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41.
Iain Livingstone Saraswathi Ramamurthi Suzannah Drummond Ewan Kemp Fiona Roberts 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2011,249(7):1091-1094
Background
The majority of lymphomas involving the eye and ocular adnexa are B-cell lymphomas. Ocular involvement by T-cell lymphoma is rare. We report a case of corneal perforation due to direct involvement of the corneal limbus by lymphoma in a patient with Sézary syndrome. 相似文献42.
43.
44.
William J. Huffman Saraswathi Subramaniyan Ramona M. Rodriguiz William C. Wetsel Warren M. Grill Niccolò Terrando 《Brain stimulation》2019,12(1):19-29
Background
The vagus nerve is involved in regulating immunity and resolving inflammation. Current strategies aimed at modulating neuroinflammation and cognitive decline, in many cases, are limited and ineffective.Objective
We sought to develop a minimally invasive, targeted, vagus nerve stimulation approach (pVNS), and we tested its efficacy with respect to microglial activation and amelioration of cognitive dysfunction following lipopolysaccharide (LPS) endotoxemia in mice.Methods
We stimulated the cervical vagus nerve in mice using an ultrasound-guided needle electrode under sevoflurane anesthesia. The concentric bipolar needle electrode was percutaneously placed adjacent to the carotid sheath and stimulation was verified in real-time using bradycardia as a biomarker. Activation of vagal fibers was confirmed with immunostaining in relevant brainstem structures, including the dorsal motor nucleus and nucleus tractus solitarius. Efficacy of pVNS was evaluated following administration of LPS and analyses of changes in inflammation and behavior.Results
pVNS enabled stimulation of the vagus nerve as demonstrated by changes in bradycardia and histological evaluation of c-Fos and choline acetyltransferase expression in brainstem nuclei. Following LPS administration, pVNS significantly reduced plasma levels of tumor necrosis factor-α at 3?h post-injection. pVNS prevented LPS-induced hippocampal microglial activation as analyzed by changes in Iba-1 immunoreactivity, including cell body enlargement and shortened ramifications. Cognitive dysfunction following endotoxemia was also restored by pVNS.Conclusion
Targeted cervical VNS using this novel percutaneous approach reduced LPS-induced systemic and brain inflammation and significantly improved cognitive responses. These results provide a novel therapeutic approach using bioelectronic medicine to modulate neuro-immune interactions that affect cognition. 相似文献45.
46.
Vedam Saraswathi Zephyrin Laurie Hardtman Pandora Lusero Indra Olson Rachel Hassan Sonia S. van den Broek Nynke Stoll Kathrin Niles Paulomi Goode Keisha Nunally Lauren Kandal Remi Bair James W. 《Maternal and child health journal》2022,26(4):674-681
Maternal and Child Health Journal - Inequities in birth outcomes are linked to experiential and environmental exposures. There have been expanding and intersecting wicked problems of inequity,... 相似文献
47.
Saraswathi Vedam Kathrin Stoll Daphne N. McRae Mo Korchinski Raquel Velasquez Jessie Wang Sarah Partridge Lorna McRae Ruth Elwood Martin Ganga Jolicoeur 《Patient education and counseling》2019,102(3):586-594
Objective
The Changing Childbirth in British Columbia study explored women’s preferences and experiences of maternity care, including women’s role in decision-making.Methods
Following content validation by community members, we administered a cross-sectional online survey exploring novel topics, including drivers for interventions, and experiences of autonomy, respect, or mistreatment during maternity care. Using the Mothers Autonomy in Decision-Making (MADM) scale as an outcome measure in a mixed-effects analysis, we examined differential experiences by socio-demographic and prenatal risk profile, type of care provider, interventions received, and nature of communication with care providers.Results
A geographically representative sample of Canadian women (n?=?2051) reported on 3400 pregnancies. Most women (95.2%) preferred to be the lead decision-maker during care. Patients of physicians had significantly lower autonomy (MADM) scores than midwifery clients as did women who felt pressured to accept interventions. Women who had a difference in opinion with their provider, and those who felt their provider seemed rushed reported the lowest MADM scores.Conclusion
Women’s autonomy is significantly altered by model of maternity care, the nature of interactions with care providers, and women’s ability for self-determination.Practice Implications
If health professionals acquire skills in person-centred decision-making experience of autonomy among pregnant women may improve. 相似文献48.
Jasin Arachchige Saman Bingumal Jayasundara Waradana Mohan Malith de Silva Ajith Aloka Pathirana 《Hepatobiliary & Pancreatic Diseases International》2011,(5)
BACKGROUND: Biliary tract injuries are mostly iatrogenic Related data are limited in developing countries. There are lessons to be learned by revisiting the clinical profiles management issues and outcome of patients referred to a tertiary care center in Sri Lanka, compared with the previous data from the same center published in 2006. Such a review is particularly relevant at a time of changing global perceptions of iatrogenic biliary injuries. This study aimed to analyze and compare the changes in the inj... 相似文献
49.
Perle Feldman MDCM CCFP FCFP Rivka Cymbalist CD Saraswathi Vedam RM MSN FACNM SciD Andrew Kotaska MD FRCSC 《分娩》2010,37(3):245-251
Abstract: The stories in this Roundtable Discussion are related by two women whose babies were born recently in Canadian hospitals. Each woman had undergone a cesarean delivery for her first child, and whereas Sophia delivered her second baby by vaginal birth after a cesarean (VBAC), Marie was unable to find a practitioner or hospital that would allow her to have a VBAC for her second birth. The women describe how they feel about their choices and experiences. Their two accounts and the issues that they raise are discussed in commentaries by a family physician, midwife, doula, and obstetrician. (BIRTH 37:3 September 2010) 相似文献
50.
Saraswathi Simansalam Joan M. Brewster Mohamad Haniki Nik Mohamed 《American journal of pharmaceutical education》2015,79(5)
Objective. To evaluate the feasibility of an online training module, Certified Smoking Cessation Service Provider (CSCSP), developed for practicing pharmacists to equip pharmacy students with knowledge necessary for smoking cessation counseling and to assess the changes in student knowledge and skills regarding smoking cessation following training.Design. Sixty third-year and 80 fourth-year pharmacy undergraduates (N=140) were given access to an online module, the main intervention in the study. Two linkable questionnaires were administered to assess students’ preintervention and postintervention knowledge. For the third-year students, an additional role-play training component was incorporated, and student skills were assessed during week 14 with an Objective Structured Clinical Examination (OSCE).Assessment. Preintervention and postintervention knowledge assessments were completed by 130 (92.8%) students. Sixty-six students scored above 50% for the knowledge component postintervention, compared to 13 at preintervention, demonstrating significant improvement (x2(1, N=130)=32, p=0.003). All third-year students completed the intervention, and 66.7% were able to counsel excellently for smoking cessation, scoring more than 80%.Conclusion. The CSCSP online module developed for practicing professionals was found suitable for equipping pharmacy undergraduates with knowledge on smoking cessation topics. The module, along with role-play training, also equipped students with knowledge and skills to provide smoking cessation counseling. 相似文献