 patients with ILD and seven healthy control subjects. Circulating CD45+ collagen‐I+ fibrocytes were evaluated by flow cytometry. Results: The number of circulating fibrocytes was significantly increased in all patients with ILD and particularly in patients with idiopathic interstitial pneumonitis and interstitial pneumonitis associated with collagen vascular disease as compared with healthy control subjects. The numbers of circulating fibrocytes were significantly correlated with pulmonary function test parameters and with serum levels of sialylated carbohydrate antigen, a marker of disease activity. Temporal changes in circulating fibrocyte numbers were evaluated in two patients, and the results suggested that these changes correlated with the activity of ILD. Conclusions: The results from this study provide further evidence for the role of circulating fibrocytes in fibrotic lung diseases. 相似文献
73.
Morishita T Uzui H Nakano A Mitsuke Y Geshi T Ueda T Lee JD 《Journal of atherosclerosis and thrombosis》2012,19(2):149-158
74.
75.
Noboru Hanaoka MD Ryu Ishihara MD Yoji Takeuchi MD Motoyuki Suzuki MD Hirokazu Uemura MD Takashi Fujii MD Kunitoshi Yoshino MD Noriya Uedo MD Koji Higashino MD Takashi Ohta MD Hiromitsu Kanzaki MD Masao Hanafusa MD Kengo Nagai MD Fumi Matsui MD Hiroyasu Iishi MD Masaharu Tatsuta MD Yasuhiko Tomita MD 《Head & neck》2013,35(9):1248-1254
76.
Soji Ozawa Eisuke Ito Akihito Kazuno Osamu Chino Minoru Nakui Soichiro Yamamoto Hideo Shimada Hiroyasu Makuuchi 《Surgical endoscopy》2013,27(1):40-47
Background
In 2009, the rate of thoracoscopic esophagectomy for esophageal cancer was about 20 % in Japan. This low rate may be due to the difficulty in maintaining a good surgical field and the meticulous procedures that are required. The purpose of this study was to establish and evaluate a new procedure for performing a thoracoscopic esophagectomy while the patient is in a prone position using a preceding anterior approach to make the esophagectomy easier to perform.Methods
We have performed thoracoscopic esophagectomy using our new procedure in 60 patients with esophageal cancer. Each patient was placed in a prone position and five trocars were inserted; only the left lung was ventilated and a pneumothorax was maintained. The esophagus was mobilized from the anterior structure during the first step and from the posterior structure during the second step. The lymph nodes around the esophagus were also dissected anteriorly and posteriorly. The patients were sequentially divided into two groups and their clinical outcomes were evaluated.Results
The mean operative time for the thoracoscopic procedure for the latter 30 cases (203 min) was shorter than that for the former 30 cases (260 min) (P = 0.001). Among the 52 cases without pleural adhesion, the mean blood loss in the latter 26 cases (18 mL) was also less than that in the former 26 cases (40 mL) (P = 0.027). There were no conversions to a thoracotomy and no operative deaths in this series. Postoperative complications related to the thoracoscopic procedure occurred in 8 cases (27 %) in the former group and in 4 cases (13 %) in the latter group.Conclusions
Thoracoscopic esophagectomy with the patient in the prone position using a preceding anterior approach is a safe and feasible procedure. As experience performing the procedure increases, the performance of the procedure stabilizes. This method seems to make the esophagectomy easier to perform. 相似文献77.
78.
Shiori Otsuki Eiko Saito Norie Sawada Sarah K. Abe Akihisa Hidaka Taiki Yamaji Taichi Shimazu Atsushi Goto Motoki Iwasaki Hiroyasu Iso Tetsuya Mizoue Kenji Shibuya Manami Inoue Shoichiro Tsugane 《Annals of epidemiology》2018,28(9):597-604.e6
Purpose
We investigated the association between reproductive history and mortality from all and major causes among Japanese women.Methods
A large-scale population-based cohort study in Japan included 40,149 eligible women aged 40–69 years in 1990–1994. A total of 4788 deaths were reported during follow-up (average 20.9 years). A Cox proportional hazards regression model was used to estimate the hazard ratios (HRs) and 95% confidence intervals (95% CI) for all-cause and major causes of mortality, adjusting for potential confounders.Results
Inverse associations with all-cause mortality were found in parous women (0.74 [0.67–0.82]), women with two or three births compared with a single birth (2 births: 0.88 [0.78–0.99]; 3 births: 0.83 [0.74–0.94]), parous women who breastfed (0.81 [0.75–0.87]), women who were older at menopause (0.88 [0.80–0.97]; p-trend: <0.01), and women who had a longer fertility span (0.85 [0.76–0.95]; p-trend: <0.01). A positive association was seen between all-cause mortality and later age at first birth (≥30 years) than early childbearing (≤22 years).Conclusions
Our study suggests that parous, two or three births, breastfeeding, late age at menopause, and longer reproductive span are associated with lower risk of all-cause of mortality. 相似文献79.
This study determined the hardness and curing depth of a light-activated indirect composite polymerized with three laboratory light-polymerizing units for the purpose of comparing the curing performance of the three units. A light-activated composite material for indirect application (Vita Zeta) was polymerized with three light-polymerizing units equipped with the following light sources: 1) one halogen lamp and two fluorescent lamps (alpha-Light II); 2) three halogen lamps (Twinkle HLG); and 3) one metal halide lamp (Twinkle LI). Knoop hardness and curing depth were determined for groups of five specimens using standardized testing methods. The results were compared using analysis of variance (ANOVA) and Scheffé's S intervals (alpha = 0.05). The Knoop hardness number (KHN) generated with the halogen-fluorescent unit (12.5 KHN) was significantly (P < 0.05) lower than those produced by the halogen unit (13.9 KHN) and the metal halide unit (14.2 KHN). Of the three units, the halogen-fluorescent unit exhibited the lowest depth of cure. Both the hardness and curing depth of the composite were influenced by the laboratory polymerizing units employed. 相似文献
80.
Hiroyasu KOIZUMI Eiichi SUEHIRO Yuichi FUJIYAMA Kazutaka SUGIMOTO Takao INOUE Michiyasu SUZUKI 《Neurologia medico-chirurgica》2014,54(11):870-877
Intracranial pressure (ICP) measurements are fundamental in the present protocols for intensive care of patients during the acute stage of severe traumatic brain injury. However, the latest report of a large scale randomized clinical trial indicated no association of ICP monitoring with any significant improvement in neurological outcome in severely head injured patients. Aggressive treatment of patients with therapeutic hypothermia during the acute stage of traumatic brain injury also failed to show any significant beneficial effects on clinical outcome. This lack of significant results in clinical trials has limited the therapeutic strategies available for treatment of severe traumatic brain injury. However, combined application of different types of neuromonitoring, including ICP measurement, may have potential benefits for understanding the pathophysiology of damaged brains. The combination of monitoring techniques is expected to increase the precision of the data and aid in prevention of secondary brain damage, as well as assist in determining appropriate time periods for therapeutic interventions. In this study, we have characterized the techniques used to monitor patients during the acute severe traumatic brain injury stage, in order to establish the beneficial effects on outcome observed in clinical studies conducted in the past and to follow up any valuable clues that point to additional strategies for aggressive management of these patients. 相似文献