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Teppei TANAKA Motoharu HAYAKAWA Akiyo SADATO Kazuhide ADACHI Takeya WATABE Shingo MAEDA Masahiro OHMURA Yuichi HIROSE 《Neurologia medico-chirurgica》2014,54(2):155-160
The vascular type of Ehlers-Danlos syndrome (vEDS) is an autosomal dominant hereditary disease characterized by connective tissue fragility throughout the body, including the arteries, viscera, and gastrointestinal tract. We report a case in which we performed transvenous embolization (TVE) via direct superior ophthalmic vein (SOV) approach to treat a direct carotid-cavernous fistula (CCF) in a patient with Ehlers-Danlos syndrome (EDS). The patient was a 37-year-old woman who developed tinnitus in her left ear and a headache during examination in the outpatient clinic of another hospital in order to make a definitive diagnosis of vEDS, and she was referred to our hospital and examined. Based on the results of all of the studies she was diagnosed with a CCF. Conservative treatment was attempted, but was not very effective. Because of progressing aphasia, TVE was performed via the SOV direct cut. There were no intraoperative or postoperative complications. It has been reported that cerebral angiography is generally contraindicated in vEDS and that the morbimortality associated with endovascular treatment is very high. When performing treatment it is necessary to be sufficiently aware of the risks it entails. 相似文献
77.
Immunohistochemical expression profiles of solute carrier transporters in alpha‐fetoprotein‐producing gastric cancer
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Hideaki Hozumi Ryota Hokari Motonori Shimizu Koji Maruta Kazuyuki Narimatsu Hirokazu Sato Shingo Sato Toshihide Ueda Masaaki Higashiyama Chikako Watanabe Shunsuke Komoto Kengo Tomita Atsushi Kawaguchi Shigeaki Nagao Soichiro Miura 《Digestive endoscopy》2014,26(4):594-598
Phlebosclerotic colitis is a rare and recently known disease entity and its etiology is still to be elucidated. Some phlebosclerotic colitis cases are difficult to distinguish from collagenous colitis because of the similarity of pathological findings. In all Japanese case reports of phlebosclerotic colitis in which an association with the use of Chinese herbal medicine is suspected, sansisi (gardenia fruit) was included, suggesting pathogenesis of this disease. We report a case of phlebosclerotic colitis that wasdifficult to be distinguished from collagenous colitis, and an association with the use of Chinese herbal medicine was suspected as the cause of the disease. 相似文献
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Takashi Uchiyama Hirokazu Takahashi Hiroki Endo Shingo Kato Eiji Sakai Kunihiro Hosono Masato Yoneda Masahiko Inamori Yoshitaka Hippo Hitoshi Nakagama Atsushi Nakajima 《Digestive endoscopy》2012,24(5):353-357
Aim: Endoscopic screening and removal of colorectal adenomas can reduce the incidence of colorectal cancer. However, given the possibility of adenoma recurrence, surveillance colonoscopy is currently recommended after the initial screening and removal of colorectal adenomas. Aberrant crypt foci (ACF) have been shown to serve as a reliable surrogate marker of colorectal carcinogenesis. In this study, the relationship between the number of ACF at the initial endoscopic polypectomy and the likelihood of colorectal adenoma recurrence after polypectomy were investigated. Methods: High‐magnification chromoscopic colonoscopy was performed in 82 subjects who underwent endoscopic polypectomy to identify ACF in the lower rectum. Surveillance colonoscopy was then performed 3 years after the baseline polypectomy at Yokohama City University Hospital. Results: The number of ACF was greater in patients who showed adenoma recurrence (7.88 ± 6.35) than in those who did not (2.19 ± 2.95) (P < 0.001). Receiver–operating curve analysis showed that the number of ACF was a highly specific predictor of the risk of adenoma recurrence. Conclusions: This is the first study conducted to investigate the relationship between the number of ACF after endoscopic polypectomy and the likelihood of recurrence of colorectal adenomas. These results suggest that the number of ACF is a useful predictor of the likelihood of colorectal adenoma recurrence. 相似文献
80.
Shingo Shibata Chiori Ueno Tsuyoshi Ito Keitaro Yamanouchi Takashi Matsuwaki Masugi Nishihara 《Age (Dordrecht, Netherlands)》2010,32(2):239-253
Growth hormone (GH) is known to have a pivotal role in the maintenance of skeletal muscle mass. Sarcopenia, the loss of skeletal
muscle mass, is a common phenomenon in aging, and it is widely accepted that sarcopenia is largely attributed to age-related
decline in GH secretion. In the present study, we tested if human growth hormone transgenic rats (GH-TG rats) whose plasma
GH levels are maintained relatively low could be an appropriate model for sarcopenia. Analyses of GH-TG rats revealed that
they exhibit skeletal muscle growth defect as well as atrophy of myofibers. The number of myofibers in tibialis anterior muscle
was comparable to that of WT rats, while the proportion of type I slow myofibers in tibialis anterior muscle was increased
in GH-TG rats after 5 months. Neither increased expression of ubiquitin ligases, MuRF1 and MAFbx, nor indication of apoptotic
cell death was observed. Notably, myogenic differentiation potential of skeletal muscle progenitor cells in GH-TG rats was
lower than WT rats, and this was accompanied by increased adipogenic potential. These results indicate that GH-TG rats could
be a useful model to elucidate the mechanism of sarcopenia induced by reduced GH action and raised the possibility that decreased
GH action may cause an alteration of differentiation potential of skeletal muscle progenitor cells. 相似文献