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851.
Souza-Moreira TM Severi JA Santos E Silva VY Vilegas W Salgado HR Pietro RC 《Journal of medicinal food》2011,14(12):1590-1596
Plinia cauliflora (Mart.) Kausel, widespread in South America, has edible fruits, and its bark is commonly used against diarrhea and other disorders, on account of its astringency. Because diarrhea is still one of the most important causes of illness and death among children in developing countries, where the population turns to traditional medicine for its treatment, the present study determined the composition of fruit and leaf extracts of P. cauliflora, analyzed the activity against diarrhea by antimicrobial and gastrointestinal motility, and evaluated the cytotoxicity of the extracts. Chemical composition was determined by high-performance liquid chromatograpy-ultraviolet/photodiode array detection. Antimicrobial activity was analyzed by agar diffusion and the microdilution method against etiological agents of diarrhea. The effect on gastrointestinal motility was analyzed using an experimental model in mice. Cytotoxicity was evaluated in vitro with the fibroblast cell line SIRC CCL 60, and leaf extract showed a 50% inhibitory concentration of 0.48 μg/mL. Gallic acid, ellagic acid, and flavonoid derivatives were detected in the extracts. It was observed that fruit and leaf extracts showed some activity against Enterococcus faecalis, Escherichia coli, Salmonella sp., and Shigella sp. However, neither extract had any effect on gastrointestinal motility. 相似文献
852.
SUETONIA C PALMER SANKAR D NAVANEETHAN GIOVANNI FM STRIPPOLI 《Nephrology (Carlton, Vic.)》2010,15(2):158-164
A systematic review provides the best summary of evidence for clinical decision‐making in nephrology by summarizing all the primary studies that evaluate a specific clinical question. By using rigorous and pre‐specified methods, conclusions about the overall effect of an intervention can be more reliable, precise and comprehensive in a systematic review than those derived from individual studies. In this article, we describe the key components of a systematic review and meta‐analysis. We summarize the features of a systematic review that should be looked for when considering the accuracy and validity of its results – particularly when applying the outcomes of a systematic review to a clinical question. 相似文献
853.
Daisy JA Janssen Martijn A Spruit Joan D Does Jos MGA Schols Emiel FM Wouters 《BMC palliative care》2010,9(1):6
COPD is nowadays the main indication for lung transplantation. In appropriately selected patients with end stage COPD, lung
transplantation may improve quality of life and prognosis of survival. However, patients with end stage COPD may die while
waiting for lung transplantation. Palliative care is important to address the needs of patients with end stage COPD. This
case report shows that in a patient with end stage COPD listed for lung transplantation offering palliative care and curative-restorative
care concurrently may be problematic. If the requirements to remain a transplantation candidate need to be met, the possibilities
for palliative care may be limited. Discussing the possibilities of palliative care and the patient's treatment preferences
is necessary to prevent that end-of-life care needs of COPD patients dying while listed for lung transplantation are not optimally
addressed. The patient's end-of-life care preferences may ask for a clear distinction between the period in which palliative
and curative-restorative care are offered concurrently and the end-of-life care period. This may be necessary to allow a patient
to spend the last stage of life according to his or her wishes, even when this implicates that lung transplantation is not
possible anymore and the patient will die because of end stage COPD. 相似文献
854.
855.
Ibrahim Al-Nasser Ashraf M Anwar Youssef FM Nosir Mohammed AR Chamsi-Pasha Aref Ajam Aymen Alqiriaqri Hassan Chamsi-Pasha 《Journal of cardiovascular magnetic resonance》2008,10(1):1-3
Aims
to investigate the association between admission hyperglycemia and myocardial damage in patients with ST-segment elevation myocardial infarction (STEMI) using Cardiac Magnetic Resonance (CMR).Methods
We analyzed 113 patients with STEMI treated with successful primary percutaneous coronary intervention. Admission hyperglycemia was defined as a glucose level ≥ 7.8 mmol/l. Contrast-enhanced CMR was performed between 3 and 7 days after reperfusion to evaluate left ventricular function and perfusion data after injection of gadolinium-DTPA. First-pass images (FP), providing assessment of microvascular obstruction and Late Gadolinium Enhanced images (DE), reflecting the extent of infarction, were investigated and the extent of transmural tissue damage was determined by visual scores.Results
Patients with a supramedian FP and DE scores more frequently had left anterior descending culprit artery (p = 0.02 and <0.001), multivessel disease (p = 0.02 for both) and hyperglycemia (p < 0.001). Moreover, they were characterized by higher levels of HbA1c (p = 0.01 and 0.04), peak plasma Creatine Kinase (p < 0.001), left ventricular end-systolic volume (p = 0.005 and <0.001), and lower left ventricular ejection fraction (p = 0.001 and <0.001). In a multivariate model, admission hyperglycemia remains independently associated with increased FP and DE scores.Conclusion
Our results show the existence of a strong relationship between glucose metabolism impairment and myocardial damage in patients with STEMI. Further studies are needed to show if aggressive glucose control improves myocardial perfusion, which could be assessed using CMR. 相似文献856.
Corsi C Tomasi C Turco D Margheri M Lamberti C Severi S 《Medical & biological engineering & computing》2011,49(8):901-908
Although cardiac resynchronization therapy (CRT) is an effective treatment for chronic systolic heart failure with dyssynchrony,
about one-third of patients do not respond favorably. The interaction between the pacing lead and the coronary sinus (CS)
branches is of paramount importance for an effective resynchronization. Minor changes in lead position overtime could interfere
with CRT mechanics, without affecting even biophysical parameters or ECG morphology. Although late post-implant CS lead dislodgement
rate is consistent, lead movements have been little investigated and only with bi-dimensional methods. The aim of this study
was (1) to develop a method for quantifying CS lead position in the 3D domain throughout the cardiac cycle and (2) to test
it by comparing the CS lead position at implant and at follow-up, using chest fluoroscopy. Method performance, its accuracy
and reproducibility were qualitatively and quantitatively assessed. Intra- and inter-observer percent discordance between
trajectories were also computed. The accuracy of the procedure resulted in 0.3 ± 0.1 mm and its resolution was 0.5 mm. Intra-
and inter-observer discordances were 2.2 ± 1.5 and 5.5 ± 3.6 mm, respectively. The proposed method for measuring the CS lead
dynamic placement in 3D space seems accurate and reproducible. Investigating CS lead 3D dynamics could provide further insights
into CRT mechanics. 相似文献
857.
Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers: Findings from a prospective cohort study 下载免费PDF全文
Magdalena Stepien Talita Duarte‐Salles Veronika Fedirko Anne Floegel Dinesh Kumar Barupal Sabina Rinaldi David Achaintre Nada Assi Anne Tj?nneland Kim Overvad Nadia Bastide Marie‐Christine Boutron‐Ruault Gianluca Severi Tilman Kühn Rudolf Kaaks Krasimira Aleksandrova Heiner Boeing Antonia Trichopoulou Christina Bamia Pagona Lagiou Calogero Saieva Claudia Agnoli Salvatore Panico Rosario Tumino Alessio Naccarati H. B. Bueno‐de‐Mesquita Petra H. Peeters Elisabete Weiderpass J. Ramón Quirós Antonio Agudo María‐José Sánchez Miren Dorronsoro Diana Gavrila Aurelio Barricarte Bodil Ohlsson Klas Sj?berg M?rten Werner Malin Sund Nick Wareham Kay‐Tee Khaw Ruth C. Travis Julie A. Schmidt Marc Gunter Amanda Cross Paolo Vineis Isabelle Romieu Augustin Scalbert Mazda Jenab 《International journal of cancer. Journal international du cancer》2016,138(2):348-360
Perturbations in levels of amino acids (AA) and their derivatives are observed in hepatocellular carcinoma (HCC). Yet, it is unclear whether these alterations precede or are a consequence of the disease, nor whether they pertain to anatomically related cancers of the intrahepatic bile duct (IHBC), and gallbladder and extrahepatic biliary tract (GBTC). Circulating standard AA, biogenic amines and hexoses were measured (Biocrates AbsoluteIDQ‐p180Kit) in a case‐control study nested within a large prospective cohort (147 HCC, 43 IHBC and 134 GBTC cases). Liver function and hepatitis status biomarkers were determined separately. Multivariable conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (OR; 95%CI) for log‐transformed standardised (mean = 0, SD = 1) serum metabolite levels and relevant ratios in relation to HCC, IHBC or GBTC risk. Fourteen metabolites were significantly associated with HCC risk, of which seven metabolites and four ratios were the strongest predictors in continuous models. Leucine, lysine, glutamine and the ratio of branched chain to aromatic AA (Fischer's ratio) were inversely, while phenylalanine, tyrosine and their ratio, glutamate, glutamate/glutamine ratio, kynurenine and its ratio to tryptophan were positively associated with HCC risk. Confounding by hepatitis status and liver enzyme levels was observed. For the other cancers no significant associations were observed. In conclusion, imbalances of specific AA and biogenic amines may be involved in HCC development. 相似文献
858.
Anna Simonelli Mattia Severi Leonardo Trombelli Roberto Farina 《Periodontology 2000》2023,91(1):20-44
The modern approach to regenerative treatment of periodontal intraosseous defects should aim at maximizing the clinical outcomes while minimizing the invasiveness (pain, complications, aesthetic impairment, chair time, and costs) of the procedure. The present systematic review evaluated the effect of flap design, regenerative technology, and perioperative and postoperative adjunctive protocols on invasiveness. Overall, the results of the 13 included trials indicate that: (a) the elevation of a single (buccal or lingual) flap positively influences the intensity of postoperative pain and improves the quality of early wound healing compared with double flaps; (b) while the adjunctive use of a membrane is associated with significantly longer surgery-related chair time and higher postoperative pain, the adjunctive use of enamel matrix derivative at sites receiving a graft significantly reduces postoperative pain; also, graft materials showed no significant impact on invasiveness; (c) open flap debridement performed through the elevation of a single flap may lead to substantial clinical improvements of the lesion with reduced surgery-related chair time and costs, thus representing a promising alternative to regenerative treatment. However, for such an approach, a histological evaluation of the nature of the reconstructed tissues is still lacking, and the presurgery conditions (eg, probing depth, defect severity, and defect morphology), which may benefit in terms of invasiveness, have not yet been defined; and (d) intraoperative and postoperative low-level laser biostimulation of the defect site may favorably modulate the postoperative course. 相似文献
859.
860.
Mattia Severi Leonardo Trombelli Lisa Heitz-Mayfield Roberto Farina Anna Simonelli 《Periodontology 2000》2023,91(1):113-125
The presence of a peri-implant bone dehiscence (BD) or fenestration (BF) is a common finding after implant placement in a crest with a reduced bucco-lingual bone dimension. The presence of a residual BD is associated with a relevant incidence of peri-implant biological complications over time. Guided bone regeneration (GBR), performed at implant placement, is the most validated treatment to correct a BD. In the present systematic review, the evidence evaluating factors which could reduce the invasiveness of a GBR procedure with respect to patient-reported outcomes, intra- and post- surgical complications, was summarized. Factors included were: technical aspects, regenerative materials for GBR, and peri- and post-operative pharmacological regimens. The available evidence seems to indicate that the use of membrane fixation and flap passivation by means of a double flap incision technique may reduce the incidence of post-surgical complications. When feasible, the coronal advancement of the lingual flap is suggested. The use of a non-cross linked resorbable membrane positively impacts on patient discomfort. The adjunctive use of autogenous bone to a xenograft seems not to improve BD correction, but could increase patient discomfort. Systemic antibiotic administration after a GBR procedure does not seem to be justified in systemically healthy patients. 相似文献