Low risk of viral infection after administration of vapor-heated factor VIII concentrate. International Investigator Group

A multicenter prospective study was carried out to evaluate whether a vapor-heated factor VIII concentrate transmitted blood-borne viral infections over a surveillance period of 15 months. Thirty-five patients with hemophilia and von Willebrand disease who had never received any blood components were treated. Twenty-eight were analyzed and found not to have non-A, non-B hepatitis. Sera from 20 of these 28 patients were also tested for the antibody to the hepatitis C virus. None had sero-converted during the follow-up period. None of the patients analyzed developed markers of the hepatitis B virus (n = 17) or the human immunodeficiency virus (n = 31). This vapor-heated factor VIII concentrate carries a low risk of transmitting hepatitis and human immunodeficiency virus infection.     

高效液相色谱法对四种双氯灭痛软膏剂透皮效果的研究

目的：本实验采用高效液相色谱法,以离体小白鼠腹部皮肤为透皮屏障,比较了四种双氯灭痛软膏剂的透皮效果,方法：实验用法国Gilson公司的HPLC仪,以C18为固定相,甲醇－水（含HAc 0.36%)=80:20为流动相,紫外检测波长280nm。平均回收率为99．59％,RSD＜3．28％,检测限为1．0ug/ml。结果：1号样品透皮率最高,3号与1号相比较透皮吸收无显著性差异（P＞0．05）,2号或4号分别与1号相比,其透皮吸收均有显著性差异（P＜0．05）,结论：1号品值得进一步开发。