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991.
Sandra M. Vioque Patrick K. Kim Janet McMaster John Gallagher Steven R. Allen Daniel N. Holena Patrick M. Reilly Jose L. Pascual 《American journal of surgery》2014
Background
Benchmarking and classification of avoidable errors in trauma care are difficult as most reports classify errors using variable locally derived schemes. We sought to classify errors in a large trauma population using standardized Joint Commission taxonomy.Methods
All preventable/potentially preventable deaths identified at an urban, level-1 trauma center (January 2002 to December 2010) were abstracted from the trauma registry. Errors deemed avoidable were classified within the 5-node (impact, type, domain, cause, and prevention) Joint Commission taxonomy.Results
Of the 377 deaths in 11,100 trauma contacts, 106 (7.7%) were preventable/potentially preventable deaths related to 142 avoidable errors. Most common error types were in clinical performance (inaccurate diagnosis). Error domain involved primarily the emergency department (therapeutic interventions), caused mostly by knowledge deficits. Communication improvement was the most common mitigation strategy.Conclusion
Standardized classification of errors in preventable trauma deaths most often involve clinical performance in the early phases of care and can be mitigated with universal strategies. 相似文献992.
Alexander Iribarne Helena Chang John H. Alexander A. Marc Gillinov Ellen Moquete John D. Puskas Emilia Bagiella Michael A. Acker Mary Lou Mayer T. Bruce Ferguson Sandra Burks Louis P. Perrault Stacey Welsh Karen C. Johnston Mandy Murphy Joseph J. DeRose Alexis Neill Edlira Dobrev Kim T. Baio Wendy Taddei-Peters Alan J. Moskowitz Patrick T. O’Gara 《The Annals of thoracic surgery》2014
993.
Electroencephalography (EEG) has, historically, played a focal role in the assessment of neural function in children with attention deficit hyperactivity disorder (ADHD). We review here the most recent developments in the utility of EEG in the diagnosis of ADHD, with emphasis on the most commonly used and emerging EEG metrics and their reliability in diagnostic classification. Considering the clinical heterogeneity of ADHD and the complexity of information available from the EEG signals, we suggest that considerable benefits are to be gained from multivariate analyses and a focus towards understanding of the neural generators of EEG. We conclude that while EEG cannot currently be used as a diagnostic tool, vast developments in analytical and technological tools in its domain anticipate future progress in its utility in the clinical setting. 相似文献
994.
Amy A. Herrold ;Sandra L. Kletzel ;Brett C. Harton ;R. Andrew Chambers ;Neil Jordan ;Theresa Louise-Bender Pape 《中国神经再生研究》2014,9(19):1712-1730
Alcohol use disorder (AUD), mild traumatic brain injury (mTBI), and posttraumatic stress disorder (PTSD) commonly co-occur (AUD + mTBI + PTSD). These conditions have overlapping symptoms which are, in part, reflective of overlapping neuropathology. These conditions become problematic because their co-occurrence can exacerbate symptoms. Therefore, treatments must be developed that are inclusive to all three conditions. Repetitive transcranial magnetic stimulation (rTMS) is non-invasive and may be an ideal treatment for co-occurring AUD + mTBI + PTSD. There is accumulating evidence on rTMS as a treatment for people with AUD, mTBI, and PTSD each alone. However, there are no published studies to date on rTMS as a treatment for co-occurring AUD + mTBI + PTSD. This review article advances the knowledge base for rTMS as a treatment for AUD + mTBI + PTSD. This review provides background information about these co-occurring conditions as well as rTMS. The existing literature on rTMS as a treatment for people with AUD, TBI, and PTSD each alone is reviewed. Finally, neurobiological findings in support of a theoretical model are discussed to inform TMS as a treatment for co-occurring AUD + mTBI + PTSD. The peer-reviewed literature was identified by targeted literature searches using PubMed and supplemented by cross-referencing the bibliographies of relevant review articles. The existing evidence on rTMS as a treatment for these conditions in isolation, coupled with the overlapping neuropathology and symptomology of these conditions, suggests that rTMS may be well suited for the treatment of these conditions together. 相似文献
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996.
997.
Michael A. Jhung Tiffany D'Mello Alejandro Pérez Deborah Aragon Nancy M. Bennett Tara Cooper Monica M. Farley Brian Fowler Stephen M. Grube Emily B. Hancock Ruth Lynfield Craig Morin Arthur Reingold Patricia Ryan William Schaffner Ruta Sharangpani Leslie Tengelsen Ann Thomas Diana Thurston Kimberly Yousey-Hindes Shelley Zansky Lyn Finelli Sandra S. Chaves 《American journal of infection control》2014
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Agnes Mattsson Sandra E. Sylvan Anna Asklid Joel Wiggh Maria Winqvist Jeanette Lundin Larry Mansouri Richard Rosenquist Hemming Johansson Anders Österborg Lotta Hansson 《British journal of haematology》2020,191(3):426-432
Bendamustine + rituximab (BR) is the current first-line standard-of-care for chronic lymphocytic leukaemia (CLL) in fit patients aged 66–70 years, whereas chlorambucil + CD20 antibody is recommended in older patients with co-morbidities. This retrospective real-world study investigated whether risk-adapted BR was safe and effective in elderly patients. All 141 CLL patients in the Stockholm region (diagnosed from 2007 to 2016, identified from regional registries) who had received BR as first (n = 84) or later line (n = 57) were analysed. Median age was 72 years, 49% had Binet stage C, 40% had Cumulative Illness Rating Scale (CIRS) score ≥ 6, 20% Eastern Cooperative Oncology Group (ECOG) score 2. None had del(17p). Only 15% of patients aged ≥80 years received full-dose bendamustine and 65% of them postponed rituximab until cycle 2. Corresponding numbers in patients 73–79 years were 21% and 36% and in <73 years, 63% and 33%. Overall response rate was 83% (first line) and 67% (later line) (P < 0·022) equally distributed between age subsets. ECOG, immunoglobulin heavy chain variable region (IGHV) mutational status and cytogenetics, but not treatment line and age, were significant factors on progression-free survival (PFS) in multivariate analysis. Infections and neutropenia/thrombocytopenia (≥grade 3) were similar across age subgroups. In summary, BR was well tolerated even in patients ≥80 years, with similar efficacy and safety as in less old patients, provided that carefully adapted dosing was applied. 相似文献