The characteristics of the clinical course of lymphosarcomas when using combined therapy including splenectomy]

The authors relate the results of a clinico-morpho-instrumental analysis of the clinical course of lymphosarcomas in 38 patients with different morphological patterns of the disease with primary injury to the spleen. The patients received multimodality therapy including splenectomy. It has been established that later the short-term effect of splenectomy permits the implementation of different polychemotherapy programs, favouring a better lymphosarcoma prediction.     

Comparative analysis of the functional activity of neutrophil granulocytes from blood of patients with renal cell carcinoma before and after the surgical treatment

Patients with renal cell carcinoma (RCC) were examined by the chemiluminescent analysis before and after surgery. The cells of subjects with the discussed pathology were found to be in the state of functionally metabolic misbalance, i.e. an increased initial level of the synthesis of active oxygen with a relatively reduced cell reactivity when additionally stimulated. Such specificity of neutrophil granulocytes of peripheral blood is more pronounced in RCC patients after surgery. Supposedly, the above phenomenon is preconditioned by a lack of metabolic reserves that could provide an adequate functional response to extra stimulation and it develops due to a prolonged tumor progression and stress brought about by surgical intervention.