全文获取类型
收费全文 | 423篇 |
免费 | 31篇 |
国内免费 | 23篇 |
专业分类
儿科学 | 18篇 |
妇产科学 | 6篇 |
基础医学 | 45篇 |
口腔科学 | 9篇 |
临床医学 | 39篇 |
内科学 | 110篇 |
皮肤病学 | 31篇 |
神经病学 | 14篇 |
特种医学 | 77篇 |
外科学 | 46篇 |
综合类 | 18篇 |
预防医学 | 4篇 |
眼科学 | 3篇 |
药学 | 38篇 |
肿瘤学 | 19篇 |
出版年
2023年 | 5篇 |
2022年 | 1篇 |
2021年 | 5篇 |
2019年 | 8篇 |
2018年 | 7篇 |
2017年 | 6篇 |
2016年 | 4篇 |
2015年 | 11篇 |
2014年 | 7篇 |
2013年 | 15篇 |
2012年 | 9篇 |
2011年 | 11篇 |
2010年 | 16篇 |
2009年 | 21篇 |
2008年 | 19篇 |
2007年 | 24篇 |
2006年 | 19篇 |
2005年 | 17篇 |
2004年 | 16篇 |
2003年 | 13篇 |
2002年 | 12篇 |
2001年 | 9篇 |
2000年 | 3篇 |
1999年 | 7篇 |
1998年 | 21篇 |
1997年 | 15篇 |
1996年 | 28篇 |
1995年 | 8篇 |
1994年 | 18篇 |
1993年 | 8篇 |
1992年 | 4篇 |
1991年 | 6篇 |
1990年 | 10篇 |
1989年 | 7篇 |
1988年 | 14篇 |
1987年 | 10篇 |
1986年 | 8篇 |
1985年 | 11篇 |
1984年 | 5篇 |
1983年 | 5篇 |
1982年 | 6篇 |
1981年 | 6篇 |
1980年 | 5篇 |
1979年 | 1篇 |
1978年 | 3篇 |
1977年 | 4篇 |
1976年 | 6篇 |
1975年 | 3篇 |
排序方式: 共有477条查询结果,搜索用时 0 毫秒
161.
Xiaopeng Zhang Yaming Chen Larry W Jenkins Patrick M Kochanek Robert SB Clark 《Critical care (London, England)》2004,9(1):1-10
Despite continuous advances in technologic and pharmacologic management, the mortality rate from septic shock remains high. Care of patients with sepsis includes measures to support the circulatory system and treat the underlying infection. There is a substantial body of knowledge indicating that fluid resuscitation, vasopressors, and antibiotics accomplish these goals. Recent clinical trials have provided new information on the addition of individual adjuvant therapies. Consensus on how current therapies should be prescribed is lacking. We present the reasoning and preferences of a group of intensivists who met to discuss the management of an actual case. The focus is on management, with emphasis on the criteria by which treatment decisions are made. It is clear from the discussion that there are areas where there is agreement and areas where opinions diverge. This presentation is intended to show how experienced intensivists apply clinical science to their practice of critical care medicine. 相似文献
162.
DDAVP in type IIa von Willebrand's disease 总被引:1,自引:0,他引:1
Gralnick HR; Williams SB; McKeown LP; Rick ME; Maisonneuve P; Jenneau C; Sultan Y 《Blood》1986,67(2):465-468
1-D-Amino(8-D-arginine)-vasopressin (DDAVP) infusion in three patients with type IIa von Willebrand's disease (vWD) resulted in a normalization of the factor VIII coagulant, factor VIII-related antigen, and von Willebrand factor (vWF) (ristocetin cofactor) activities and the bleeding time. The normalization of these hemostatic parameters persisted for four hours. Over the same time period there was a marked increase in the quantity of the vWF multimers when blood was collected in the presence of protease inhibitors. The vWF multimers present were even larger than the normal. When blood was collected in the absence of protease inhibitors, a smaller increase in the plasma vWF multimers was observed and fewer of the intermediate and larger vWF multimers were seen; multimers larger than those present in normal plasma were not visualized. The platelet vWF multimers and activities did not change with or without inhibitors. These studies suggest that there is a subgroup of patients with type IIa vWD who respond to DDAVP with complete normalization of their hemostatic abnormalities and whose vWF is sensitive to proteolysis. 相似文献
163.
Two well-circumscribed keratotic plaques in an elderly man, one each on symmetrically. identical over the sides of the buttocks, are described. Clinical and histopathological features supported the diagnosis of benign lichenoid keratosis, which had probably resulted from constant pressure over the site and regressed when this factor was eliminated. 相似文献
164.
165.
利用Dot blot 和流式细胞术,研究了分化诱导剂维甲酸,DMSO对HL-60细胞及其抗性亚型抗药性程度的影响,表明1μmol·ml-1 RA 作用H-60及其亚型24h, MDR 1 mRNA 明显增高,但流式检测多药抗性细胞系对Rho-123的外排有所下降。2%DMSO作用HL-60及其亚型 24h,流式细胞术检测显示各细胞系对Rho-123 的外排明显增强,提示RA 虽然提高MDR 1基因的表达,但可能通过磷酸化/脱磷酸化方式抑制Pgp-170功能的表达,而DMSO能诱导完整功能的Pgp表达。 相似文献
166.
DG Fullerton SB Gordon 《Malawi medical journal : the journal of Medical Association of Malawi》2003,15(2):68-71
Domestic smoke exposure and early HIV infection are critical but unseen risk factors for pneumonia. This paper reviews how recent research in Malawi and elsewhere contributes to an understanding of the possible immunological mechanisms underlying these risks. 相似文献
167.
High-resolution (10-MHz) ultrasonography was performed in 181 patients with primary or secondary hyperparathyroidism during a 4-year period and evaluated retrospectively. Thirty-seven unusual-appearing parathyroid tumors were found among 235 parathyroid glands identified as abnormal. There was pathologic correlation in 36. The typical appearance of parathyroid adenoma was that of an oval hypoechoic or anechoic lesion in the neck, aligned in a craniocaudal direction and often posterior to the thyroid. Morphologic variations from the norm included giant size (n = 11) (4.6%), cystic changes in a solid tumor (n = 9) (3.8%), calcified glands (n = 6[in three patients]) (2.5%), a multilobulated configuration (n = 5) (2.1%), an inhomogeneous pattern (n = 5) (2.1%), and a parathyroid cyst (n = 1) (0.4%). Recognizing the abnormal parathyroid variants can increase the diagnostic accuracy of sonographic examination. 相似文献
168.
Ultrasound in acute renal transplant rejection 总被引:1,自引:0,他引:1
169.
Brown SB; Hedlund GL; Glasier CM; Williams KD; Greenwood LH; Gilliland JD 《Radiology》1987,164(2):475-478
Four infants with congenital or acquired tracheobronchial stenosis were successfully treated with angioplasty balloon catheter dilation. The technical details and complications of these procedures are described. The authors believe balloon dilation therapy should be considered as the initial form of therapy for tracheal stenosis in infants, even in the presence of complex stenotic lesions. 相似文献
170.