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排序方式: 共有284条查询结果,搜索用时 15 毫秒
281.
Takehiko Tanaka Shigeki Umemura Tomohiro Miyoshi Tokiko Nakai Osamu Noritake Jun Suzuki Kenta Tane Joji Samejima Keiju Aokage Sachiyo Mimaki Katsuya Tsuchihara Tetsuro Taki Saori Miyazaki Reiko Watanabe Shingo Sakashita Naoya Sakamoto Motohiro Kojima Koichi Goto Norihiko Ikeda Masahiro Tsuboi Genichiro Ishii 《Pathology international》2023,73(10):497-508
Alveolar macrophages (AMs) are resident macrophages in the lungs; however, whether the number of AMs plays a role in the lung neuroendocrine tumor (NET) prognosis remains unclear. We counted the number of AMs located around the tumor (peritumoral alveolar macrophages [pAMs]) and the number of AMs located apart from the tumor (distant macrophages; dAMs). In 73 cases of neuroendocrine carcinoma (NEC: small cell lung carcinoma and large cell neuroendocrine carcinoma), the group that contained higher pAMs (≥86/μm2) revealed shorter recurrent-free survival (RFS) than those with lower pAMs (<86/μm2) (p = 0.005). Bivariate analysis showed that the number of pAMs was an independent predictor of a poor RFS. In contrast, in the carcinoid tumor cohort (n = 29), there was no statistically significant correlation between the two groups with high and low numbers of pAMs in RFS (p = 0.113). Furthermore, we examined the correlation between genomic alterations and the number of pAMs in NEC, but no significant correlation was observed. In conclusion, the number of pAMs is a prognostic factor for NEC in the lung and pAMs may contribute to tumor progression within the peritumoral microenvironment. 相似文献
282.
Yasuhito Konishi Tetsuro Taki Tokiko Nakai Takashi Kuroe Ryo Morisue Tomohiro Miyoshi Kenta Tane Joji Samejima Keiju Aokage Saori Miyazaki Naoya Sakamoto Shingo Sakashita Reiko Watanabe Motohiro Kojima Kenji Suzuki Masahiro Tsuboi Genichiro Ishii 《Cancer science》2023,114(5):2169-2177
Dirty necrosis (DN) is a form of tumor necrosis (TN) with prominent neutrophil infiltration and cell detritus in the necrotic foci. This study aimed to characterize the clinicopathological features of DN in metastatic lung cancers of the colon and rectum (MLCRs). A total of 227 patients who underwent pulmonary metastasectomy and complete resection for MLCR were included in this study. TN was evaluated using digitally scanned resection specimens. These slides were immunostained for biomarkers of NETosis (citrullinated histone H3 [citH3] and myeloperoxidase [MPO]), and the area positive for citH3 and MPO was further quantified. TN was observed in 216 cases (95.2%), and 54 (25.0%) of these cases had DN. The presence of TN was not associated with a worse prognosis; however, patients with DN had a significantly shorter overall survival than those without DN (p < 0.01). Furthermore, the presence of DN was a poor prognostic factor in both the univariate and multivariate analyses. Immunohistochemical analysis revealed that the percentage of citH3-positive and MPO-positive areas in the DN-positive cases was significantly higher than that in the DN-negative cases (p < 0.01 and p < 0.01, respectively). In surgically resected MLCR, DN is the characteristic TN subtype associated with poor prognosis and neutrophil extracellular traps (NETs). 相似文献
283.
Takaaki Kosugi Masahiro Eriguchi Hisako Yoshida Takayuki Uemura Hikari Tasaki Fumihiro Fukata Masatoshi Nishimoto Masaru Matsui Ken-ichi Samejima Kunitoshi Iseki Shouichi Fujimoto Tsuneo Konta Toshiki Moriyama Kunihiro Yamagata Narita Ichiei Masato Kasahara Yugo Shibagaki Masahide Kondo Koichi Asahi Tsuyoshi Watanabe Kazuhiko Tsuruya 《Geriatrics & Gerontology International》2023,23(4):282-288
284.
Shunsuke Furukawa Masatsugu Hiraki Michiaki Akashi Naoya Kimura Yukihiko Takahashi Ryuichiro Samejima 《Asian journal of endoscopic surgery》2023,16(4):761-765
A coexisting short-circuit from the inferior mesenteric vein (IMV) to the inferior vena cava, known as a Retzius shunt, and arteriovenous malformation (AVM) of the inferior mesentery are extremely rare conditions. We encountered a case of rectal cancer with coexisting Retzius shunt and inferior mesenteric AVM successfully treated with laparoscopic surgery. Contrast computed tomography (CT) in a 62-year-old man with rectal cancer showed multiple dilated veins at the mesenterium of the descending sigmoid colon. These dilated veins were connected between the IMV and the left renal vein. A diagnosis of Retzius shunt was made, and laparoscopic low anterior resection with lymph node dissection was performed. A pathological examination of the colonic mesenterium revealed AVM communicating with the dilated IMV and Retzius shunt. The preoperative evaluation of aberrant vessels by three-dimensional CT is particularly useful for patients with vascular malformations to ensure safe laparoscopic surgery. 相似文献