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排序方式: 共有465条查询结果,搜索用时 15 毫秒
81.
Max J. Coppes Ron A. Anderson Lillian Rallison Ross Truscott 《Pediatric hematology and oncology》2013,30(6):501-507
This study examined the salient clinical and epidemiological characteristics of retinoblastoma (RB) in India, thereby highlighting the problems encountered there. The epidemiological characteristics of 296 patients with RB over 8 years were evaluated using hospital records and postal follow-ups. Unilateral disease was seen in 61.8% of patients. The overall median age at presentation was 3.5 years (3.5 years for unilateral RB and 1.0 years for bilateral RB). The male/female ratio was 1.4:1. The median duration of symptomatic disease was 8 months. Consanguineous marriage was seen in 17% and family history of RB was noted in 1.7% cases. Also, 2 % had a history of other malignancy in the family. Associated congenital malformation was seen in 10.5% of cases. A second malignancy was seen in 0.67% of cases at a mean duration of 4.5 years after completion of therapy. A predominance of advanced-stage disease (74.5% had Reese-Ellsworth group TV and V disease) was seen in our series. Only 43.6% of patients had disease localized to the globe without any infiltration/invasion. The majority of cases had advanced-stage disease at presentation and came from the underprivileged class of society. Patients with bilateral RB presented much earlier than those with unilateral disease. In patients with unilateral RB, higher age at presentation as well as advanced disease may be related to much delay in seeking medical attention. In view of the advanced stage at presentation, there also exist a possibility of difference in the biology of the tumor seen in these patients. 相似文献
82.
Timothy Shiraev Sundeep Singh Pasricha Peter Choong Stephen Schlicht Catharina SP van Rijswijk Simon Dimmick Stephen Stuckey Suzanne E Anderson 《Journal of Medical Imaging and Radiation Oncology》2013,57(6):687-700
Retroperitoneal sarcomas are a rare disease. The overall 5‐year survival rate for these lesions remains low, and surgical management offers the only option for effective treatment and potential for cure. Radiotherapy is increasingly being employed in addition to standard surgical treatment. Improvements in cross‐sectional imaging have also facilitated better characterisation of lesions, preoperative planning and long‐term follow‐up. This article reviews the current literature and documents the various types of retroperitoneal sarcomas with a particular approach to their imaging features. We also highlight the pathology, diagnostic methods and most current management of these tumours. 相似文献
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84.
Joining the dots: a plea for precise estimates of the maternal mortality ratio in sub-Saharan Africa
Monitoring of maternal mortality levels in sub-Saharan Africa (SSA) to assess the achievements of safe motherhood programmes and for MDG-5 has been made difficult because of the lack of precise estimates of the maternal mortality ratio (MMR). Projections based on the slow rate of decline of the MMR indicate that MDG-5 may not be reached before the end of this century in this region. Measurements done using demographical and health surveys, statistical modelling and censuses are imprecise and do not allow trends in individual countries to be established. SSA countries should be encouraged to measure mortality levels from their own resources, using methods that produce precise estimates such as population-based surveys. Establishment of the trends will lead to country-specific program targets. The less frequent but more precise measurements can be afforded by SSA countries, as a case study from Zimbabwe shows. 相似文献
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88.
合欢皮中三萜皂甙元的研究 总被引:3,自引:0,他引:3
合欢皮中三萜皂甙元的研究陈四平张如意(北京医科大学植化教研室,北京100083)中药合欢皮(Albizziaecortex)为合欢(AlbizziaejulibrisinDurazz)树皮。具解郁安神,活血消肿功能。用于心神不安,忧郁失眠,肺痈疮肿... 相似文献
89.
NM Gude RG King SP Brennecke 《Clinical and experimental pharmacology & physiology》1998,25(9):706-711
1. Interactions between autacoids may play important roles in the regulation of blood flow in the foetal placenta. In order to investigate this aspect of placental haemodynamics, human normal-term placentae were perfused in vitro and the responses of the foetal vessels to various combinations of vasoactive agents were determined. 2. Vasoconstriction responses to 5-hydroxytryptamine (5-HT) were potentiated in the presence of endothelin-1 (ET-1), the thromboxane A2-mimetic U46619 and a nitric oxide synthase inhibitor, N-nitro-l -arginine (NOLA), but not in the presence of angiotensin II. 3. N-Nitro-l -arginine caused vasoconstriction of the perfused placenta and indomethacin attenuated this effect and blocked the potentiation of the 5-HT response by NOLA. 4. Indomethacin did not affect ET-1-induced pressure increases and infusion of U46619 had no effect on release of ET-Iike immunoreactivity into the foetal placental circulation. 5. The present study provides evidence of interactions between several autacoids in human perfused placentae in vitro. These interactions may play important roles in foetal placental haemodynamics in normal or pathological situations. 相似文献
90.
SP Taylor 《Clinical & experimental optometry》1989,72(6):181-185
Wavelength discrimination was studied on three colour-normal human observers for open viewing and for reduced time viewing. All three observers show a loss of blue-green wavelength discrimination when viewing time is reduced to 3.75 msec. This loss is shown to be an effect of viewing time alone and not of reduced retinal illuminance. The results confirm those reported by Foster, Scase and Taylor1 although the target size and methodology are different. 相似文献