全文获取类型
收费全文 | 5692篇 |
免费 | 403篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 91篇 |
妇产科学 | 97篇 |
基础医学 | 828篇 |
口腔科学 | 91篇 |
临床医学 | 610篇 |
内科学 | 1323篇 |
皮肤病学 | 105篇 |
神经病学 | 780篇 |
特种医学 | 192篇 |
外科学 | 828篇 |
综合类 | 22篇 |
预防医学 | 333篇 |
眼科学 | 115篇 |
药学 | 359篇 |
中国医学 | 14篇 |
肿瘤学 | 309篇 |
出版年
2023年 | 24篇 |
2022年 | 59篇 |
2021年 | 119篇 |
2020年 | 62篇 |
2019年 | 116篇 |
2018年 | 158篇 |
2017年 | 97篇 |
2016年 | 105篇 |
2015年 | 135篇 |
2014年 | 154篇 |
2013年 | 248篇 |
2012年 | 408篇 |
2011年 | 432篇 |
2010年 | 240篇 |
2009年 | 222篇 |
2008年 | 381篇 |
2007年 | 395篇 |
2006年 | 387篇 |
2005年 | 399篇 |
2004年 | 345篇 |
2003年 | 338篇 |
2002年 | 307篇 |
2001年 | 61篇 |
2000年 | 53篇 |
1999年 | 57篇 |
1998年 | 75篇 |
1997年 | 71篇 |
1996年 | 47篇 |
1995年 | 49篇 |
1994年 | 43篇 |
1993年 | 48篇 |
1992年 | 32篇 |
1991年 | 23篇 |
1990年 | 27篇 |
1989年 | 27篇 |
1988年 | 26篇 |
1987年 | 20篇 |
1986年 | 18篇 |
1985年 | 32篇 |
1984年 | 20篇 |
1983年 | 23篇 |
1982年 | 24篇 |
1981年 | 19篇 |
1979年 | 19篇 |
1977年 | 15篇 |
1976年 | 11篇 |
1975年 | 12篇 |
1974年 | 19篇 |
1968年 | 12篇 |
1967年 | 10篇 |
排序方式: 共有6121条查询结果,搜索用时 15 毫秒
991.
992.
Serge A. Mitelman Monte S. Buchsbaum Bradley T. Christian Brian M. Merrill Bradley R. Buchsbaum Jogeshwar Mukherjee 《The world journal of biological psychiatry》2020,21(5):368-382
AbstractObjectives: Overlapping decreases in extrastriatal dopamine D2/D3-receptor availability and glucose metabolism have been reported in subjects with schizophrenia. It remains unknown whether these findings are physiologically related or coincidental.Methods: To ascertain this, we used two consecutive 18F-fluorodeoxyglucose and 18F-fallypride positron emission tomography scans in 19 healthy and 25 unmedicated schizophrenia subjects. Matrices of correlations between 18F-fluorodeoxyglucose uptake and 18F-fallypride binding in voxels at the same xyz location and AFNI-generated regions of interest were evaluated in both diagnostic groups.Results: 18F-fluorodeoxyglucose uptake and 18F-fallypride binding potential were predominantly positively correlated across the striatal and extrastriatal grey matter in both healthy and schizophrenia subjects. In comparison to healthy subjects, significantly weaker correlations in subjects with schizophrenia were confirmed in the right cingulate gyrus and thalamus, including the mediodorsal, lateral dorsal, anterior, and midline nuclei. Schizophrenia subjects showed decreased D2/D3-receptor availability in the hypothalamus, mamillary bodies, thalamus and several thalamic nuclei, and increased glucose uptake in three lobules of the cerebellar vermis.Conclusions: Dopaminergic system may be involved in modulation of grey matter metabolism and neurometabolic coupling in both healthy human brain and psychopathology. Hyperdopaminergic state in untreated schizophrenia may at least partly account for the corresponding decreases in grey matter metabolism. 相似文献
993.
Thomas Blanc Nicolas Goudin Mohamad Zaidan Meriem Garfa Traore Frank Bienaime Lisa Turinsky Serge Garbay Clément Nguyen Martine Burtin Gérard Friedlander Fabiola Terzi Marco Pontoglio 《Kidney international》2021,99(3):632-645
- Download : Download high-res image (325KB)
- Download : Download full-size image
994.
Recellularizing of human acellular dermal matrices imaged by high‐definition optical coherence tomography
下载免费PDF全文
![点击此处可从《Experimental dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Marc A. L. M. Boone Jean Pierre Draye Gunther Verween Annalisa Aiti Jean‐Paul Pirnay Gilbert Verbeken Daniel De Vos Thomas Rose Serge Jennes Gregor B. E. Jemec Veronique del Marmol 《Experimental dermatology》2015,24(5):349-354
High‐definition optical coherence tomography (HD‐OCT) permits real‐time 3D imaging of the impact of selected agents on human skin allografts. The real‐time 3D HD‐OCT assessment of (i) the impact on morphological and cellular characteristics of the processing of human acellular dermal matrices (HADMs) and (ii) repopulation of HADMs in vitro by human fibroblasts and remodelling of the extracellular matrix by these cells. Four different skin decellularization methods, Dispase II/Triton X‐100, Dispase II/SDS (sodium dodecyl sulphate), NaCl/Triton X‐100 and NaCl/SDS, were analysed by HD‐OCT. HD‐OCT features of epidermal removal, dermo‐epidermal junction (DEJ) integrity, cellularity and dermal architecture were correlated with reflectance confocal microscopy (RCM), histopathology and immunohistochemistry. Human adult dermal fibroblasts were in vitro seeded on the NaCl/Triton X‐100 processed HADMs, cultured up to 19 days and evaluated by HD‐OCT in comparison with MTT proliferation test and histology. Epidermis was effectively removed by all treatments. DEJ was best preserved after NaCl/Triton X‐100 treatment. Dispase II/SDS treatment seemed to remove all cellular debris in comparison with NaCl/Triton X‐100 but disturbed the DEJ severely. The dermal micro‐architectural structure and vascular spaces of (sub)papillary dermis were best preserved with the NaCl/Triton X‐100. The impact on the 3D structure and vascular holes was detrimental with Dispase II/SDS. Elastic fibre fragmentation was only observed after Dispase II incubation. HD‐OCT showed that NaCl/Triton X‐100 processed matrices permitted in vitro repopulation by human dermal fibroblasts (confirmed by MTT test and histology) and underwent remodelling upon increasing incubation time. Care must be taken in choosing the appropriate processing steps to maintain selected properties of the extracellular matrix in HADMs. Processing HADMs with NaCl/Triton X‐100 permits in vitro the proliferation and remodelling activity of human dermal fibroblasts. HD‐OCT provides unique real‐time and non‐invasive 3D imaging of tissue‐engineered skin constructs and complementary morphological and cytological information. 相似文献
995.
Murat Yücel Erin Oldenhof Serge H. Ahmed David Belin Joel Billieux Henrietta Bowden‐Jones Adrian Carter Samuel R. Chamberlain Luke Clark Jason Connor Mark Daglish Geert Dom Pinhas Dannon Theodora Duka Maria Jose Fernandez‐Serrano Matt Field Ingmar Franken Rita Z. Goldstein Raul Gonzalez Anna E. Goudriaan Jon E. Grant Matthew J. Gullo Robert Hester David C. Hodgins Bernard Le Foll Rico S. C. Lee Anne Lingford‐Hughes Valentina Lorenzetti Scott J. Moeller Marcus R. Munaf Brian Odlaug Marc N. Potenza Rebecca Segrave Zsuzsika Sjoerds Nadia Solowij Wim van den Brink Ruth J. van Holst Valerie Voon Reinout Wiers Leonardo F. Fontenelle Antonio Verdejo‐Garcia 《Addiction (Abingdon, England)》2019,114(6):1095-1109
996.
Eric Therasse Véronique Caty Patrick Gilbert Marie-France Giroux Pierre Perreault Louis Bouchard Vincent L. Oliva Jacques Lespérance Jean Ethier Georges Ouellet Martin Francoeur Serge Cournoyer Gilles Soulez 《Journal of vascular and interventional radiology : JVIR》2021,32(3):350-359.e2
PurposeTo assess whether angioplasty of hemodialysis access (HA) stenosis with a drug-coated balloon (DCB) would prevent restenosis in comparison with plain-balloon percutaneous transluminal angioplasty (PTA).Materials and MethodsThis prospective randomized clinical trial enrolled 120 patients with dysfunctional arteriovenous fistulae (n = 109) and grafts (n = 11), due to a ≥50% stenosis between March 2014 and April 2018. All patients underwent high-pressure balloon angioplasty and were then randomized to either DCB (n = 60) or PTA (n = 60). Patients were followed-up for 1 year, and angiography was performed 6 months after angioplasty. The primary endpoint was the late lumen loss (LLL) at 6 months. Secondary endpoints included other angiographic parameters at 6 months and HA failures, adverse event, and mortality at 12 months. Continuous variables were compared with a Student t-test, and Kaplan-Meier curves were used for freedom from HA failure and for mortality.ResultsLLL in the DCB and in the PTA group were 0.64 mm ± 1.20 and 1.13 mm ± 1.51, respectively (P = .082, adjusted P = .0498). DCB was associated with lower percentage stenosis (54.2% ± 19.3 vs 61.7% ± 18.2; P = .047) and binary restenosis ≥50% (56.5% vs 81.1%; P = .009) than PTA. The number of HA failures after 12 months was lower for DCB than for PTA (45% vs 66.7%; P = .017). Mortality at 12 months was 10% and 8.3% in the DCB and PTA groups, respectively (P = .75).ConclusionsDespite LLL improvement that failed to reach statistical significance, this study demonstrated decreased incidence and severity of restenosis with DCB compared with PTA to treat dysfunctional HA. 相似文献
997.
998.
999.
1000.
Siwar Ayouni Khira Sdiri-Loulizi Alexis de Rougemont Marie Estienney Katia Ambert-Balay Serge Aho Sabeur Hamami Mahjoub Aouni Mohamed Neji-Guediche Pierre Pothier Ga?l Belliot 《Emerging infectious diseases》2015,21(11):2055-2058
To determine whether rotavirus infections are linked to secretor status, we studied samples from children in Tunisia with gastroenteritis. We phenotyped saliva for human blood group antigens and tested feces for rotavirus. Rotavirus was detected in 32/114 patients. Secretor genotyping showed that P[8] rotavirus infected secretors and nonsecretors, and infection correlated with presence of Lewis antigen. 相似文献