全文获取类型
收费全文 | 752篇 |
免费 | 38篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 34篇 |
妇产科学 | 26篇 |
基础医学 | 59篇 |
口腔科学 | 35篇 |
临床医学 | 49篇 |
内科学 | 137篇 |
皮肤病学 | 23篇 |
神经病学 | 33篇 |
特种医学 | 147篇 |
外科学 | 123篇 |
综合类 | 25篇 |
预防医学 | 24篇 |
眼科学 | 13篇 |
药学 | 34篇 |
肿瘤学 | 31篇 |
出版年
2022年 | 3篇 |
2021年 | 8篇 |
2020年 | 3篇 |
2019年 | 5篇 |
2018年 | 12篇 |
2017年 | 7篇 |
2016年 | 9篇 |
2015年 | 22篇 |
2014年 | 16篇 |
2013年 | 29篇 |
2012年 | 23篇 |
2011年 | 29篇 |
2010年 | 35篇 |
2009年 | 35篇 |
2008年 | 26篇 |
2007年 | 53篇 |
2006年 | 49篇 |
2005年 | 46篇 |
2004年 | 36篇 |
2003年 | 23篇 |
2002年 | 18篇 |
2001年 | 34篇 |
2000年 | 11篇 |
1999年 | 3篇 |
1998年 | 23篇 |
1997年 | 37篇 |
1996年 | 21篇 |
1995年 | 23篇 |
1994年 | 16篇 |
1993年 | 6篇 |
1992年 | 6篇 |
1991年 | 3篇 |
1990年 | 8篇 |
1989年 | 14篇 |
1988年 | 9篇 |
1987年 | 15篇 |
1986年 | 9篇 |
1985年 | 10篇 |
1984年 | 5篇 |
1983年 | 9篇 |
1982年 | 7篇 |
1981年 | 10篇 |
1980年 | 12篇 |
1979年 | 1篇 |
1978年 | 4篇 |
1977年 | 7篇 |
1976年 | 8篇 |
1975年 | 5篇 |
1974年 | 1篇 |
排序方式: 共有804条查询结果,搜索用时 474 毫秒
71.
OBJECTIVES: The purpose of this study was to examine the underlying temperament and character properties of patients with bipolar disorder and explore the possible connections between these properties and clinical presentation of the illness. METHODS: The sociodemographic and clinical properties of 90 patients with bipolar disorder, who were euthymic according to Young Mania Rating Scale and Hamilton Depression Scale scores, were recorded. Their temperament and character features were evaluated by using Temperament and Character Inventory and results were compared with 90 age- and sex-matched healthy controls and between patients with different clinical properties. RESULTS: Patients' scores on subscales of self-directedness and cooperativeness were significantly lower compared with controls. Significant associations were found between Temperament and Character Inventory subtitles and comorbid personality disorder, number of episodes, subtype of the first episode, rapid cycling, and previous suicide attempt. CONCLUSIONS: Temperament and character features of patients with euthymic bipolar disorder show some significant differences compared to the healthy population and may vary according to different clinical presentations. 相似文献
72.
73.
Cardiac hydatid cyst disease is uncommon, representing approximately 0.2% to 2% of all cyst-related cases. Cardiac hydatid cysts are found mostly within the myocardium. Most cardiac hydatid cysts are located in the interventricular septum or in the left ventricular wall. Only few cases of pericardial location have been reported; isolated pericardial hydatid cysts are especially extremely rare. Patients with a cardiac hydatid cyst are usually asymptomatic. We present the case of an asymptomatic patient with isolated pericardial hydatid cyst disease and discuss the role of chest X-rays in the incidental diagnosis of this condition. 相似文献
74.
AG Stewart 《British journal of pharmacology》2009,158(4):933-935
The active resolution of inflammation is recognized as offering new opportunities to generate novel anti-inflammatory agents. The emerging appreciation of the importance of active resolution in regulation of inflammation also creates an imperative to examine developing and existing agents for their potential to influence these pathways. This themed issue of the British Journal of Pharmacology contains papers that discuss the roles of annexin-1, lipoxins and related lipid products of fish oils as well as other mechanisms involved in active resolution and their receptor targets.This article is part of a themed issue on Mediators and Receptors in the Resolution of Inflammation. To view this issue visit http://www3.interscience.wiley.com/journal/121548564/issueyear?year=2009 相似文献
75.
Background and purpose:
In the mammalian brain, histaminergic neurotransmission is mediated by the postsynaptic histamine H1 and H2 receptors and the presynaptic H3 autoreceptor, which also acts as a heteroreceptor. The H1 receptor has been implicated in spatial learning and memory formation. However, pharmacological and lesion studies have revealed conflicting results. To examine the involvement of histamine H1 receptor in spatial reference and working memory formation, H1 receptor knockout mice (KO) were tested in the eight-arm radial maze. Previously, we found that the H1 receptor-KO mice showed reduced emotionality when confronted with spatial novelty. As it is known that emotions can have an impact on spatial learning and memory performance, we also evaluated H1 receptor-KO mice in terms of emotional behaviour in the light–dark box.Experimental approach:
Mice lacking the H1 receptor and wild-type mice (WT) were tested for spatial reference and working memory in an eight-arm radial maze with three arms baited and one trial per day. Emotional behaviour was measured using the light–dark test.Key results:
The H1 receptor-KO mice showed impaired spatial reference and working memory in the radial maze task. No significant differences between H1 receptor-KO and WT mice were observed in the light–dark test.Conclusions and implications:
The spatial memory deficits of the H1 receptor-KO mice might be due to the reported changes in cholinergic neurochemical parameters in the frontal cortex and the CA1 subregion of the hippocampus, to impaired synaptic plasticity in the hippocampus, and/or to a dysfunctional brain reward/reinforcement system. 相似文献76.
Sayin MY Kaya B Bakkal BH Altundag K Altundag MB 《Medical oncology (Northwood, London, England)》2007,24(4):379-383
In this prospective study, we investigated the effects of hypofractionated radiotherapy for patients with high-grade gliomas.
About 31 patients with glioblastoma multiforme or anaplastic astrocytoma were studied between October 2003 and December 2004.
Hypofractionated radiotherapy (3 Gy/fraction/day) was delivered to a total dose of 45 Gy in 15 fractions in 10 patients (32%)
who had total excision before radiotherapy and to a total dose of 54 Gy in 18 fractions in 21 patients (68%) who had subtotal
excision or biopsy alone. Sex, age, type of surgery, tumor grade, Karnofsky performance status, time between surgery and initiation
of radiotherapy, and total radiotherapy dose were analyzed as potential prognostic factors for survival using the univariate
log-rank method. The median follow-up was 15 months (4–16 months). A total of 15 patients (48%) died of their illness; 16
patients (52%) were still alive at the last follow-up. The median survival time was 8 months. Actuarial 1–year overall survival
was 40%. Type of surgery, timing of radiotherapy after surgery, and initial Karnofsky performance status were significant
prognostic factors for survival. No grade 3–4 acute or late neurotoxicity was observed. The tolerance of patients to hypofractionated
RT was not different from that for conventional radiotherapy. This treatment schedule can be used for patients with high-grade
gliomas. Future investigations are needed to determine the optimal fractionation for high-grade gliomas. 相似文献
77.
Patty H Spruit Sabine Siesling Marloes AG Elferink Ernest JA Vonk Carel JM Hoekstra 《Radiation oncology (London, England)》2007,2(1):1-6
Background
To correlate the metabolic changes with size changes for tumor response by concomitant PET-CT evaluation of lung cancers after radiotherapy.Methods
36 patients were studied pre- and post-radiotherapy with18FDG PET-CT scans at a median interval of 71 days. All of the patients were followed clinically and radiographically after a mean period of 342 days for assessment of local control or failure rates. Change in size (sum of maximum orthogonal diameters) was correlated with that of maximum standard uptake value (SUV) of the primary lung cancer before and after conventional radiotherapy.Results
There was a significant reduction in both SUV and size of the primary cancer after radiotherapy (p < 0.00005). Among the 20 surviving patients, the sensitivity, specificity, and accuracy using PET (SUV) were 94%, 50%, 90% respectively and the corresponding values using and CT (size criteria) were 67%, 50%, and 65% respectively. The metabolic change (SUV) was highly correlated with the change in size by a quadratic function. In addition, the mean percentage metabolic change was significantly larger than that of size change (62.3 ± 32.7% vs 47.1 ± 26.1% respectively, p = 0.03)Conclusion
Correlating and incorporating metabolic change by PET into size change by concomitant CT is more sensitive in assessing therapeutic response than CT alone. 相似文献78.
Quality of life (QOL) has recently been explored as one of the main outcomes of renal replacement therapy. In this study, we sought to compare three groups of patients-hemodialysis, peritoneal dialysis, and transplantation-with regard to QOL. METHODS: Seventy-five hemodialysis, 41 peritoneal dialysis and 20 transplant patients were given Patient Information Form, Short Form Health Survey 36, Beck Depression Inventory, and State-Trait Anxiety Inventory. RESULTS: The QOL scores of the three groups were similar and lower than the normal Turkish population. Depression and anxiety levels had significant and negative effects on QOL of hemodialysis and peritoneal dialysis, but not transplant patients. In a multiple regression analysis, being male, being older than 46 years, living with family, having middle-higher income, having renal disease for a longer time, having a longer period of dialysis treatment, having comorbid illness, having not enough illness knowledge, and having higher levels of depression and of anxiety significantly correlated with a worse quality of life. CONCLUSIONS: The three forms of renal replacement therapy did not differ with regard to QOL. Among the factors that seem to affect QOL, psychological status and treatment/illness knowledge had the most significant correlation. The underlying mechanisms need to be clarified. 相似文献
79.
Ugurlucan M Sayin OA Surmen B Sungur Z Tireli E Dayioglu E 《The heart surgery forum》2007,10(1):E6-E8
Although truncus arteriosus is often treated with low mortality and morbidity rates, truncal valve patency and aortic arch and coronary artery anomalies are factors that can contribute to a worse outcome. In this report, we present our experience with the combination of Rastelli and Norwood procedures for the treatment of Type I truncus arteriosus that was complicated by a hypoplastic aortic arch. 相似文献
80.
Tension-free vaginal tape for surgical treatment of stress urinary incontinence: Two years follow-up
Hakki Perk Sedat Soyupek T Ahmet Serel Alim Koar Adnan Sayin M Burak Hocan 《International journal of urology》2003,10(3):132-135
BACKGROUND: The objective was to study prospectively the effectiveness of tension-free vaginal tape as an ambulatory and minimal invasive operation for the treatment of female stress incontinence. METHODS: The tension-free vaginal tape procedure was performed in 25 patients with genuine stress incontinence and they were followed for a 2-year period. All patients were diagnosed with urodynamics to have genuine stress incontinence. Pad tests, cough stress test and quality-of-life assessments were carried out in all patients, both preoperatively and postoperatively. The majority of the women were discharged the morning after the surgical procedure. RESULTS: Twenty of 25 (80%) patients were found to be cured 2 years after the operation. The vaginal tape was spontaneously dropped out from the vagina in one patient 2 weeks after the procedure. We did not see such a complication in previous studies. CONCLUSION: We conclude that the tension-free vaginal tape procedure is both a safe and effective method to cure genuine female stress incontinence. Furthermore, it can be performed as an ambulatory procedure under local anesthesia with a short operative time. 相似文献