NONBLADDER RELATED SYMPTOMS IN PATIENTS WITH INTERSTITIAL CYSTITIS

PURPOSE: Clinical experience and epidemiological studies suggest that patients with interstitial cystitis have multiple nonbladder related symptoms. However, to our knowledge this finding has not been tested with a validated questionnaire and matched controls. With the University of Wisconsin scale, we compare the scores for patients with interstitial cystitis to those for control subjects. This validated questionnaire includes 7 bladder and 18 reference symptoms not related to the bladder. MATERIALS AND METHODS: A total of 35 female patients with interstitial cystitis and 35 age matched female controls completed the University of Wisconsin questionnaire. RESULTS: For the 7 bladder symptoms the difference between interstitial cystitis and control groups was extremely significant (p = 0.0001). Patients with interstitial cystitis had higher scores than controls for 2 reference symptoms, including other pelvic discomfort, backache, dizziness, chest pain, aches in joints, abdominal cramps, nausea, heart pounding and headache (p <0.01). However, they did not have higher scores for blind spots and/or blurred vision, numbness and/or tingling in fingers or toes, swollen ankles, feeling of suffocation, sore throat, cough, flu, nasal congestion and ringing in ears. The majority of patients with interstitial cystitis had a 0 score for all but 2 of the reference symptoms. CONCLUSIONS: Patients with interstitial cystitis had increased scores for 9 reference symptoms but did not indiscriminately report high scores for generalized complaints. This result suggests that in some cases of interstitial cystitis the pathophysiology may affect other organ systems besides the bladder. Alternatively, some of these symptoms may result from changes in sleep pattern or other factors associated with interstitial cystitis.     

Dynamic Beat-to-Beat QT-RR Relationship During Physiotherapy Effort in Elderly Patients Without Primary Heart Disease

The ECGs from 18 patients hospitalized in a rehabilitation setting, following surgery for hip fracture, were examined to characterize the dynamic behavior of uncorrected QT interval in relation to changing RR interval during physiotherapy effort. ECG waveforms were analyzed to extract beat-to-beat QT and RR intervals using a computerized ECG Analyzer (CEA-1100). The method of defining the QT and RR intervals is based on performing multiple cross-correlations that enable rejection of artifacts from the analysis. The relationship between the RR and QT intervals was found using the following general formula QTi = cRRi-1b. Linear regression was performed on the logarithms of QT and RR measurements obtained to estimate the constant (a = log c) and the slope (b) values, reflecting the dynamic change of QT during physiotherapy effort. Having these two values, the dynamic QT extrapolated to a heart period of 1 second (QTcd) was calculated. The results were compared to the conventional corrected static QT according to the Bazzet formula (QTcs). The mean values of constants (a = log c) and slopes (b) over all patients were found to be 1.61 +/- 0.23 and 0.33 +/- 0.08, respectively, giving a QT (ms) heart-period (ms) dynamic relation of QTi = 41 x RR(i-1)0.33. The correlation between the dynamic QT and the static QT intervals was not significant. The mean values of the QTcd and QTcs intervals were significantly different (392 +/- 25 ms vs 434 +/- 28 ms; P < 0.0001). This dynamic measurement method of QT intervals may provide additional information on normal and abnormal cardiac repolarization in health and disease, helping in the diagnosis of cardiac disorders and arrhythmia risk.     

Three‐Dimensional Vessel Analyses Provide More Accurate Length Estimations than the Gold Standard QCA

Objectives: The aim of this study was to compare lesion dimensions as determined by a three‐dimensional quantitative coronary angiographic (QCA) system to that of a validated two‐dimensional QCA system. Background: In an era of drug‐eluting stents, device sizing has become an important clinical application of online QCA. The CardiOp‐B system integrates two standard angiographic projections to provide a three‐dimensional reconstruction of the arterial segment of interest. Methods: Phase 1 — 47 stenoses from consecutive coronary angiograms were assessed in two projections with both systems providing two data sets for the CMS‐Medis system and a single data set for CardiOp‐B. Phase 2 — a perspex phantom with a known lesion length, was analyzed at increasing degrees of foreshortening with acceptance criteria set at 5% from the absolute value. Results: Phase 1 demonstrated an adequate correlation between the CardiOp‐B and Medis systems when minimal luminal diameter was measured in the optimal view (1.32 ± 0.47 mm vs 1.42 ± 0.49 mm respectively; r = 0.82). A stronger correlation was noted when length was measured (25.27 ± 10.76 mm and 21.32 ± 8.08 mm, respectively; r = 0.95); however CardiOp‐B provided a consistently longer length (P < 0.0001). On phantom length measurements the mean accuracy result for the CardiOp‐B system was ?1.3%. This compared favorably with the two‐dimensional system where all measures performed at greater than 20 degrees of forshortening were beyond the 5% criteria from the known length. Conclusions: Three‐dimensional QCA provides accurate and precise vessel diameter assessments. Length assessments are consistently longer than two‐dimensional measures and are significantly less affected by foreshortened projections. (J Interven Cardiol 2010;23:152‐159)     

A comparison of the STORZ video laryngoscope and standard direct laryngoscopy for intubation in the Pediatric airway – a randomized clinical trial

Introduction:  Direct laryngoscopy can be challenging in infants and neonates. Even with an optimal line of sight to the glottic opening, the viewing angle has been measured at 15°. The STORZ DCI video laryngoscope (Karl Storz, Tuttlingen, Germany) incorporates a fiberoptic camera in the light source of a standard laryngoscope of variable sizes. The image is displayed on a screen with a viewing angle of 80°. We studied the effectiveness of the STORZ DCI as an airway tool compared to standard direct laryngoscopy in children with normal airway.
Methods:  In this prospective, randomized study, 56 children (ages 4 years or younger) undergoing elective surgery with the need for endotracheal intubation were divided into two groups: children who underwent standard direct laryngoscopy using a Miller 1 or Macintosh 2 blade (DL) and children who underwent video laryngoscopy using the STORZ DCI video laryngoscope with a Miller 1 blade (VL). Time to best view (TTBV), time to intubate (TTI), Cormack–Lehane (CL), and percentage of glottis opening seen (POGO) score were recorded.
Results:  TTBV in DL was 5.5 (4–8) s and 7 (4.2–9) s in VL. TTI in DL was 21 (17–29) s and in VL 27 (22–37) s ( P  = 0.006). The view as assessed by POGO score was 97.5% (60–100%) in DL and 100% (100–100%) in the VL ( P  = 0.003). Data are presented as median and interquartile range and analyzed using t -test.
Discussion:  This study demonstrates that the STORZ DCI video laryngoscope provides an improved view to the glottis in children with normal airway anatomy, but requires a longer time for intubation.     

THE USE OF THE APPENDIX AS A CONTINENT CATHETERIZABLE STOMA

Purpose

We review the results of 5 years of using the unmodified appendix for reconstruction of neobladders and native bladders, and describe the mechanism of continence.

Materials and Methods

Between 1993 and 1997, 24 patients have undergone continent urinary diversion using the unaltered appendix. Median patient age at the time of surgery was 62 years. Patients were followed at the urological outpatient clinic for a mean of 18 months (range 7 to 47). Video urodynamic studies were performed once in the first 6 months postoperatively and repeated if there was any history of incontinence or bladder problems.

Results

Of the patients with an appendicovesicostomy onto the native bladder 80% were dry during the day and night. This figure was improved to 94% when 2 patients with incontinence catheterized more frequently. Patients with a neobladder were more likely to be continent and had a longer interval between catheterizations, which reflects the larger reservoir volume rather than better continence mechanism in these patients. The level of continence is at the appendiceal bladder junction in the native bladder and the appendicocecal junction in the neobladder, which is able to withstand reservoir pressures of 30 to 40 cm. water. Stress incontinence driven by abdominal pressure did not occur. Instead incontinence occurred when the bladder became over full and the pressure increased, or during an unstable contraction.

Conclusions

The appendix does not need to be tunneled through the bladder wall to achieve satisfactory continence. In a low pressure reservoir continence may be achieved simply by anastomosing the appendix directly onto the bladder or leaving it in situ when creating a neobladder.