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排序方式: 共有834条查询结果,搜索用时 15 毫秒
831.
Kentaro Nobutani Yohei Shimono Midori Yoshida Kiyohito Mizutani Akihiro Minami Seishi Kono Toru Mukohara Takashi Yamasaki Tomoo Itoh Shintaro Takao Hironobu Minami Takeshi Azuma Yoshimi Takai 《Genes to cells : devoted to molecular & cellular mechanisms》2014,19(2):141-152
Previous studies using cultured cells showed that primary cilia are present in quiescent cells, but are absent in proliferating cells. We studied here the relationship between the presence or absence of primary cilia and the cell cycle arrest of normal epithelial cells and cancer cells in the human normal breast and breast cancer tissues. In normal breast tissues, although most epithelial cells were nonproliferating as estimated by the immunofluorescence staining of the proliferation marker Ki‐67, primary cilia were present only in 20–40% of the epithelial cells. In breast cancer tissues, primary cilia were not observed in any of the breast cancer cells. Furthermore, primary cilia were hardly observed in the nonproliferating cancer cells in the orthotopic and metastatic human breast cancer xenograft tumors in mice. These results indicate that the absence of primary cilia does not necessarily represent the proliferating phases of normal epithelial cells and cancer cells. 相似文献
832.
833.
Yoshiyuki Onishi Haruka Hisato Seishi Maeda Yusuke Minato Sachi Kuwahara-Otani Hideshi Yagi 《Journal of anatomy》2021,239(1):101-110
Vibration is detected by mechanoreceptors, including Pacinian corpuscles (PCs), which are widely distributed in the human body including the adventitia of large blood vessels. Although the distribution of PCs around large limb vessels has been previously reported, there remains no consensus on their distribution in the adventitia of the human deep blood vessels in the upper arm. In addition, the physiological functions of PCs located around the deep limb blood vessels remain largely unknown. This study aimed to elucidate detailed anatomical features and physiological function of lamellar sensory corpuscles structurally identified as PCs using the immunohistochemical methods around the deep vessels in the upper arm. We identified PCs in the connective tissue adjacent to the deep vessels in the upper arm using histological analysis and confirmed that PCs are located in the vascular sheath of the artery and its accompanying vein as well as in the connective tissue surrounding the vascular sheath and nerves. PCs were densely distributed on the distal side of deep vessels near the elbow. We also examined the relationship between vascular sound and pulsating sensation to evaluate the PCs functions around deep arteries and veins and found that the vascular sound made by pressing the brachial arteries in the upper arm was associated with the pulsating sensation of the examinee. Our results suggest that PCs, around deep vessels, function as bathyesthesia sensors by detecting vibration from blood vessels. 相似文献
834.
Takashi Yanagihara Masashi Shimohira Masanori Inoue Keita Nakayama Masashi Tamura Seishi Nakatsuka Hideo Hattori Katsura Emoto Keisuke Yokota Katsuhiro Okuda Ryoichi Nakanishi Kaoru Kaseda Chihaya Maeda Keisuke Asakura Akio Hiwatashi 《Radiology Case Reports》2022,17(6):2101
Coil embolization is widely performed for pulmonary arteriovenous malformations (PAVMs). We describe herein 2 cases of hemoptysis during long-term follow-up after coil embolization for PAVMs. For both cases, lobectomy was performed and histopathological examinations revealed chronic inflammation and bronchial epithelium extension into the sac of the PAVM. In addition, we performed a systematic review of previous reports of hemoptysis after embolization for PAVMs. 相似文献