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71.
Takashi Nakahara Hideyuki Hyogo Yuki Kimura Tomokazu Ishitobi Koji Arihiro Hiroshi Aikata Shoichi Takahashi Kazuaki Chayama 《Hepatology research》2012,42(11):1065-1072
Aim: Statins, an inhibitor of 3‐hydroxy‐3‐methylglutaryl‐coenzyme A (HMG‐CoA) reductase, are reported to be useful for the treatment of non‐alcoholic steatohepatitis (NASH). Currently, there is no proven therapy for NASH. In this study, we assessed the efficacy of rosuvastatin in NASH patients with dyslipidemia. Methods: Nineteen patients with biopsy‐proven NASH with dyslipidemia who agreed to participate in this prospective study were enrolled. The patients were treated for 24 months with 2.5 mg/day rosuvastatin. Clinical and histological alterations were comparatively evaluated before and after treatment. Standard weight‐loss counseling was continued during the treatment period. Follow‐up liver biopsy was performed in nine patients. Results: Twenty‐six percent of patients had hyperlipoproteinemia type IIa and 74% had hyperlipoproteinemia type IIb at baseline. Body mass indices were not significantly changed during the treatment. The levels of transaminases were relatively low at the beginning, and were not significantly changed during the treatment. Lipid profiles were significantly improved by the treatment with rosuvastatin for 24 months. While non‐alcoholic fatty liver disease activity score and fibrotic stage did not change significantly in all patients, they were improved in 33.3% and 33.3% individual patients, and stayed stable in 33.3% and 55.6%, respectively. Conclusion: NASH‐related metabolic parameters improved with therapy including histology in some patients. However, one of nine patients had progression of fibrosis during the treatment. Our pilot study demonstrated the efficacy of rosuvastatin for the treatment of NASH with dyslipidemia, even if transaminases are not so elevated and controlled trials are needed in the future. 相似文献
72.
73.
Tetsuya Hiraishi Toshio Matsushima Masatou Kawashima Yukiko Nakahara Yuichi Takahashi Hiroshi Ito Makoto Oishi Yukihiko Fujii 《Neurosurgical review》2013,36(4):629-635
The affected artery in glossopharyngeal neuralgia (GPN) is most often the posterior inferior cerebellar artery (PICA) from the caudal side or the anterior inferior cerebellar artery (AICA) from the rostral side. This technical report describes two representative cases of GPN, one with PICA as the affected artery and the other with AICA, and demonstrates the optimal approach for each affected artery. We used 3D computer graphics (3D CG) simulation to consider the ideal transposition of the affected artery in any position and approach. Subsequently, we performed microvascular decompression (MVD) surgery based on this simulation. For PICA, we used the transcondylar fossa approach in the lateral recumbent position, very close to the prone position, with the patient’s head tilted anteriorly for caudal transposition of PICA. In contrast, for AICA, we adopted a lateral suboccipital approach with opening of the lateral cerebellomedullary fissure, to visualize better the root entry zone of the glossopharyngeal nerve and to obtain a wide working space in the cerebellomedullary cistern, for rostral transposition of AICA. Both procedures were performed successfully. The best surgical approach for MVD in patients with GPN is contingent on the affected artery—PICA or AICA. 3D CG simulation provides tailored approach for MVD of the glossopharyngeal nerve, thereby ensuring optimal surgical exposure. 相似文献
74.
Toshinori Nakahara Munenori Kutsuna Masami Yamanaka Katsuaki Sakoda 《Neurological research》2013,35(3):324-326
AbstractThe present paper describes a double coil-delivered microcatheter technique used in combination with a balloon-assisted technique to treat a patient with a large, wide-necked basilar tip aneurysm with detachable coil treatment. The aneurysm was completely occluded using this technique. There was no recanalization or any neurological deterioration within 12 months of embolization. [Neurol Res 1999; 21: 324-326] 相似文献
75.
Yasue Nishii Shinnosuke Kawata Naoto Fujita Koichi Tomoda Hidetaka Imagita 《Sport Sciences for Health》2016,12(1):91-97
Purpose
Our aim was to investigate whether exercise would ameliorate the impaired diaphragm muscle function and the inflammation induced by cigarette smoke solution (CSS) and endotoxin in rat lungs.Methods
We induced inflammation using intratracheal injections of CSS plus endotoxin in rats. After 2 weeks (day 15), half of these rats (CSS-Run group) began daily treadmill exercise (CSS-Run group) and the other half remained sedentary (CSS group). A third group received intratracheal saline injections and remained sedentary (sham group). Injections continued for 28 days during the study period. To investigate inflammation in the lungs, respiratory function was evaluated and leukocytes were measured. Muscle tension was measured in diaphragm and skeletal muscles, and muscle morphology was histochemically assessed.Results
Compared with the sham group, the inspiratory to expiratory ratios were significantly higher in the CSS group but not in the CSS-Run group. Treadmill exercise increased the percentage of circulating neutrophils. Histology of lungs from the CSS group and the CSS-Run group showed proliferating macrophages; however, aggregation and cell numbers were more remarkable in the CSS group. The peak diaphragm muscle twitch force was significantly higher in the CSS-Run group than in the sham group; additionally, the relative area of fast-twitch glycolytic fibers was more extensive (P < 0.01).Conclusions
We demonstrated that 2 weeks of treadmill exercise improved airway resistance and diaphragm muscle contractile force in rats exposed to repetitive CSS plus endotoxin. We propose that local inflammation was attenuated by aerobic exercise, which increased diaphragm muscle contractility.76.
Hip range‐of‐motion (ROM) is less than normal after rotational acetabular osteotomy for developmental dysplasia of the hip: A simulated ROM analysis
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Hidetoshi Hamada Masaki Takao Ichiro Nakahara Takashi Sakai Takashi Nishii Nobuhiko Sugano 《Journal of orthopaedic research》2016,34(2):217-223
The optimal reorientation of the acetabulum for developmental dysplasia of the hip (DDH) is unknown in terms of hip range‐of‐motion (ROM). The simulated ROMs of 52 DDHs after rotational acetabular osteotomy (RAO) with several patterns of femoral head coverage and those of 73 normal hips were analyzed using computer models reconstructed from CT images. After RAO with a lateral center edge angle (LCEA) of 30° and an anterior center edge angle (ACEA) of 55° producing coverage similar to that of normal hips, the maximal flexion and maximal internal rotation at 110° flexion with 20° adduction were significantly smaller than those of the normal group. To achieve ROMs after RAO similar to those of the normal group, an LCEA of 30° with an ACEA of 45°, an LCEA of 25° with an ACEA of 45° to 50°, and an LCEA of 20° with an ACEA of 50° could be preferred angles to target, even though they provided smaller coverage than that of normal hips. After RAO producing femoral head coverage similar to that of normal hips, the maximal flexion and the maximal internal rotation at 110° flexion with 20° adduction were significantly smaller than those of the normal group. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:217–223, 2016. 相似文献
77.
This study was designed to properly characterize the cephalometric values of Japanese individuals with both normal occlusion and esthetic profiles. Multivariate statistics were applied to analyze the collected data. Cephalometric values identified are expected to help in the simplification of orthodontic diagnosis. Lateral cephalometric radiographs from 50 men and 50 women with normal occlusion were traced and the dimensions of hard and soft tissues recorded. The corresponding values were classified by cluster analysis, and selected representative values were subjected to principal component analysis. From these values, characteristics of hard and soft tissue morphology were extracted. The subjects were grouped by sex, and subdivided into esthetic and unesthetic profile groups. The principal component scores from each group were plotted on a scattergram and the characteristics of each group investigated. The hard tissue characteristics in men with esthetic profiles were primarily vertical factors, including a tendency for smaller lower facial heights, a smaller mandibular plane angle, and a larger Nasion-ANS/ANS-Menton (N-ANS/ANS-Me). Soft tissue features included a more posteriorly placed maxilla and a high nasal crest. These features yield a less marked maxillary prognathism and a greater nose prominence. In females, hard tissue characteristics associated with esthetic profiles primarily involved the cranial base and posterior facial area. These included a smaller saddle angle, larger articulare angle, and smaller Sella-Articulare/Articlare-Gonion (S-Ar/Ar-Go). Female soft tissue characteristics primarily included retracted upper and lower lips, a shallow inferior sulcus with a smaller lower lip-Frankfort plane angle, and a shorter mentolabial sulcus and subnasale perpendicular-upper lip. 相似文献
78.
79.
Shirahama Shintaro Kaburaki Toshikatsu Takada Sachiko Nakahara Hisae Tanaka Rie Komae Keiko Fujino Yujiro Kawashima Hidetoshi Aihara Makoto 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(3):639-645
Graefe's Archive for Clinical and Experimental Ophthalmology - To clarify the prevalence of secondary glaucoma (SG) and its speed of progression in patients with herpes simplex virus... 相似文献
80.
Masui Daisuke Fukahori Suguru Hashizume Naoki Ishii Shinji Higashidate Naruki Koga Yoshinori Sakamoto Saki Tsuruhisa Shiori Nakahara Hirotomo Saikusa Nobuyuki Tanaka Yoshiaki 《Esophagus》2022,19(2):360-366
Esophagus - Development of gastroesophageal reflux disease (GERD) after gastrostomy remains debatable. Therefore, this study aimed to evaluate whether laparoscopy-aided gastrostomy (LAG) influence... 相似文献