Effect of Hearing Rehabilitation Therapy Program in Hearing Aid Users: A Prospective Randomized Controlled Study

ObjectivesDespite sufficient hearing gains, many patients with hearing loss have difficulty using hearing aids due to poor word recognition ability. This study was performed to introduce our hearing rehabilitation therapy (HRT) program for hearing aid users and to evaluate its effect on hearing improvement.MethodsIn this prospective randomized case-control study, 37 participants with moderate or moderate-severe sensorineural hearing loss who had used bilateral hearing aids for more than 3 months with sufficient functional hearing gain were enrolled in this study. Nineteen participants were randomly assigned to the control group (CG) and 18 patients were assigned to participate in our HRT program once a week for 8 consecutive weeks (hearing rehabilitation therapy group [HRTG]). Their hearing results and questionnaire scores for hearing handicap and hearing aid outcomes were prospectively collected and compared between the two groups.ResultsAfter completing 8 weeks of the HRT program, the HRTG showed a significantly greater improvement in scores for consonant-only and consonant-vowel sound perception than the CG (P<0.05). In addition, the HRTG showed a significant improvement in hearing ability as measured by two questionnaires (P<0.05), while no differences were observed in the CG. However, word and sentence recognition test results did not show significant differences between the two groups.ConclusionEven after short-term HRT, patients had subjectively better hearing outcomes and improved phoneme perception ability; this provides scientific evidence regarding a possible positive role for HRT programs in hearing aid users. Further validation in a larger population through a long-term follow-up study is needed.     

当归、枳壳挥发油HPLC指纹图谱的研究

目的:研究不同批次当归、枳壳药材经CO2超临界混合萃取的挥发油的指纹图谱,为科学评价和有效控制其质量提供实验依据.方法:采用高效液相色谱,条件为伊利特ODS 2 C18(4.6 mm ×250 mm,5μm)色谱柱,乙腈-水为流动相,梯度洗脱,柱温30℃,流速1.0 mL·min-1,检测波长325 nm.结果:建立了11个不同批次的当归、枳壳混合提取挥发油的指纹图谱,以蒿本内酯峰为参照峰,共标定了13个共有峰,利用化学对照品指认了其中2个色谱峰;该指纹图谱可鉴别当归、枳壳经水蒸汽蒸馏法得的挥发油.结论:方法准确可靠,可用于控制淫藤骨痹康方中的挥发油的质量.     

资源需求型智慧教育模式在康复评定学教学中的应用

在信息技术不断变革创新的时代,智慧教育模式在逐渐取代传统的教学模式,学习者"学习方式"正在发生深刻的变革,对学习资源的需求也在改变,人们需要学习资源多样化、微型化、切需化,以适应新的学习文化和学习方式.在我校康复评定学课程教学中,我们引入智慧教育模式,开展康复评定学课程"资源需求型"研究,以期探索符合当前信息时代的高等...     

孕激素对卵巢癌细胞体外生长的影响

目的　探讨孕激素对人卵巢癌细胞体外生长的影响。方法　采用四甲基偶氮唑蓝MTT比色法观察孕酮对卵巢癌细胞株HO - 891 0体外生长的影响 ;免疫组化法观察孕酮作用后HO - 891 0雌激素受体、孕激素受体及雄激素受体的变化。结果　 1× 1 0 -6～ 1× 1 0 -5mol/L的孕酮作用 4 8h和 72h对HO - 891 0细胞生长有抑制 ;作用 2 1d后 1× 1 0 -5mol/L时出现明显的抑制作用 ;但是孕激素未影响HO - 891 0雌激素受体、孕激素受体及雄激素受体蛋白的表达 ,为孕激素临床应用提供间接依据。结论　孕激素可抑制卵巢癌细胞株的体外生长但未改变细胞的激素受体表达     

Expression of cyclooxygenase-2 in association with clinicopathological prognostic factors and molecular markers in epithelial ovarian cancer

OBJECTIVES: This study examines whether expression of COX-2 is associated with clinicopathological features and other molecular markers of ovarian cancer. METHODS: Sixty-four paraffin-embedded tissue specimens were obtained from patients with ovarian cancer who received cytoreductive surgery and combination chemotherapy. Tissue specimens were subjected to immunohistochemical analysis using antibodies to COX-2, p53, and VEGF. RESULTS: Increased COX-2 expression significantly correlated with histologic type (mucinous 5.6% vs. non-mucinous 65.2%, P<0.001). COX-2 expression was also significantly associated with stage, tumor grade, residual disease status, and presence of ascites. COX-2 expression correlated positively with expression of p53 (P=0.006) and VEGF (P=0.025). Although survival was lower in patients with high COX-2 expression than in those without high COX-2 expression (P<0.001), only tumor grade and stage were independent prognostic indicators. In patients with non-mucinous cancer, COX-2 expression correlated with stage (P<0.001) and presence of ascites (P=0.033). CONCLUSIONS: Our results suggest that expression of COX-2 in ovarian cancers is specific to histologic type of tumor and is associated with poor clinicopathologic prognostic factors. Expression of COX-2 also correlates well with expression of p53 and VEGF.     

痛风丸联合非布司他治疗高尿酸血症

目的 通过比较痛风丸、非布司他联合用药与单独使用非布司他、痛风丸治疗痛风的疗效,评价联合用药治疗痛风的有效性.方法 选择痛风患者130例,随机分为对照组、研究1组和研究2组,对照组只给予非布司他治疗,研究1组只给予痛风丸治疗,研究2组给予非布司他联合痛风丸治疗,治疗周期2个月.结果 3组治疗前后肿胀疼痛积分、证候积分、...     

Development of cyclosporin A-loaded hyaluronic microsphere with enhanced oral bioavailability

To develop a hyaluronic microsphere with the improved oral bioavailability of poorly water-soluble cyclosporin A (CsA), the microspheres were prepared with varying ratios of sodium hyaluronate (HA)/sodium lauryl sulfate (SLS)/CsA using a spray-drying technique. The effects of HA and SLS on the dissolution and solubility of CsA in microspheres were investigated. The CsA-microsphere prepared with HA/SLS/CsA at the ratio of 4/2/1 gave the highest solubility and dissolution rate of CsA among those formulae tested. As solubility and dissolution rate of CsA were increased about 17- and 2-fold compared to CsA powder, respectively, this CsA-microsphere was selected as an optimal formula for oral delivery in rats. The CsA-microsphere and Sandimmun neoral sol gave significantly higher blood levels compared with CsA powder alone. Moreover, the AUC, T(max) and C(max) values of CsA in CsA-microsphere were not significantly different from those in Sandimmun neoral sol in rats, indicating that CsA-microsphere was bioequivalent to the commercial product in rats. Our results demonstrated that the CsA-microsphere prepared with HA and SLS, with improved bioavailability of CsA, might have been useful to deliver a poorly water-soluble CsA.     

云南漾濞不同地区核桃林下种植重楼的重楼皂苷含量比较

摘 要 目的：对云南漾濞不同地区核桃林下栽种重楼中的4种重楼皂苷含量进行比较。方法: 采集云南漾濞不同地区核桃林下栽种的重楼样品,按中国药典2015年版收载的方法进行含量测定。结果: 云南漾濞不同地区栽种重楼中4种重楼皂苷含量各样品间存在显著差异。样品均为仿野生林下载培,但载培时间长短不一,其中生长年限4~5年的重楼药材中4种重楼皂苷含量明显高于3年生重楼。结论:4种重楼皂苷含量各样品间存在显著差异与重楼生长的生态环境、生长年限和同一物种不同居群间遗传背景等不同有关。     

平调饮对原发性肝癌AFP mRNA、GPC-3 mRNA影响的研究

目的探讨平调饮对原发性肝癌患者AFP mRNA、GPC-3 mRNA表达的影响。方法抽取60例肝癌患者的抗凝血液,配对法随机分为试验组和对照组各30例。采用Tr-Izol一步法提取总RNA,用逆转录巢式聚合酶链反应(RT-nested PCR)技术检测治疗前后试验组及对照组患者AFP mRNA、GPC-3 mRNA的表达情况。结果治疗后试验组及对照组AFP mRNA、GPC-3 mRNA表达均显著下降,在降低AFP mRNA表达方面试验组与对照组无显著性差异,降低GPC-3 mRNA表达方面试验组明显优于对照组(P0.05)。结论平调饮能有效抑制人血液中AFP mRNA、GPC-3 mRNA的高表达,在降低GPC-3 mRNA表达方面效果优于华蟾素。其治疗原发性肝癌机制与临床应用价值值得进一步研究。     

Triple Therapy-Based on Tegoprazan,a New Potassium-Competitive Acid Blocker,for First-Line Treatment of Helicobacter pylori Infection: A Randomized,Double-Blind,Phase III,Clinical Trial

Background/AimsWe examined the efficacy and safety of tegoprazan as a part of first-line triple therapy for Helicobacter pylori eradication.MethodsA randomized, double-blind, controlled, multicenter study was performed to evaluate whether tegoprazan (50 mg)-based triple therapy (TPZ) was noninferior to lansoprazole (30 mg)-based triple therapy (LPZ) (with amoxicillin 1 g and clarithromycin 500 mg; all administered twice daily for 7 days) for treating H. pylori. The primary endpoint was the H. pylori eradication rate. Subgroup analyses were performed according to the cytochrome P450 (CYP) 2C19 genotype, the minimum inhibitory concentration (MIC) of amoxicillin and clarithromycin, and underlying gastric diseases.ResultsIn total, 350 H. pylori-positive patients were randomly allocated to the TPZ or LPZ group. The H. pylori eradication rates in the TPZ and LPZ groups were 62.86% (110/175) and 60.57% (106/175) in an intention-to-treat analysis and 69.33% (104/150) and 67.33% (101/150) in a per-protocol analysis (non-inferiority test, p=0.009 and p=0.013), respectively. Subgroup analyses according to MICs or CYP2C19 did not show remarkable differences in eradication rate. Both first-line triple therapies were well-tolerated with no notable differences.ConclusionsTPZ is as effective as proton pump inhibitor-based triple therapy and is as safe as first-line H. pylori eradication therapy but does not overcome the clarithromycin resistance of H. pylori in Korea (ClinicalTrials.gov identifier {"type":"clinical-trial","attrs":{"text":"NCT03317223","term_id":"NCT03317223"}}NCT03317223).