周边国家和地区中医药国际教育需求分析

通过对中医药国际教育发展的现状、我国周边国家和地区中医药国际教育需求进行梳理、分析,提出适用于我国周边国家和地区留学生的中医药国际教育发展策略,为进一步稳固周边国家和地区生源,逐步开发高层次教育市场提供参考。     

The expressions and significance of α-, β-catenins and cyclin D1 in breast cancers

Objective  To study the relationship between expressions of α-, β-catenins and cyclin D1 and the occurrence, infiltration and metastasis of breast cancer. Methods  High sensitive S-P immunohistochemical method was used to detect the protein expressions of α-, β-catenins and cyclin D1 in the 60 cases of breast cancer tissues. Results  Abnormal immunoreactivities of α-and β-catenins were observed in 37 (61.7%) and 42 (70%) cases of breast cancer tissues, respectively. There were 28 cases (46.7%) who showed cyclin D1 overexpression. The abnormal expression rates of α-and β-catenins in infiltrating lobular carcinoma (ILC) were significantly higher than those in infiltrating ductal carcinoma (IDC) (P < 0.05), but they had no relations to the extent of differentiation and lymphatic metastasis of breast cancer (P > 0.05). The overexpression rate of cyclin D1 was correlated with tumor stage and lymphatic metastasis of breast cancer (P < 0.05), but not with histological type and the extent of differentiation (P > 0.05). Cyclin D1 overexpression was observed in 57.1% (24/42) of these cases that showed abnormal staining of β-catenin, but only observed in 22.2% (4/18) of these cases with normal membranous staining of β-catenin. There was a significantly positive correlation between the abnormal expression of β-catenin and overexpression of cyclin D1 (r _s = 0.321, P < 0.05). Conclusion  The abnormal expression of β-catenin may play an important role in the genesis of breast cancer by triggering cyclin D1 overexpression in breast cancer. The abnormal expressions of α-and β-catenins are not a key factor in malignant cell metastasis in breast cancer, but may also involve in the progress.     

乳腺癌根治术中保留肋间臂神经25例应用体会

目的探讨保留肋间臂神经在乳腺癌根治术中的必要性、可行性及适应症。方法随访分析45例乳癌根治术中保留肋间臂神经25例、未保留肋间臂神经20例术后对上臂内侧、腋部感觉功能的影响及手术操作体会。结果随访12-24个月,平均20个月,保留肋间臂神经25例中21例（84%）术后患侧上臂内侧及腋部感觉正常,4例（16%）感觉异常;未保留肋间臂神经20例均有感觉异常。手术时间：保留组较不保留组增加10-15min,平均12min。两组患者均未发现肿瘤局部转移、复发。结论保留肋间臂神经可明显减少乳腺癌根治术后患侧上臂内侧及腋部感觉异常的发生,可显著提高患者术后生存质量,且无明显增加手术时间,也未发现肿瘤局部转移、复发。对无腋窝淋巴结转移患者及腋窝淋巴结有转移但无明显粘连患者是可行的。     

The characteristics of impaired fasting glucose associated with obesity and dyslipidaemia in a Chinese population

Background  

Different populations have diverse patterns of relationships between Impaired Fasting Glucose (IFG) and obesity and lipid markers, it is important to investigate the characteristics of associations between IFG and other related risk factors including body mass index (BMI), waist circumstance (WC), serum lipids and blood pressure (BP) in a Chinese population.     

~(99m)Tc-HMPAO脑局部血流断层显像对体外反搏治疗脑梗塞疗效的初步观察

观察17例脑梗塞患者,体外反搏前后脑局部血流断层显像(脑SPECT的改变,14例有效,3例无效,有效率为82.4％P相似文献   

gyrA和 parC基因突变与解脲支原体喹诺酮类药物耐药相关性研究

目的探讨解脲支原体gyrA和parC基因喹诺酮耐药决定区(QRDR)突变与喹诺酮类药物耐药的相关性。方法用支原体培养、鉴定和药敏一体化试剂盒分离获得42株解脲支原体并检测对3种喹诺酮类药物的耐药性,同时PCR法扩增临床分离株的gyrA和parC基因喹诺酮耐药决定区并进行测序分析。结果对3种喹诺酮均敏感1株,41株至少对1种药物呈现不同程度耐药。gyrA和parC基因喹诺酮耐药决定区测序发现上述敏感株和1株耐药株不发生突变,其余40株耐药株gyrA和parC基因发生D112E和(或)S83L突变。结论 3种喹诺酮类药物耐药均较严重,已不适合作为临床推荐用药,解脲支原体gyrA和parC基因喹诺酮耐药决定区突变与耐药密切相关。     

西黄胶囊联合盐酸吗啡缓释片治疗中晚期肺癌疼痛临床观察

目的观察西黄胶囊联合盐酸吗啡缓释片治疗中晚期肺癌疼痛的效果。方法 97例中晚期肺癌患者随机分为治疗组和对照组,治疗组给予盐酸吗啡缓释片和西黄胶囊;对照组给予盐酸吗啡缓释片,治疗2周后评价疗效,观察患者疼痛改善及生活质量提高情况。结果治疗组疼痛明显改善,生活质量明显提高。结论西黄胶囊联合盐酸吗啡缓释片治疗癌痛,能显著改善症状,提高生活质量。     

中西药临床药师科普干预在儿童住院患者中的效果研究

目的：明确临床药师科普干预的重要性,探索儿科临床药师有效进行科普干预的方法,从而提高患者用药依从性,提升临床疗效,减少再住院率。方法：将儿科社区获得性肺炎住院患者随机分为对照组和科普干预组各50例,其中科普干预组又进一步分为西药临床药师科普干预组25例和中西药临床药师联合科普干预组25例,分别进行临床疗效、用药依从性、科普知识知晓率、再住院率评价。结果：在提高临床疗效方面,科普干预组与对照组比较差异均有统计学意义,西药科普干预组和中西药联合科普干预组比较差异无统计学意义。在提高患者用药依从性方面,中西药联合科普1次即有明显效果,单纯西药科普2次有明显效果。随访对照组半年内有2例患儿因肺炎再次入院,科普组无1例患儿因肺炎再次入院。结论：患儿的安全用药教育刻不容缓,临床药师的科普宣教对提升患者用药依从性、提高临床疗效方面成效显著。