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排序方式: 共有477条查询结果,搜索用时 734 毫秒
191.
192.
降粘活血袋泡剂的制备及临床观察 总被引:2,自引:0,他引:2
目的:研制降粘活血袋泡剂,探讨降粘活血袋泡剂治疗高粘血症的疗效及不良反应。方法:制定降粘活血袋泡剂制备工艺、质量标准。观察患者243例,随机分为治疗组和对照组。治疗组158例,服降粘活血袋泡剂。对照组85例,服维脑路通片。一疗程3个月,复查血脂、血糖、肝肾功能。结果:制剂稳定。治疗组血浆比粘度、血浆纤维蛋白原均恢复到正常值水平,P〈0.01。对照组血浆比粘度、血浆纤维蛋白原亦有下降,P〈0.05。 相似文献
193.
Seventeen cases of an aberrant sheet of tissue in the amniotic cavity are described to expand and clarify previous observations of this entity. The sheet of tissue demonstrates a thickened base and a free edge that undulates. The fetus moves freely about the sheet of tissue. There are no associated fetal deformities, and infants have no manifestations of the amniotic-band syndrome. Evidence suggests that these sheets may originate from "wrapping" of the amniochorionic membrane over a uterine synechia. These benign sheets of tissue should not be confused with the amniotic-band syndrome. 相似文献
194.
Balasrinivasa R. Sajja Aditya N. Bade Biyun Zhou Mariano G. Uberti Santhi Gorantla Howard E. Gendelman Michael D. Boska Yutong Liu 《Journal of neuroimmune pharmacology》2016,11(1):133-141
Strain specific mouse brain magnetic resonance imaging (MRI) atlases provide coordinate space linked anatomical registration. This allows longitudinal quantitative analyses of neuroanatomical volumes and imaging metrics for assessing the role played by aging and disease to the central nervous system. As NOD/scid-IL-2Rγ c null (NSG) mice allow human cell transplantation to study human disease, these animals are used to assess brain morphology. Manganese enhanced MRI (MEMRI) improves contrasts amongst brain components and as such can greatly help identifying a broad number of structures on MRI. To this end, NSG adult mouse brains were imaged in vivo on a 7.0 Tesla MR scanner at an isotropic resolution of 100 μm. A population averaged brain of 19 mice was generated using an iterative alignment algorithm. MEMRI provided sufficient contrast permitting 41 brain structures to be manually labeled. Volumes of 7 humanized mice brain structures were measured by atlas-based segmentation and compared against non-humanized controls. The humanized NSG mice brain volumes were smaller than controls (p?<?0.001). Many brain structures of humanized mice were significantly smaller than controls. We posit that the irradiation and cell grafting involved in the creation of humanized mice were responsible for the morphological differences. Six NSG mice without MnCl2 administration were scanned with high resolution T2-weighted MRI and segmented to test broad utility of the atlas. 相似文献
195.
Swartz JD; Mandell DM; Faerber EN; Popky GL; Ardito JM; Steinberg SB; Rojer CL 《Radiology》1985,157(2):395-398
Ossification of the membranous labyrinth (labyrinthitis ossificans) develops as the final result of many inflammatory processes, for example, meningitis, blood-borne septic emboli, middle ear infection, and cholesteatoma. Labyrinthine ossification may also occur as a result of previous labyrinthectomy or secondary to trauma. Seven cases of labyrinthine ossification accompanied by severe vertigo and total hearing loss in the affected ear are discussed. The computed tomographic appearance of varying degrees of ossification, the clinical and surgical circumstances from which this disorder may develop, and the various approaches to labyrinthectomy are described. 相似文献
196.
Bifid origin of the left vertebral artery 总被引:1,自引:0,他引:1
Two patients demonstrating a bifid origin of the left vertebral artery are described. The embryologic origin of this anomaly is reviewed together with diagnostic and therapeutic implications, emphasizing the importance of knowledge and recognition of the anomaly. It is suggested that this anomaly is not as rare as previously thought. 相似文献
197.
198.
RT Chen JW Glasser PH Rhodes RL Davis WE Barlow RS Thompson JP Mullooly SB Black HR Shinefield CM Vadheim SM Marcy JI Ward RP Wise SG Wassilak SC Hadler 《Pediatrics》1997,99(6):765-773
OBJECTIVE: To fill the large "gaps and limitations" in current scientific knowledge of rare vaccine adverse events identified in recent reviews of the Institute of Medicine. METHODS: Computerized information on immunization, medical outcomes, and potential confounders on more than 500 000 children 0 to 6 years of age is linked annually at several health maintenance organizations to create a large cohort for multiple epidemiologic studies of vaccine safety. RESULTS: Analysis of 3 years of follow-up data shows that 549 488 doses of diphtheria-tetanus-pertussis (DTP) and 310 618 doses of measles-mumps-rubella (MMR) vaccines have been administered to children in the study cohort. Analyses for associations between vaccines and 34 medical outcomes are underway. Screening of automated data shows that seizures are associated with receipt of DTP on the same day (relative risk [RR], 2.1; 95% confidence interval [CI], 1.1 to 4.0) and 8 to 14 days after receipt of MMR (RR, 3.0; 95% CI, 2.1 to 4.2). The diversity of vaccination exposures in this large cohort permits us to show that an apparent association of seizures 8 to 14 days after Haemophilus influenzae type b vaccine (RR, 1.6; 95% CI, 1.2 to 2.1) was attributable to confounding by simultaneous MMR vaccination; the association disappears with appropriate adjustment (RR, 1.0; 95% CI, 0.7 to 1.4). CONCLUSION: Preliminary design, data collection, and analytic capability of the Vaccine Safety Datalink project has been validated by replication of previous known associations between seizures and DTP and MMR vaccines. The diversity in vaccine administration schedules permits potential disentangling of effects of simultaneous and combined vaccinations. The project provides a model of public health-managed care collaborations in addition to an excellent infrastructure for safety and other studies of vaccines. 相似文献
199.
Susan S Huang James M Livingston Nigel SB Rawson Steven Schmaltz Richard Platt 《BMC medical research methodology》2007,7(1):20
Background
Claims data provide rapid indicators of SSIs for coronary artery bypass surgery and have been shown to successfully rank hospitals by SSI rates. We now operationalize this method for use by payers without transfer of protected health information, or any insurer data, to external analytic centers. 相似文献200.
De novo mutations (GAG deletion) in the DYT1 gene in two non-Jewish patients with early-onset dystonia 总被引:3,自引:0,他引:3
Klein C; Brin MF; de Leon D; Limborska SA; Ivanova-Smolenskaya IA; Bressman SB; Friedman A; Markova ED; Risch NJ; Breakefield XO; Ozelius LJ 《Human molecular genetics》1998,7(7):1133-1136
The DYT1 gene recently has been cloned and shown to contain a three
nucleotide (GAG) deletion responsible for most cases of autosomal dominant
early-onset torsion dystonia. This deletion results in the loss of one of a
pair of glutamic acids in a conserved region of a novel ATP-binding protein
(torsinA). Previous haplotype analysis revealed that this same deletion had
arisen at least two different times in history, suggesting independent
mutational events. This deletion is the only sequence change found thus far
to be associated uniquely with the disease status, regardless of ethnic
origin. Here we describe two patients with typical early-onset torsion
dystonia of Swiss-Mennonite and non-Jewish Russian origin, respectively,
that both carry this same mutation as a de novo GAG deletion. This finding
proves that this 3 bp deletion in the DYT1 gene is indeed a mutation that
causes early-onset torsion dystonia. The DYT1 mutation is one of the rare
examples of the same recurrent mutation causing a dominantly inherited
condition. The sequence surrounding the GAG deletion contains an imperfect
24 bp tandem repeat, suggesting a possible mechanism for the high frequency
of this mutation.
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