含镁极化液加能量合剂对心室晚电位的影响

用含镁极化液加能量合剂对心室晚电位阳性患者进行治疗观察,结果转阴率为81.8％,且治疗后QRS—D、LAS较治疗前明显缩短(P<0.025),RMS_(40)较治疗前明显升高(P<0.001)。并简要探讨其机理。     

Role of the pituitary tumor transforming gene 1 in the progression of hepatocellular carcinoma

In order to demonstrate the role of the pituitary tumor transforming gene 1 (PTTG1) in the development of hepatocellular carcinoma (HCC) and its value as a molecular target for cancer therapy, we analyzed the expression of PTTG1 mRNA and protein, and their relation to clinicopathological characteristics and basic fibroblast growth factor (bFGF) expression in HCC. It was observed that the level of PTTG1 mRNA and the positive rate of PTTG1 protein in cancerous tissues were significantly higher than that in adjacent non-cancerous tissues (both P< 0.001). The PTTG1 protein levels were correlated with several clinicopathological parameters, including alpha-fetoprotein level, portal vein tumor thrombosis, tumor stage, and bFGF protein level (P< 0.05). The proliferation indices were significantly less and the apoptotic rates were significantly higher in the HepG2 and SMMC-7721 cells treated with PTTG1 siRNA transfection than their untransfected counterparts. The expressions of Caspase-3, Bax, p21 and p53 in HepG2 and SMMC-7721 cells were significantly increased after siRNA knockdown of PTTG1 expression. In conclusion, the PTTG1 gene is up-regulated in the cancerous tissue from patients with HCC and involved in the progression of HCC. Inhibiting PTTG1 expression decreases cell proliferation and induces apoptosis in hepatic cancer cell lines, indicating that PTTG1 may be a new therapeutic target for HCC treatment.     

人参果皂甙的抗应激作用和对垂体—肾上腺皮质系统功能的影响

With various methods (temperature, swimming, hypoxia and toxicant), observations were made on the anti-stress effects of the saponins extracted from panax ginseng fruit (SPGF) injected intraperitoneally into white mice. The results obtained are as follows: SPGF exhibited a highly significant anti-hypoxia effect and anti-fatigue action. In addition, saponins strikingly raised the animals' ability to tolerate temperature stress and impede significantly the elevation of SGPT liver induced by injection of CCl₄. But this effect was abolished by the extirpation of the adrenals. Administration of SPGF by gavage caused marked depletion of adrenal ascorbic acid in intact rats. Stress condition and ACTH depleted the ascorbic acid content of the adrenals in rats. Previous administration of SPGF exhibited an inhibiting effect on such depletion. However, the adrenal ascorbic acid regulating effect of the compound disappeared in hypophysectomized rats. From these results, it would appear that SPGF has a stimulatory action on the hypophyseal—adrenal system.     

伯喹的氨基酸及二肽衍生物的合成

1981年,A.Trouet等报道了伯喹的氨基酸(亮氨酸)和肽类(丙氨酰——亮氨酸;丙氨酰——亮氨酰——丙氨酰——亮氨酸)衍生物作为前体药物,可降低伯喹的毒性并提高疗效。从报道的初步药理结果来看,二肽和四肽衍生物有降低毒性和提高疗效的作用。为寻找新的长效、低毒的伯喹衍生物,我们在过去研究工作的基础上又设计合成了一些不同于国外文献已报道的新衍生物:     

肺移植围术期治疗3例的经验和教训

目的 提高同种异体肺移植的治疗效果.方法 总结分析3例同种异体肺移植围术期治疗的经验和教训.结果 例1术后43 h撤离呼吸机,第4天移植肺细菌感染,第7天出现急性排斥反应,第14天因"右侧凝固性血胸"再次行右胸凝血块清除.例2术后48 h撤离呼吸机,第3天、第5天因左右胸腔先后出现活动性出血而再次剖胸止血,第6天出现急性排斥反应,第14天、第30天移植肺先后细菌、真菌感染.例3双肺移植术后并发桥脑中央髓鞘溶解症.结论 充分的术前准备和正确的围术期处理是肺移植成功的关键,重点是防治移植肺的早期失功能和围术期感染,同时早期监测急性排斥反应.     

骨痛胶囊治疗膝关节增生性关节炎的临床研究

目的:探讨骨痛胶囊治疗膝关节增生性关节炎的临床疗效和安全性。方法:60例患者随机分为两组。一组口服骨痛胶囊(30例),另一组口服抗骨增生胶囊(30例),分别于用药后7、14、21、28d进行评分,并对评分结果进行统计分析。结果:两组在改善症状方面均有明显效果(P<0.01)。受试组总有效率为90.00%,对照组80.00%,受试组的疗效优于对照组(P<0.01)。两组治疗单项症状均有效。两组均未出现明显的不良反应。结论:骨痛胶囊治疗增生性膝关节炎是安全、有效的药物。     

复方甘草酸苷预防抗结核药物致肝损伤的疗效观察

目的评估复方甘草酸苷预防抗结核药物致肝损伤的疗效。方法180例肺结核住院患者随机分为2组,对照组90例服用抗结核药物6个月~8个月,观察组90例在对照组用药基础上同时给予复方甘草酸苷片,观察2组治疗过程中肝损伤发生率等指标。结果2组肝损伤发生率分别为32.2%、8.9%(P<0.01)。结论复方甘草酸苷能有效预防抗结核药物所致肝损伤。     

围产期颅内静脉窦血栓形成的临床与影像分析

目的 探讨围产期颅内静脉窦血栓形成的发病机制、临床表现、影像学特点及治疗。方法 回顾分析24例围产期颅内静脉窦血栓形成患者的临床与影像学资料。结果 围产期颅内静脉窦血栓形成患者多以急性或亚急性高颅压症状为主，以上矢状窦血栓形成多见。结论 对于围产期女性，不明原因出现颅内压增高、局限性神经症状、癫痫发作、突然意识障碍的患者，须行头颅MRI＋MRV检查。     

经鼻高流量预充氧可保障老年患者全麻气管插管诱导期的安全

目的 评估经鼻高流量预充氧在老年患者全麻气管插管诱导期的安全性研究。方法 56例非困难气道老年患者,采用随机数字表法分为经鼻高流量吸氧组（HF组）和传统面罩经口鼻吸氧组（M组）,28例/组。全麻气管插管诱导给药前预充氧5 min,HF组喉镜检查期间维持给氧,M组通气持续到喉镜检查。观察并记录两组患者基本资料,预充氧前（T1）、预充氧5 min（T2）及插管成功即刻（T3）的超声下胃窦横截面积（CSA）和动脉血气分析指标：PaO2、PaCO2、cSO2,窒息安全时间,插管时间,面罩通气的次数及术后并发症。结果 两组患者的基本资料差异无统计学意义。预充氧5 min,两组患者的PaO2和cSO2均明显升高,且HF组PaO2较M组明显（F=118.108 vs 9.511,P<0.05）,插管成功后PaO2和cSO2均下降,HF组 的PaO2值较M组下降缓慢,且仍高于其T1时点,而M组的cSO2值下降显著,低于其T1时点值。HF组窒息安全时间显著高于M组（t=5.305,P<0.05）,且HF组面罩通气次数少于M组（χ2=6.720,P<0.05）。两组插管后的PaCO2值均增高,但两组比较差异无统计学意义（F=3.138,P>0.05）,其余结果差异也无统计学意义（P>0.05）。结论 经鼻高流量吸氧是一种安全简单有效的预充氧方式,与传统的面罩预充氧相比,能提高老年患者的动脉氧分压,延长患者窒息安全时间,可保障老年患者全麻诱导插管时气道管理的安全。