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Maxence Meyer MD Lidia Calabrese MD Anita Meyer MD Florentin Constancias PhD Louise F. Porter MD PhD Marion Muller Manon Leitner Amandine Leitner Antonin Michaud Georges Kaltenbach MD PhD Elise Schmitt MD PhD Patrick Karcher MD Erik Sauleau MD PhD Saïd Chayer PhD HDR Floriane Zeyons MD Marianne Riou MD Soraya El Ghannudi Abdo MD Frédéric Blanc MD PhD Samira Fafi-Kremer PharmD PhD Aurélie Velay PharmD PhD Thomas Vogel MD PhD 《Journal of the American Geriatrics Society》2021,69(5):1167-1170
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Jadidi Nilofar Alesaeidi Samira Arab Fatemeh Pakzad Bahram Siasi Elham Esmaeilzadeh Emran 《Clinical rheumatology》2022,41(11):3487-3494
Clinical Rheumatology - MiRSNPs may interfere with mRNA stability through effects on microRNAs (miRNAs)-mRNA interactions via direct changes in miRNA binding site or effect on the secondary... 相似文献
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Tumor-resident adenosine-producing mesenchymal stem cells as a potential target for cancer treatment
Arab Samaneh Alizadeh Akram Asgharzade Samira 《Clinical and experimental medicine》2021,21(2):205-213
Clinical and Experimental Medicine - The development of new therapies based on tumor biology is one of the main topics in cancer treatment. In this regard, investigating the... 相似文献
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Maria Lúcia R de Rezende Pedro T.G. Coesta Rodrigo C. de Oliveira Samira Salmeron Adriana C.P. Sant'Ana Carla A. Damante Sebastião L.A. Greghi Alberto Consolaro 《Journal of periodontology》2015,86(1):146-154
Background: Previous studies have demonstrated that bone demineralization can improve consolidation in bone grafts. The biologic mechanisms underlying this phenomenon remain unclear. Methods: Twelve adult male guinea pigs were used in this experiment. Forty‐five bone samples removed from the calvaria of nine animals were divided in groups (n = 9) according to the time of demineralization with citric acid (50%, pH 1): 15, 30, 90, and 180 seconds and non‐demineralized samples (control). Preosteoblasts (MC3T3‐E1) were cultured on the bone samples for 24, 48, and 72 hours (n = 3). Fifteen samples removed from the remaining three animals were analyzed by scanning electron microcopy/energy dispersive spectrometry (SEM/EDS) after demineralization (n = 3). Results: The number of preosteoblasts increased significantly with time in all groups. The bone surface area covered by these cells increased with time, except in the control group. Intragroup differences occurred between 24 and 72 hours (P <0.05). Samples demineralized for 30 seconds showed greater area covered by preosteoblast cells than for the other times of demineralization in all periods of cell culture (P <0.05) without a statistically significant difference compared with 15 seconds. SEM/EDS showed diminished content of calcium (Ca) after 15 seconds of demineralization, but the Ca content increased after 180 seconds of demineralization (P <0.05). The phosphorus (P) amount increased significantly only after 30 seconds of demineralization (P <0.5). The sulfur (S) content was increased in demineralized samples in relation to non‐demineralized ones, reaching the highest level after 90 seconds, when the difference became significant in relation to all the other times of demineralization (P <0.05). Magnesium (Mg) content did not differ significantly between demineralized and non‐demineralized samples. Conclusions: Bone surfaces demineralized for 30 seconds increased the spreading of preosteoblasts as well as the surface area covered by these cells. Bone demineralization deserves to be studied in periodontal and maxillofacial regenerative procedures. 相似文献
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[Purpose] Obesity is a global health problem and is associated with a multitude of
complications. This study was designed to determine changes in cardiopulmonary functions
after aerobic and anaerobic exercise training in obese subjects. [Subjects and Methods]
Forty obese subjects, whose ages ranged between 18 and 25 years, were divided into 2 equal
groups: group A received aerobic exercise training in addition to dietary measures, and
group B received anaerobic exercise training for 3 months in addition to dietary measures.
Measurements of systolic blood pressure, diastolic blood pressure, heart rate, maximum
voluntary ventilation, maximal oxygen consumption, and body mass index were obtained for
both groups before and after the exercise program. [Results] The mean body mass index,
systolic blood pressure, diastolic blood pressure, heart rate, and maximal oxygen
consumption decreased significantly, whereas the mean maximum voluntary ventilation
increased significantly after treatment in group A. The mean maximum voluntary ventilation
also increased significantly after treatment in group B. There were significant
differences between the mean levels of the investigated parameters in groups A and B after
treatment. [Conclusion] Aerobic exercise reduces weight and improves cardiopulmonary
fitness in obese subjects better than anaerobic exercise.Key words: Obesity, Aerobic, Anaerobic 相似文献
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Costa JM Tsutsui JM Nozawa E Morhy SS Andrade JL Ramires JF Mathias W 《Echocardiography (Mount Kisco, N.Y.)》2005,22(5):389-394
Patients in an intensive care unit (ICU) under mechanical ventilation (MV) are very difficult to image by transthoracic echocardiography, diminishing the beneficial information that could be obtained by this noninvasive approach. The objective of this study is to assess whether the addition of a contrast agent to fundamental imaging (FI) can improve or change the initial diagnosis in cardiac postoperative patients under mechanical ventilation by enhancing endocardial border delineation and Doppler flow signal. Thirty mechanically ventilated post-cardiac surgery patients (20 men, mean age 61 +/- 13 years) were evaluated with FI before and after intravenous injection of contrast. Left ventricular endocardial border delineation score index (EBDSI), estimated left ventricular ejection fraction (LVEF), and color and spectral Doppler were analyzed. The use of contrast resulted in a significant increase in the number of well-delineated segments, with a salvage rate of 77% of nondiagnostic studies. EBDSI was 1.62 +/- 0.61, before contrast, increasing to 2.05 +/- 0.53 after it (P < 0.001). There was a change in the LVEF estimation in 5 exams, and a new wall motion abnormality was detected in other 4 exams, after the use of contrast. Moreover, a significant change was observed in the quantification of mitral regurgitation in 5 patients, in the aortic transvalvular peak gradient in 1 patient, and measurement of tricuspid regurgitation peak flow velocity in 8 patients. It is concluded that in cardiac postoperative patients under mechanical ventilation, intravenous injection of a contrast agent using FI resulted in a high salvage rate of studies and changed the initial diagnosis in a significant number of patients. 相似文献