全文获取类型
收费全文 | 706篇 |
免费 | 47篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 128篇 |
妇产科学 | 57篇 |
基础医学 | 111篇 |
口腔科学 | 14篇 |
临床医学 | 51篇 |
内科学 | 100篇 |
皮肤病学 | 16篇 |
神经病学 | 10篇 |
特种医学 | 74篇 |
外科学 | 48篇 |
综合类 | 9篇 |
预防医学 | 19篇 |
眼科学 | 57篇 |
药学 | 22篇 |
肿瘤学 | 37篇 |
出版年
2022年 | 2篇 |
2021年 | 3篇 |
2020年 | 6篇 |
2019年 | 10篇 |
2018年 | 14篇 |
2017年 | 12篇 |
2016年 | 13篇 |
2015年 | 28篇 |
2014年 | 42篇 |
2013年 | 25篇 |
2012年 | 37篇 |
2011年 | 25篇 |
2010年 | 19篇 |
2009年 | 32篇 |
2008年 | 29篇 |
2007年 | 39篇 |
2006年 | 51篇 |
2005年 | 35篇 |
2004年 | 24篇 |
2003年 | 18篇 |
2002年 | 24篇 |
2001年 | 29篇 |
2000年 | 16篇 |
1999年 | 7篇 |
1998年 | 22篇 |
1997年 | 40篇 |
1996年 | 30篇 |
1995年 | 15篇 |
1994年 | 25篇 |
1993年 | 14篇 |
1992年 | 8篇 |
1991年 | 8篇 |
1990年 | 4篇 |
1989年 | 9篇 |
1988年 | 6篇 |
1987年 | 3篇 |
1986年 | 3篇 |
1985年 | 5篇 |
1984年 | 2篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1980年 | 6篇 |
1976年 | 5篇 |
排序方式: 共有755条查询结果,搜索用时 0 毫秒
751.
Jane E Norman Andrew Shennan Phillip Bennett Steven Thornton Stephen Robson Neil Marlow John Norrie Stavros Petrou Neil Sebire Tina Lavender Sonia Whyte 《BMC pregnancy and childbirth》2012,12(1):1-9
Background
Maternal, neonatal and child health outcomes are worse in families from black and ethnic minority groups and disadvantaged backgrounds. There is little evidence on whether lay support improves maternal and infant outcomes among women with complex social needs within a disadvantaged multi-ethnic population in the United Kingdom (UK).Method/Design
The aim of this study is to evaluate a lay Pregnancy Outreach Worker (POW) service for nulliparous women identified as having social risk within a maternity service that is systematically assessing social risks alongside the usual obstetric and medical risks. The study design is a randomised controlled trial (RCT) in nulliparous women assessed as having social risk comparing standard maternity care with the addition of referral to the POW support service. The POWs work alongside community midwifery teams and offer individualised support to women to encourage engagement with services (health and social care) from randomisation (before 28 weeks gestation) until 6 weeks after birth. The primary outcomes have been chosen on the basis that they are linked to maternal and infant health. The two primary outcomes are engagement with antenatal care, assessed by the number of antenatal visits; and maternal depression, assessed using the Edinburgh Postnatal Depression Scale at 8-12 weeks after birth. Secondary outcomes include maternal and neonatal morbidity and mortality, routine child health assessments, including immunisation uptake and breastfeeding at 6 weeks. Other psychological outcomes (self efficacy) and mother-to-infant bonding will also be collected using validated tools. A sample size of 1316 will provide 90% power (at the 5% significance level) to detect increased engagement with antenatal services of 1.5 visits and a reduction of 1.5 in the average EPDS score for women with two or more social risk factors, with power in excess of this for women with any social risk factor. Analysis will be by intention to treat. Qualitative research will explore the POWs' daily work in context. This will complement the findings of the RCT through a triangulation of quantitative and qualitative data on the process of the intervention, and identify other contextual factors that affect the implementation of the intervention.Discussion
The trial will provide high quality evidence as to whether or not lay support (POW) offered to women identified with social risk factors improves engagement with maternity services and reduces numbers of women with depression.MREC number
10/H1207/23Trial registration number
ISRCTN: ISRCTN35027323 相似文献752.
M. A. Weber R. A. Risdon M. Malone P. G. Duffy N. J. Sebire 《Fetal and pediatric pathology》2005,24(4):267-275
We present a male infant with antenatally detected, focal, unilateral apparently isolated renal cystic disease with morphological features of renal involvement in tuberous sclerosis. Only one previous case with similar presentation has been described. Most affected children present with either diffuse bilateral renal cystic disease or extrarenal manifestations. The major genes involved in tuberous sclerosis are now well described, and early onset of severe renal cystic disease in affected children often is related to the presence of a contiguous gene deletion syndrome involving TSC2 and PKD1 on chromosome 16. 相似文献
753.
This report illustrates a rare genetic disorder, Currarino syndrome, in association with an unusual malignant transformation to a peripheral primitive neuroectodermal tumour within a sacral teratoma. The triad of features consists of a presacral mass, partial sacral agenesis and anorectal anomalies. The most common presentation is constipation. In this case there was a history of constipation, teratomas and spinal abnormalities in many of the family members over three generations. Detailed family history taken at time of initial presentation may have prevented delay in diagnosis and averted the need for intensive treatment, which may well cause late sequelae. 相似文献
754.
DA Scott ML Kraft R Carmi A Ramesh K Elbedour Y Yairi C. R. Srikumari Srisailapathy SS Rosengren AF Markham RF Mueller NJ Lench G Van Camp RJH Smith VC Sheffield 《Human mutation》1998,11(5):387-394
Mutations in the Cx26 gene have been shown to cause autosomal recessive nonsyndromic hearing loss (ARNSHL) at the DFNB1 locus on chromosome 13q12. Using direct sequencing, we screened the Cx26 coding region of affected and nonaffected members from seven ARNSHL families either linked to the DFNB1 locus or in which the ARNSHL phenotype cosegregated with markers from chromosome 13q12. Cx26 mutations were found in six of the seven families and included two previously described mutations (W24X and W77X) and two novel Cx26 mutations: a single base pair deletion of nucleotide 35 resulting in a frameshift and a C-to-T substitution at nucleotide 370 resulting in a premature stop codon (Q124X). We have developed and optimized allele-specific PCR primers for each of the four mutations to rapidly determine carrier and noncarrier status within families. We also have developed a single stranded conformational polymorphism (SSCP) assay which covers the entire Cx26 coding region. This assay can be used to screen individuals with nonsyndromic hearing loss for mutations in the CX26 gene. Hum Mutat 11:387–394, 1998. © 1998 Wiley-Liss, Inc. 相似文献
755.