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41.
Schmitz C Welz A Dewald O Kozlik-Feldmann R Netz H Reichart B 《The Annals of thoracic surgery》2000,69(4):1270-1271
A 9-year-old boy with Kawasaki disease survived after two severe myocardial infarctions. Thereafter pharmacologically untreatable ventricular arrhythmia and rapidly deteriorating heart failure developed in the patient. After 19 days of biventricular and a further 27 days of left univentricular mechanical circulatory support with the Berlin Heart (Cardiotechnica, Berlin, Germany) assist device the boy successfully underwent heart transplantation. At a follow-up of 54 months, the boy is leading an active and unrestricted life. 相似文献
42.
Thorsten Zenz Markus Kreuz Maxi Fuge Wolfram Klapper Heike Horn Annette M. Staiger Doris Winter Hanne Helfrich Jennifer Huellein Martin‐Leo Hansmann Harald Stein Alfred Feller Peter M?ller Norbert Schmitz Lorenz Trümper Markus Loeffler Reiner Siebert Andreas Rosenwald German Ott Michael Pfreundschuh Stephan Stilgenbauer for the German High‐Grade Non‐Hodgkin Lymphoma Study Group 《International journal of cancer. Journal international du cancer》2017,141(7):1381-1388
TP53 is mutated in 20–25% of aggressive B‐cell lymphoma (B‐NHL). To date, no studies have addressed the impact of TP53 mutations in prospective clinical trial cohorts. To evaluate the impact of TP53 mutation to current risk models in aggressive B‐NHL, we investigated TP53 gene mutations within the RICOVER‐60 trial. Of 1,222 elderly patients (aged 61–80 years) enrolled in the study and randomized to six or eight cycles of CHOP‐14 with or without Rituximab (NCT00052936), 265 patients were analyzed for TP53 mutations. TP53 mutations were demonstrated in 63 of 265 patients (23.8%). TP53 mutation was associated with higher LDH (65% vs. 37%; p < 0.001), higher international prognostic index‐Scores (IPI 4/5 27% vs. 12%; p = 0.025) and B‐symptoms (41% vs. 24%; p = 0.011). Patients with TP53 mutation were less likely to obtain a complete remission CR/CRu (CR unconfirmed) 61.9% (mut) vs. 79.7% (wt) (p = 0.007). TP53 mutations were associated with decreased event‐free (EFS), progression‐free (PFS) and overall survival (OS) (median observation time of 40.2 months): the 3 year EFS, PFS and OS were 42% (vs. 60%; p = 0.012), 42% (vs. 67.5%; p < 0.001) and 50% (vs. 76%; p < 0.001) for the TP53 mutation group. In a Cox proportional hazard analysis adjusting for IPI‐factors and treatment arms, TP53 mutation was shown to be an independent predictor of EFS (HR 1.5), PFS (HR 2.0) and OS (HR 2.3; p < 0.001). TP53 mutations are independent predictors of survival in untreated patients with aggressive CD20+ lymphoma. TP53 mutations should be considered for risk models in DLBCL and strategies to improve outcome for patients with mutant TP53 must be developed. 相似文献
43.
Azria E Tsatsaris V Moriette G Hirsch E Schmitz T Cabrol D Goffinet F 《Journal de gynecologie, obstetrique et biologie de la reproduction》2007,36(3):245-252
Extreme premature child's long-term prognostic is getting better and better known, and if a resuscitation procedure is possible at birth, it won't guarantee survival or a survival free of disability. Incertitude toward individual prognosis and outcome for those children remains considerable. In this field, we are at the frontier of medical knowledge and the answer to the question, "how to decide the ante and postnatal care" is crucial. This work is focused on this problematic of decision-making in the context of extreme prematurity. It attempts to deconstruct this concept and to explicit its stakes. Thus, with the support of the medical sources and of philosophical debates, we tried to build a decision-making procedure that complies with the ethical requirements of medical care, accuracy, justice and equity. This decision-making procedure is primarily concerned with the singularity of each decision situation and it intends to link it closely to the notions of rationality and responsibility. 相似文献
44.
Azria E Tsatsaris V Moriette G Hirsch E Schmitz T Cabrol D Goffinet F 《Journal de gynecologie, obstetrique et biologie de la reproduction》2007,36(3):238-244
Extreme premature child's long-term prognostic is getting better and better known, and if a resuscitation procedure is possible at birth, it won't guarantee survival or a survival free of disability. Incertitude toward individual prognosis and outcome for those childs remains considerable. In this field, we are at the frontier of medical knowledge and the answer to the question, “how to decide the ante and postnatal care?” is crucial. This work is focused on this problematic of decision making in the context of extreme prematurity. It attempts to deconstruct this concept and to explicit its stakes. Thus, with the support of the medical sources and of philosophical debates, we tried to build a decision-making procedure that complies with the ethical requirements of medical care, accuracy, justice and equity. This decision-making procedure is primarily concerned with the singularity of each decision situation and it intends to link it closely to the notions of rationality and responsibility. 相似文献
45.
A. Schmitz Böhmig W. Dietrich H. Hruszek 《Journal of cancer research and clinical oncology》1939,49(4):145-146
Ohne Zusammenfassung 相似文献
46.
Haagen R. Dannee Isola Stahnke Krah A. Schmitz Hans W. Schmidt van der Plaats Merten O. Stahl Schlüter Bottler Büscher E. Gundersen Roedelius 《Journal of cancer research and clinical oncology》1943,53(6):327-332
Ohne Zusammenfassung 相似文献
47.
Küster Hans W. Schmidt E. Jacob W. Fischer Haagen A. Schmitz Merten Kloiber Annelise Schlüter Ostertag H. Nachtsheim Kürten Hans W. Schmidt Pohlandt Voss Breitländer Orzechowski Druckrey Krah Th. Naegeli Franz Sørensen Werthemann 《Journal of cancer research and clinical oncology》1942,53(3-4):188-199
Ohne Zusammenfassung 相似文献
48.
R. Curschmann A. Gottstein Seligmann Wohlwill Jacobsohn Manteufel Lewy Schmitz Koenigsfeld Taterka Jesionek Vaternahm Schall Sperling Freudenberg Eisner-Behrend O. Wiener B. Möllers Deusch Preuss Kraas Grassheim E. Grafe Osw Schwarz M. Rosenberg Pfaundler Jonas Simon Melchior Goldscheider Friedemann Mendel 《Journal of molecular medicine (Berlin, Germany)》1929,8(48):2250-2256
Ohne Zusammenfassung 相似文献
49.
Rona Gigon Grassheim Oberniedermayr Kraas C. Prausnitz Schmitz Weigert Oppenheimer Griesbach Friedemann Flury Goldstein Buschkejun Claus Schilling Buschke Jr Seligmann Lewy Weigert Edens Blumenfeldt Edens Vaternahm Oberniedermayr Hirsch Taterka Herzfeld SchÜbel H. Hirschfeld Rosenow Gottschalk Bernhardt Freudenberg Clara Bender Jonas Goldstein Dietrich Valentin Simon Oberniedermayr 《Journal of molecular medicine (Berlin, Germany)》1931,10(5):224-231
Ohne Zusammenfassung 相似文献
50.
Rona B. Flaschenträger Diepgen Peiper Grassheim Weil Schübel Bernhardt Grassheim Mündel Schmitz Lewy Forster Starkenstein Vaternahm Herzfeld Oppenheimer W. Fischer Christeller Deusch G. Katsch H. Hirschfeld Weigert Jonas Fressen Melchior Forster Meyer Valentin K. Hirschfeld O. Wiener Warsow Mendel Gruhle Goldstein Straus O. Wiener 《Journal of molecular medicine (Berlin, Germany)》1927,6(18):865-872
Ohne Zusammenfassung 相似文献