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41.
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Characterization of changes in total body composition for patients with head and neck cancer undergoing chemoradiotherapy using dual‐energy x‐ray absorptiometry
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Head and neck squamous cell carcinoma of unknown primary: Neck dissection and radiotherapy or definitive radiotherapy
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Myrna J. V. Brandt Cora H. Nijboer Isabell Nessel Tatenda R. Mutshiya Adina T. Michael-Titus Danielle S. Counotte Lidewij Schipper Niek E. van der Aa Manon J. N. L. Benders Caroline G. M. de Theije 《Nutrients》2022,14(1)
Perinatal hypoxia-ischemia (HI) is a major cause of neonatal brain injury, leading to long-term neurological impairments. Medical nutrition can be rapidly implemented in the clinic, making it a viable intervention to improve neurodevelopment after injury. The omega-3 (n-3) fatty acids docosahexaenoic acid (DHA, 22:6n-3) and eicosapentaenoic acid (EPA, 20:5n-3), uridine monophosphate (UMP) and choline have previously been shown in rodents to synergistically enhance brain phospholipids, synaptic components and cognitive performance. The objective of this study was to test the efficacy of an experimental diet containing DHA, EPA, UMP, choline, iodide, zinc, and vitamin B12 in a mouse model of perinatal HI. Male and female C57Bl/6 mice received the experimental diet or an isocaloric control diet from birth. Hypoxic ischemic encephalopathy was induced on postnatal day 9 by ligation of the right common carotid artery and systemic hypoxia. To assess the effects of the experimental diet on long-term motor and cognitive outcome, mice were subjected to a behavioral test battery. Lesion size, neuroinflammation, brain fatty acids and phospholipids were analyzed at 15 weeks after HI. The experimental diet reduced lesion size and neuroinflammation specifically in males. In both sexes, brain n-3 fatty acids were increased after receiving the experimental diet. The experimental diet also improved novel object recognition, but no significant effects on motor performance were observed. Current data indicates that early life nutritional supplementation with a combination of DHA, EPA, UMP, choline, iodide, zinc, and vitamin B12 may provide neuroprotection after perinatal HI. 相似文献
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Kristin Julia Glaas Marcel Fabian Schipper Jörg Klenzner Thomas Eysel-Gosepath Katrin Jansen Philipp Franz Matthias Schäfer Ralf 《European archives of oto-rhino-laryngology》2019,276(9):2441-2447
European Archives of Oto-Rhino-Laryngology - Since the 1980s, health-related quality of life (HRQOL) has been recognized in the assessment of medical treatment. To determine the health-related... 相似文献
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Derrien M van Passel MW van de Bovenkamp JH Schipper RG de Vos WM Dekker J 《Gut microbes》2010,1(4):254-268
Mucins are a family of heavily glycosylated proteins that are the major organic components of the mucus layer, the protective layer covering the epithelial cells in many human and animal organs, including the entire gastro-intestinal tract. Microbes that can associate with mucins benefit from this interaction since they can get available nutrients, experience physico-chemical protection and adhere, resulting in increased residence time. Mucin-degrading microorganisms, which often are found in consortia, have not been extensively characterized as mucins are high molecular weight glycoproteins that are hard to study because of their size, complexity and heterogeneity. The purpose of this review is to discuss how advances in mucus and mucin research, and insight in the microbial ecology promoted our understanding of mucin degradation. Recent insight is presented in mucin structure and organization, the microorganisms known to use mucin as growth substrate, with a specific attention on Akkermansia muciniphila, and the molecular basis of microbial mucin degradation owing to availability of genome sequences. 相似文献
50.
van Egmond PW Schipper IB van Luijt PA 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2012,22(3):201-207