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Ogura Sho Kimura Muneyoshi Takagi Shinsuke Mitsuki Takashi Yuasa Mitsuhiro Kageyama Kosei Kaji Daisuke Nishida Aya Taya Yuki Ishiwata Kazuya Yamamoto Hisashi Asano-Mori Yuki Yamamoto Go Uchida Naoyuki Wake Atsushi Taniguchi Shuichi Araoka Hideki 《European journal of clinical microbiology & infectious diseases》2021,40(5):941-948
European Journal of Clinical Microbiology & Infectious Diseases - The aim of this study is to clarify the characteristics of gram-negative bacteremia (GNB), including extended-spectrum... 相似文献
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Yukitomo Ishi Ai Shimizu Emi Takakuwa Minako Sugiyama Michinari Okamoto Hiroaki Motegi Shinsuke Hirabayashi Yuko Cho Akihiro Iguchi Atsushi Manabe Sumihito Nobusawa Shinya Tanaka Shigeru Yamaguchi 《Pathology international》2021,71(5):348-354
A 5-year-old girl presented with headache and vomiting. Head computed tomography and magnetic resonance imaging showed a right frontal lobe tumor with marked calcification. The patient underwent resection surgery with suspicion of anaplastic ependymoma, and the tumor was gross totally removed. Pathological examination revealed areas of dense tumor cells with a high nucleocytoplasmic ratio and myxoid areas consisting of tumor cells with a round-shaped nucleus and eosinophilic cytoplasm. Perivascular pseudorosette, necrosis, circumscribed growth, and microcalcification were also observed. Immunohistochemistry demonstrated negative staining for glial fibrillary protein and epithelial membrane antigen. Diagnosis of a high-grade neuroepithelial tumor (HGNET) with BCL6 corepressor (BCOR) alteration was made based on pathological findings and internal tandem duplication in the exon 15 of BCOR. Although calcification on radiological and pathological examination is not typical, it would be essential to recognize that calcification could appear in HGNET-BCOR. 相似文献
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Diffusion‐weighted magnetic resonance imaging for evaluating the histological degree of malignancy in patients with intraductal papillary mucinous neoplasm 下载免费PDF全文
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Sasaki K Kazama S Sunami E Tsuno NH Nozawa H Nagawa H Kitayama J 《Diseases of the colon and rectum》2012,55(1):72-78
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Onizuka T Yuasa S Kusumoto D Shimoji K Egashira T Ohno Y Kageyama T Tanaka T Hattori F Fujita J Ieda M Kimura K Makino S Sano M Kudo A Fukuda K 《Journal of molecular and cellular cardiology》2012,52(3):650-659
The efficient induction of cardiomyocyte differentiation from embryonic stem (ES) cells is crucial for cardiac regenerative medicine. Although Wnts play important roles in cardiac development, complex questions remain as to when, how and what types of Wnts are involved in cardiogenesis. We found that Wnt2 was strongly up-regulated during cardiomyocyte differentiation from ES cells. Therefore, we investigated when and how Wnt2 acts in cardiogenesis during ES cell differentiation. Wnt2 was strongly expressed in the early developing murine heart. We applied this embryonic Wnt2 expression pattern to ES cell differentiation, to elucidate Wnt2 function in cardiomyocyte differentiation. Wnt2 knockdown revealed that intrinsic Wnt2 was essential for efficient cardiomyocyte differentiation from ES cells. Moreover, exogenous Wnt2 increased cardiomyocyte differentiation from ES cells. Interestingly, the effects on cardiogenesis of intrinsic Wnt2 knockdown and exogenous Wnt2 addition were temporally restricted. During cardiomyocyte differentiation from ES cells, Wnt2 didn't activate canonical Wnt pathway but utilizes JNK/AP-1 pathway which is required for cardiomyocyte differentiation from ES cells. Therefore we conclude that Wnt2 plays strong positive stage-specific role in cardiogenesis through non-canonical Wnt pathway in murine ES cells. 相似文献