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Arianne MJ Elissen Dorijn FL Hertroijs Nicolaas C Schaper Hubertus JM Vrijhoef Dirk Ruwaard 《International journal of integrated care》2016,16(2)
Background:This article presents the design of PROFILe, a study
investigating which (bio)medical and non-(bio)medical patient characteristics
should guide more tailored chronic care. Based on this insight, the project aims
to develop and validate ‘patient profiles’ that can be used in
practice to determine optimal treatment strategies for subgroups of chronically
ill with similar healthcare needs and preferences.Methods/Design:PROFILe is a practice-based research comprising four
phases. The project focuses on patients with type 2 diabetes. During the first
study phase, patient profiles are drafted based on a systematic literature
research, latent class growth modeling, and expert collaboration. In phase 2,
the profiles are validated from a clinical, patient-related and statistical
perspective. Phase 3 involves a discrete choice experiment to gain insight into
the patient preferences that exist per profile. In phase 4, the results from all
analyses are integrated and recommendations formulated on which patient
characteristics should guide tailored chronic care.Discussion:PROFILe is an innovative study which uses a uniquely
holistic approach to assess the healthcare needs and preferences of chronically
ill. The patient profiles resulting from this project must be tested in practice
to investigate the effects of tailored management on patient experience,
population health and costs. 相似文献
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Peter A Jarzyna Lisette H Deddens Benjamin H Kann Sarayu Ramachandran Claudia Calcagno Wei Chen Anita Gianella Rick M Dijkhuizen Arjan W Griffioen Zahi A Fayad Willem JM Mulder 《Neoplasia (New York, N.Y.)》2012,14(10):964-973
One of the challenges of tailored antiangiogenic therapy is the ability to adequately monitor the angiogenic activity of a malignancy in response to treatment. The αvβ3 integrin, highly overexpressed on newly formed tumor vessels, has been successfully used as a target for Arg-Gly-Asp (RGD)-functionalized nanoparticle contrast agents. In the present study, an RGD-functionalized nanocarrier was used to image ongoing angiogenesis in two different xenograft tumor models with varying intensities of angiogenesis (LS174T > EW7). To that end, iron oxide nanocrystals were included in the core of the nanoparticles to provide contrast for T2*-weighted magnetic resonance imaging (MRI), whereas the fluorophore Cy7 was attached to the surface to enable near-infrared fluorescence (NIRF) imaging. The mouse tumor models were used to test the potential of the nanoparticle probe in combination with dual modality imaging for in vivo detection of tumor angiogenesis. Pre-contrast and post-contrast images (4 hours) were acquired at a 9.4-T MRI system and revealed significant differences in the nanoparticle accumulation patterns between the two tumor models. In the case of the highly vascularized LS174T tumors, the accumulation was more confined to the periphery of the tumors, where angiogenesis is predominantly occurring. NIRF imaging revealed significant differences in accumulation kinetics between the models. In conclusion, this technology can serve as an in vivo biomarker for antiangiogenesis treatment and angiogenesis phenotyping. 相似文献
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Background
Women with Down syndrome very rarely develop breast cancer even though they now live to an age when it normally occurs. This may be related to the fact that Down syndrome persons have an additional copy of chromosome 21 where the gene that codes for the antiangiogenic protein Endostatin is located. Can this information lead to a primary antiangiogenic therapy for early stage breast cancer that indefinitely prolongs remission? A key question that arises is when is the initial angiogenic switch thrown in micrometastases? We have conjectured that avascular micrometastases are dormant and relatively stable if undisturbed but that for some patients angiogenesis is precipitated by surgery. We also proposed that angiogenesis of micrometastases very rarely occurs before surgical removal of the primary tumor. If that is so, it seems possible that we could suggest a primary antiangiogenic therapy but the problem then arises that starting a therapy before surgery would interfere with wound healing. 相似文献998.
HG NIE JQ CAI MJ WEI ZG SONG WB JIN JM LI XS YU BZ SUN 《中国药理通讯》2006,23(2):18-19
In order to clarify which teaching form encourages student' s self-motivation learning ability better, we did a comparison experiment between problem-based learning (PBL)and lecture-based learning (LBL) in a 3rd year course in basic pharmacology. Of 224 students who participated (124 PBL, 100 LBL) in pharmacology course, the experimental group was divided into 6 teams(20 - 21 students for each team with one tutor)using PBL method with 7 clinical cases discussion while o.ther 100 students held in the same lecture-based format as the traditional LBL course as a control group. In 224 students, 50.4% using PBL method self-directed learning ability had increased compared with 35.3% in LBL teaching mode. The test score indicated that students using LBL teaching method scored overall higher than those using PBL mode, especially at objective items, this result was significant.. iy different(P =0.009). However, as far as subjective items are concerned, students accepted PBL mode showed their superior advantages over the LBL ones. Similarly, the result was significantly different( P =0.001 ). On the whole, PBL method supported by appropriate technology and teachers, has allowed our students to analyze authentic situations as a doctor status and the active learning ability by self-motivation study will be undoubtedly beneficial for their becoming life-long learners and excellent doctors in the future. 相似文献
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