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排序方式: 共有458条查询结果,搜索用时 78 毫秒
121.
Holzmann K Kohlhammer H Schwaenen C Wessendorf S Kestler HA Schwoerer A Rau B Radlwimmer B Döhner H Lichter P Gress T Bentz M 《Cancer research》2004,64(13):4428-4433
Genomic analyses aimed at the detection of high-level DNA amplifications were performed on 13 widely used pancreatic cancer cell lines and 6 pancreatic tumor specimens. For these analyses, array-based comparative genomic hybridization (Matrix-CGH) onto dedicated microarrays was used. In comparison with chromosomal CGH (eight amplifications), a >3-fold number of DNA amplifications was detected (n = 29). The most frequent amplifications mapped to 7p12.3 (three pancreatic cancer cell lines and three pancreatic tumor specimens), 8q24 (four pancreatic cancer cell lines and one pancreatic tumor specimen), 11q13 (three pancreatic cancer cell lines and three pancreatic tumor specimens), and 20q13 (four pancreatic cancer cell lines and three pancreatic tumor specimens). Genes contained in the consensus regions were MYC (8q24), EGFR (7p12.3), and FGF3 (11q13). In six of seven pancreatic cancer cell lines and pancreatic tumor specimens with 20q13 amplifications, the novel candidate gene NFAT C2, which plays a role in the activation of cytokines, was amplified. Other amplifications also affected genes for which a pathogenetic role in pancreatic carcinoma has not been described, such as BCL10 and BCL6, two members of the BCL family. A subset of amplified genes was checked for overexpression by means of real-time PCR, revealing the highest expression levels for BCL6 and BCL10. Thus, Matrix-CGH allows the detection of a high number of amplifications, resulting in the identification of novel candidate genes in pancreatic cancer. 相似文献
122.
Rath TJ Sundgren PC Brahma B Lieberman AP Chandler WF Gebarski SS 《Neuroradiology》2005,47(3):183-188
Subependymomas are benign intraventricular tumors with an indolent growth pattern, which are usually asymptomatic, and most commonly occur in the fourth and lateral ventricles. When symptomatic, subependymomas often obstruct critical portions of the cerebrospinal fluid (CSF) pathway, causing hydrocephalus, and range from 3 cm to 5 cm in size. We report a case of an unusually massive subependymoma of the lateral ventricles treated with subtotal resection, ventriculoperitoneal shunt, and post-surgical radiation. The clinical course, radiographic and pathologic characteristics of this massive intraventricular subependymoma are discussed, as well as the differential diagnosis of lateral ventricular masses and a review of the literature concerning subependymomas. 相似文献
123.
COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer 总被引:12,自引:6,他引:12
Buckman SY; Gresham A; Hale P; Hruza G; Anast J; Masferrer J; Pentland AP 《Carcinogenesis》1998,19(5):723-729
Extensive documentation has validated the role of UV irradiation as a tumor
initiator and promoter, inducing both squamous and basal cell carcinomas.
Human epidermis is a tissue which undergoes active metabolism of
arachidonic acid to prostaglandins which is regulated by the action of
prostaglandin H synthase (also known as cyclooxygenase). One mechanism for
the promotional activity of UV light may involve its ability to induce
prostaglandin formation. Work in our laboratory has demonstrated that acute
exposure of human keratinocytes to UVB irradiation results in increased
production of prostaglandin E2 (PGE2). When cultured human keratinocytes
were examined after irradiation with 30 mJ/cm2 UVB in vitro, Western blot
analysis showed a 6-fold increase in COX-2 protein which was evident at 6 h
and peaked 24 h after irradiation. Furthermore, when human subjects were
irradiated on sun- protected skin with up to four times their minimal
erythema dosage (MED) and biopsied 24 h later, upregulation of COX-2
protein expression was observed via immunofluorescence microscopy. RNAase
protection assays supported this observation, showing induction of COX-2
message which peaked at approximately 12 h following irradiation in vitro.
Furthermore, human squamous cell carcinoma biopsies exhibited strongly
enhanced staining for COX-2 protein via immunohistochemistry and Western
analysis when compared to normal non-sun-exposed control skin. Together,
these data demonstrate acute upregulation of COX-2 via UVB irradiation and
suggest the need for further studies of COX-2 expression as a potential
pharmacological target mediating human skin tumor development.
相似文献
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S Hopkins‐Donaldson R Cathomas AP Simes‐Wüst S Kurtz L Belyanskya RA Stahel U Zangemeister‐Wittke 《International journal of cancer. Journal international du cancer》2003,107(6):1058-1058
The original article to which this Erratum refers was published in International Journal of Cancer (2003) 106(2) 160–166 相似文献
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128.
Kargiotis O Rao JS Kyritsis AP 《中国神经肿瘤杂志》2006,4(1):51-51
Gliomas are the most frequent primary tumors of the central nervous system in adults. Glioblastoma muhiforme, the most aggressive form of astrocytic tumors, displays a rapid progression that is accompanied by particular poor prognosis of patients. Intense angiogenesis is a distinguishing pathologic characteristic of these tumors and in fact, glioblastomas are of the most highly vascularized malignant tumors. For this reason, research and therapy strategies have focused on derstanding the mechanisms leading to the origin of tumor angiogenic blood vessels in order to develop new approaches that effectively block angiogenesis and cause tumor regression. 相似文献
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