Tethered cord syndrome in adulthood

OBJECTIVE/BACKGROUND: The standard treatment for tethered cord syndrome (operative vs nonoperative management) that presents in adulthood remains controversial. A comparative study of tethered cord syndrome in adulthood is needed. DESIGN: A retrospective chart-based analysis. METHODS: Patients admitted to Gulhane Military Medical Academy Department of Neurosurgery for management of caudal spinal cord tethering from June 1999 through December 2006 (N = 22). RESULTS: Conus level was normal in 1 patient with split cord malformation and dermal sinus. Tight terminal filum was found in 21 patients, including postrepair myelomeningocele tethered cord in 4, lipomyelomeningocele/meningocele in 8, split cord malformation in 3, dermal sinus in 7, and syringomyelia in 3. The most common complaints were back pain (15 patients, 68.1%), bladder dysfunction (8, 36.3%), fecal incontinence (2, 9.09%), and leg pain (7, 31.8%). One patient had hydrocephalus (4.5%). Ten of 22 patients underwent surgery; 8 of 10 patients had detethering; and 12 patients refused surgery. Postoperative cerebrospinal fluid leakage requiring reinforcement sutures occurred in 1 patient. There were no infectious complications. Neurologic status and outcomes were compared with preoperative findings. CONCLUSIONS: Some patients refuse surgery despite severe neurologic disturbances. Neurosurgeons should fully explain the risks and benefits of surgery for tethered cord to the patient and family. A much larger and prospective randomized series is needed to determine the effects of operative vs nonoperative management of tethered cord syndrome in adulthood.     

肺部超声在支气管肺泡灌洗治疗新生儿肺不张效果评估中的应用价值

目的 探讨肺部超声动态评估支气管肺泡灌洗(BLA)治疗新生儿肺不张的效果.方法 收集我院新生儿重症监护室收治的60例肺不张患儿,经肺部超声标记肺不张的部位后行纤维支气管镜下BLA治疗.每次治疗后均行肺部超声检查观察肺不张恢复程度以决定是否继续进行灌洗.记录肺部啰音消失时间、机械通气时间及抗生素使用时间;比较治疗前及治疗...     

The CSF creatine kinase-BB isoenzyme activity in experimental lumbar spinal stenosis model

STUDY DESIGN: An investigation of creatine kinase (CK)-BB isoenzyme activity in cerebrospinal fluid (CSF) of the rabbits after experimentally induced spinal stenosis. OBJECTIVES: To create a lumbar spinal stenosis (LSS) model at conus medullaris level without laminectomy in rabbits and to investigate the importance of CK-BB isoenzyme activity in CSF associated with electrophysiologic and histopathologic changes in the spinal cord. SUMMARY OF BACKGROUND DATA: LSS is a disorder characterized by leg pain and difficulty of walking. Narrowing of the spinal canal and compression on the spinal cord and nerves are the main features of spinal stenosis. METHODS: Fifteen male albino rabbits were used in this study. A reproducible, subacute LSS model was created in all rabbits, and CSF CK-BB activity was measured above and below the stenosis level. The electrophysiologic evaluation and the histopathologic examination of the conus medullaris were also performed in each rabbit. RESULTS: The CK-BB activity was 71.5% in CSF samples that were obtained below the stenosis. The activity was 44.5% in samples obtained above the stenosis and 43.6% in nonstenotic rabbits. In the electrophysiologic studies, the mean amplitudes were decreased and the latency values were lengthened in all ascending and descending nerve potentials at both sides of the stenosis. The number of the neural cells was decreased and imperception of the nucleolus of neural cells and vacuolar degeneration were observed in the histopathologic examination of conus medullaris. CONCLUSIONS: The activity of CK-BB isoenzyme was increased in CSF of which the circulation was disturbed as a result of neural ischemia, which was accepted in the pathophysiology of LSS.     

Head injuries due to landmines

Summary Background. Landmine explosions cause most of the war injuries in the battlefield and pose a substantial public health risk. Although the lower limbs are usually affected, head injuries also occur. The aim of this study is to describe the types of head injuries caused by the explosion of landmines and the management of the victims. Patients and method. Fifteen patients who sustained a head injury due to a landmine explosion were treated in the Department of Neurosurgery between 2000 and 2006. The average age of the patients was 22.5 (range between 20 and 33). The Glasgow Coma Scale (GCS) score ranged between 3 and 15 and was 8 or less in 4. Shrapnel, stone and earth were the wounding agents. Four patients underwent neurosurgical treatment and 11, apart from simple scalp closure, had conservative treatment. Ten patients had associated lesions in the other parts of the body including thorax, upper and lower limbs, and the abdomen. Findings. Two patients died. At the time of admission, one had a GCS score of 3 and the other a score of 4. Infection was observed among 4 patients and a cerebrospinal fluid (CSF) fistula in 1 patient. Conclusion. Landmines occasionally cause head injuries. Surgical intervention is seldom required and survival is likely unless the patient is in deep coma. Multidisciplinary approaches are required in case there are associated lesions in the other parts of the body.     

Surgical management and outcome of large orbitocranial osteomas

OBJECT: The goal of this study is to review the surgical management and outcome of patients who were treated for large orbitocranial osteomas at Gulhane Military Medical Academy over a period of 7 years. METHODS: Twenty-one patients with large orbitocranial osteomas were evaluated retrospectively. All patients were male and between 19 and 25 years old. Surgery was performed in all patients. The main surgical procedure was resection of the osteoma using orbitotomy and/or craniotomy followed by orbital reconstruction and cranioplasty. Cranioplasty was performed in 16 patients, using methyl methacrylate in 5 patients (31%) and porous polyethylene in 11 patients (69%). Thin, flexible, porous polyethylene was preferred for orbital reconstruction in 10 patients. The cranioplasty materials were attached to the intact bone using miniplates. RESULTS: There were no severe postoperative complications. Mild transient periorbital ecchymosis was noted in 19 patients. The mean follow-up period was 11.7 months (range 9-24 months) after surgery. No tumor regrowth was observed in any patient at the end of the follow-up period. CONCLUSIONS: Large osteomas of the orbitocranial region must be resected for cosmetic and functional reasons. Selection and planning of the surgical technique should be based on the direction of the tumor growth and on the size of the tumor and the structures that are compressed by the tumor.     

Gallbladder bile: an experimental study in dogs using MR imaging and proton MR spectroscopy

Magnetic resonance (MR) imaging, proton MR spectroscopy, and biochemical analysis were performed to investigate MR signal intensity (SI) differences between concentrated and dilute gallbladder bile of seven fasting and five sincalide-treated dogs. MR images revealed high SI from bile of fasting dogs and low to medium SI in sincalide-treated dogs when spin-echo (SE) pulse sequences with repetition rates of 0.5 and 2.0 sec were used. Proton MR spectra were similar for fasting and sincalide-treated dogs. In fasting dogs, water content in the bile was slightly lower, and cholesterol, phospholipid, and bile acid concentrations were higher. More than 90% of proton signals in all Fourier transform free induction decay spectra emanated from water molecules, and no lipid proton resonances were detected in Fourier transform SE spectra after tau delays of 7 msec. These results indicate that the differences in SI are caused by alterations in relaxation times of water protons, possibly resulting from the interactions of water protons and macromolecules.     

Perirectal inflammatory disease: CT findings

The findings on computed tomographic (CT) scans were reviewed in 42 patients with perirectal inflammatory disease and suspected perirectal abscesses. CT was reliable for use in distinguishing perirectal abscesses from cellulitis and in localizing both supralevator and infralevator abscesses. CT allowed correct diagnosis of 13 surgically proved perirectal abscesses in ten patients, including three with residual abscesses after surgical drainage. In three patients with supralevator abscesses, the abscess was missed on initial surgical exploration. In patients without abscesses, CT was helpful in evaluating the extent of perirectal inflammation; however, it was not possible to determine its cause. The anatomy on CT scans of the pararectal spaces is reviewed, with emphasis on useful anatomic landmarks in the axial plane for distinguishing supralevator from infralevator abscesses.     

Magnetic resonance imaging and spectroscopy of hepatic iron overload

Experimental animals that had been given excess iron in their diet were studied by magnetic resonance (MR) imaging in vivo and by magnetic resonance (MR) spectroscopy in vitro. Hepatic iron overload in patients with transfusional iron excess was studied by MR imaging, and isolated iron protein fractions were studied in vitro by MR spectroscopy. The spin echo image intensity of livers with iron overload was decreased because of the extreme decreases in T2 compared with normal; T1 was decreased only moderately. The relaxation rates 1/T2 and 1/T1 both showed a linear relationship to hepatic iron levels. Ferritin solutions showed moderate decreases in T2 and mild decreases in T1. The T2 relaxivity of ferritin, which is due to the iron core rather than the apoferritin protein shell, does not appear sufficient to account for the extreme decrease in T2 observed in hepatic iron overload. Low molecular weight cytosol iron is present in lower concentrations than ferritin but potentially has much greater relaxivity and may contribute to the MR findings. These techniques may be useful in other studies of iron metabolism.